Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials

[1]  M. Levin,et al.  Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis. , 2003, The Journal of infectious diseases.

[2]  David Sutton,et al.  Herpes Simplex Virus Resistance to Acyclovir and Penciclovir after Two Decades of Antiviral Therapy , 2003, Clinical Microbiology Reviews.

[3]  R. Sarisky,et al.  Penciclovir Susceptibilities of Herpes Simplex Virus Isolates from Patients Using Penciclovir Cream for Treatment of Recurrent Herpes Labialis , 2002, Antimicrobial Agents and Chemotherapy.

[4]  R. Boon,et al.  Surveillance for Antiviral-Agent-Resistant Herpes Simplex Virus in the General Population with Recurrent Herpes Labialis , 2002, Antimicrobial Agents and Chemotherapy.

[5]  R. Sarisky,et al.  Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir , 2001, Journal of Virology.

[6]  P. Crosson,et al.  Antiviral susceptibilities of herpes simplex virus from immunocompetent subjects with recurrent herpes labialie: a UK-based survey. , 2000, The Journal of antimicrobial chemotherapy.

[7]  R. Sarisky,et al.  Difference in Incidence of Spontaneous Mutations between Herpes Simplex Virus Types 1 and 2 , 2000, Antimicrobial Agents and Chemotherapy.

[8]  Boon,et al.  Antiviral susceptibilities of herpes simplex virus from immunocompetent subjects with recurrent herpes labialis: a UK-based survey. , 2000, The Journal of antimicrobial chemotherapy.

[9]  D. Coen,et al.  Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis? , 1998, The Journal of infectious diseases.

[10]  H. Balfour,et al.  Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. , 1998, The Journal of infectious diseases.

[11]  G. Darby,et al.  Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England , 1998, Antimicrobial Agents and Chemotherapy.

[12]  D. Coen,et al.  Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants. , 1998, Antiviral research.

[13]  K. Schubert,et al.  Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir , 1997, Journal of virology.

[14]  D. Coen,et al.  Penciclovir-Resistance Mutations in the Herpes Simplex Virus DNA Polymerase Gene , 1995 .

[15]  H. Kessler,et al.  Herpes simplex virus resistance to acyclovir: clinical relevance. , 1995, Infectious agents and disease.

[16]  C. Crumpacker,et al.  Recurrence and Resistance Patterns of Herpes Simplex Virus following Cessation of ⩾6 Years of Chronic Suppression with Acyclovir , 1994 .

[17]  S. Safrin,et al.  In vitro activity of penciclovir against clinical isolates of acyclovir-resistant and foscarnet-resistant herpes simplex virus , 1993, Antimicrobial Agents and Chemotherapy.

[18]  P. Collins,et al.  Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir , 1993, Journal of medical virology.

[19]  H. Balfour,et al.  Herpes Simplex Virus Resistant to Acyclovir: A Study in a Tertiary Care Center , 1990 .

[20]  C. Crumpacker,et al.  Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. , 1989, The New England journal of medicine.

[21]  E. Swierkosz,et al.  Improved DNA hybridization method for detection of acyclovir-resistant herpes simplex virus , 1987, Antimicrobial Agents and Chemotherapy.

[22]  D. Sutton,et al.  Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture , 1987, Antimicrobial Agents and Chemotherapy.

[23]  D. Coen.  General aspects of virus drug resistance with special reference to herpes simplex virus. , 1986, The Journal of antimicrobial chemotherapy.

[24]  N. Flournoy,et al.  Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. , 1984, Annals of internal medicine.

[25]  B. Larder,et al.  Virus drug-resistance: mechanisms and consequences. , 1984, Antiviral research.

[26]  J. Hall,et al.  Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. , 1984, Virology.

[27]  J. Meyers,et al.  Frequency and significance of acyclovir-resistant herpes simplex virus isolated from marrow transplant patients receiving multiple courses of treatment with acyclovir. , 1983, The Journal of infectious diseases.

[28]  N. Flournoy,et al.  Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation: a double-blind trial. , 1982, Annals of internal medicine.

[29]  C. Crumpacker,et al.  Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir. , 1982, The New England journal of medicine.

[30]  C. Cunningham-Rundles,et al.  Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. , 1981, The New England journal of medicine.

[31]  P. Schaffer,et al.  Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[32]  C. Crumpacker,et al.  Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[33]  H. Schaeffer,et al.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. , 1977, Proceedings of the National Academy of Sciences of the United States of America.