Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest

Out-of-hospital cardiac arrest (OHCA) is heterogeneous in terms of etiology and severity. Owing to this heterogeneity, differences in outcome and treatment efficacy have been reported from case to case; however, few reviews have focused on the heterogeneity of OHCA. We conducted a literature review to identify differences in the prognosis and treatment efficacy in terms of CA-related waveforms (shockable or non-shockable), age (adult or pediatric), and post-CA syndrome severity and to determine the preferred treatment for patients with OHCA to improve outcomes.

[1]  M. Kassabry The effect of simulation-based advanced cardiac life support training on nursing students’ self-efficacy, attitudes, and anxiety in Palestine: a quasi-experimental study , 2023, BMC Nursing.

[2]  W. Kim,et al.  Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry) , 2023, Critical Care.

[3]  J. Tijssen,et al.  Epidemiology of paediatric out-of-hospital cardiac arrest in Ontario, Canada , 2023, Resuscitation Plus.

[4]  P. Chan,et al.  Comparison of Out‐of‐Hospital Cardiac Arrest Outcomes Between Asian and White Individuals in the United States , 2023, Journal of the American Heart Association.

[5]  D. Stub,et al.  Epidemiology of pediatric out-of-hospital cardiac arrest compared with adults. , 2023, Heart rhythm.

[6]  K. Reinier,et al.  Temporal Trends in Incidence and Survival from Sudden Cardiac Arrest Manifesting with Shockable and Nonshockable Rhythms: A 16-Year Prospective Study in a Large US Community. , 2023, Annals of Emergency Medicine.

[7]  H. Yasuda,et al.  Advanced airway management for pediatric out-of-hospital cardiac arrest: A systematic review and network meta-analysis. , 2023, The American journal of emergency medicine.

[8]  C. Callaway Targeted temperature management with hypothermia for comatose patients after cardiac arrest , 2023, Clinical and experimental emergency medicine.

[9]  J. Soar,et al.  Epinephrine in Out-of-Hospital Cardiac Arrest - A Network Meta-Analysis and Subgroup Analyses of Shockable and Non-Shockable Rhythms. , 2023, Chest.

[10]  C. Torp-Pedersen,et al.  Pediatric out-of-hospital cardiac arrest in Denmark , 2022, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.

[11]  C. Hassager,et al.  Duration of Device-Based Fever Prevention after Cardiac Arrest. , 2022, The New England journal of medicine.

[12]  J. Gräsner,et al.  Development of the epidemiology and outcomes of out-of-hospital cardiac arrest using data from the German Resuscitation Register over a 15-year period (EpiCPR study). , 2022, Resuscitation.

[13]  S. Hwang,et al.  National Surveillance of Pediatric Out-of-Hospital Cardiac Arrest in Korea: The 10-Year Trend From 2009 to 2018 , 2022, Journal of Korean medical science.

[14]  É. Marijon,et al.  Differential Effect of Targeted Temperature Management Between 32°C and 36°C Following Cardiac Arrest According to Initial Severity of Illness: Insights From Two International Data Sets. , 2022, Chest.

[15]  M. Huptych,et al.  Initial rhythm and survival in refractory out-of-hospital cardiac arrest. Post-hoc analysis of the Prague OHCA randomized trial. , 2022, Resuscitation.

[16]  N. Shime,et al.  Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out‐of‐Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry , 2022, Journal of the American Heart Association.

[17]  I. Kukita,et al.  Survival From Pediatric Out-of-Hospital Cardiac Arrest During Nights and Weekends , 2022, JACC. Asia.

[18]  B. Ruijter,et al.  Effects of targeted temperature management at 33°C vs. 36°C on comatose patients after cardiac arrest stratified by the severity of encephalopathy. , 2022, Resuscitation.

[19]  J. Finn,et al.  The epidemiology of out-of-hospital cardiac arrest in Australia and New Zealand: A binational report from the Australasian Resuscitation Outcomes Consortium (Aus-ROC). , 2022, Resuscitation.

[20]  C. Callaway,et al.  Timing of Prehospital Advanced Airway Management for Adult Patients With Out‐of‐Hospital Cardiac Arrest: A Nationwide Cohort Study in Japan , 2021, Journal of the American Heart Association.

[21]  C. Callaway,et al.  Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest , 2021, New England Journal of Medicine.

[22]  N. Matsuda,et al.  Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry , 2021, Critical care medicine.

[23]  G. Perkins,et al.  European Resuscitation Council Guidelines 2021: Epidemiology of cardiac arrest in Europe. , 2021, Resuscitation.

[24]  M. Hazinski,et al.  Pediatric timing of epinephrine doses: A systematic review. , 2021, Resuscitation.

[25]  C. Callaway,et al.  Association of Initial Illness Severity and Outcomes After Cardiac Arrest With Targeted Temperature Management at 36 °C or 33 °C , 2020, JAMA network open.

[26]  B. McNally,et al.  Out-of-hospital Cardiac Arrest across the World: First Report from the International Liaison Committee on Resuscitation (ILCOR). , 2020, Resuscitation.

[27]  Y. Gan,et al.  The global survival rate among adult out-of-hospital cardiac arrest patients who received cardiopulmonary resuscitation: a systematic review and meta-analysis , 2020, Critical Care.

[28]  B. Giraudeau,et al.  Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. , 2019, The New England journal of medicine.

[29]  G. Perkins,et al.  The effects of adrenaline in out of hospital cardiac arrest with shockable and non-shockable rhythms: Findings from the PACA and PARAMEDIC-2 randomised controlled trials. , 2019, Resuscitation.

[30]  L. Wik,et al.  The effect of intravenous adrenaline on electrocardiographic changes during resuscitation in patients with initial pulseless electrical activity in out of hospital cardiac arrest. , 2019, Resuscitation.

[31]  C. Callaway,et al.  Pre-hospital advanced airway management for adults with out-of-hospital cardiac arrest: nationwide cohort study , 2019, BMJ.

[32]  J. Stamler,et al.  Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase , 2019, Circulation.

[33]  T. Aufderheide,et al.  Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial , 2018, JAMA.

[34]  C. Callaway,et al.  Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology , 2018, Critical care medicine.

[35]  G. Perkins,et al.  Regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest in Australia and New Zealand: Results from the Aus-ROC Epistry. , 2018, Resuscitation.

[36]  M. Ong,et al.  Epidemiology and outcome of paediatric out-of-hospital cardiac arrests: A paediatric sub-study of the Pan-Asian resuscitation outcomes study (PAROS). , 2018, Resuscitation.

[37]  Francesca N. Delling,et al.  Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association , 2018, Circulation.

[38]  G. Finco,et al.  Metabolomics profiling reveals different patterns in an animal model of asphyxial and dysrhythmic cardiac arrest , 2017, Scientific Reports.

[39]  Magdalena Roszak,et al.  Evaluation of virtual environment as a form of interactive resuscitation exam , 2017, New Rev. Hypermedia Multim..

[40]  Y. Goto,et al.  Duration of Prehospital Cardiopulmonary Resuscitation and Favorable Neurological Outcomes for Pediatric Out-of-Hospital Cardiac Arrests: A Nationwide, Population-Based Cohort Study , 2016, Circulation.

[41]  C. Callaway,et al.  Unchanged pediatric out-of-hospital cardiac arrest incidence and survival rates with regional variation in North America. , 2016, Resuscitation.

[42]  E. d’Aloja,et al.  The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management. , 2015, The American journal of emergency medicine.

[43]  L. Køber,et al.  Out-of-hospital cardiac arrests in children and adolescents: incidences, outcomes, and household socioeconomic status. , 2015, Resuscitation.

[44]  P. Kochanek,et al.  Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI. , 2014, Resuscitation.

[45]  Yi Zhang,et al.  Differences of postresuscitation myocardial dysfunction in ventricular fibrillation versus asphyxiation. , 2013, The American journal of emergency medicine.

[46]  M. Krizmaric,et al.  The dynamic pattern of end-tidal carbon dioxide during cardiopulmonary resuscitation: difference between asphyxial cardiac arrest and ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest , 2011, Critical care.

[47]  R. Berg,et al.  Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies. , 2010, Resuscitation.

[48]  R. Berg,et al.  Conventional and chest-compression-only cardiopulmonary resuscitation by bystanders for children who have out-of-hospital cardiac arrests: a prospective, nationwide, population-based cohort study , 2010, The Lancet.

[49]  D. Beiser,et al.  Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I , 2009, Circulation.

[50]  R. Berg,et al.  Epidemiology and Outcomes From Out-of-Hospital Cardiac Arrest in Children: The Resuscitation Outcomes Consortium Epistry–Cardiac Arrest , 2009, Circulation.

[51]  P. Safar,et al.  Asphyxiation versus ventricular fibrillation cardiac arrest in dogs. Differences in cerebral resuscitation effects--a preliminary study. , 1997, Resuscitation.

[52]  Paweł Szymczuk Mortality in OHCA during resuscitation by rescue teams without a doctor , 2019 .

[53]  Li-li Zhou,et al.  The differences in brain damage between asphyxial and ventricular fibrillation cardiac arrests , 2013 .