The role of PDGF-B/PDGFR-BETA axis in the normal development and carcinogenesis of the breast.

[1]  R. Simmons,et al.  The impact of molecular subtype on breast cancer recurrence in young women treated with contemporary adjuvant therapy , 2018, The breast journal.

[2]  G. Manic,et al.  Deciphering the loop of epithelial-mesenchymal transition, inflammatory cytokines and cancer immunoediting. , 2017, Cytokine & growth factor reviews.

[3]  L. Mi,et al.  Expression and purification of functional PDGF receptor beta. , 2017, Biochemical and biophysical research communications.

[4]  Dawei Xu,et al.  Platelet releasate promotes breast cancer growth and angiogenesis via VEGF–integrin cooperative signalling , 2017, British Journal of Cancer.

[5]  J. Dutil,et al.  Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair , 2017, International journal of molecular sciences.

[6]  F. Portillo,et al.  EMT: Present and future in clinical oncology , 2017, Molecular oncology.

[7]  P. Lacal,et al.  Platelet-derived growth factor-C promotes human melanoma aggressiveness through activation of neuropilin-1 , 2017, Oncotarget.

[8]  J. Fuxe,et al.  Epithelial‐mesenchymal transition in cancer metastasis through the lymphatic system , 2017, Molecular oncology.

[9]  C. Perou,et al.  Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer , 2017, Science Translational Medicine.

[10]  D. Ribatti,et al.  Triple negative breast cancer: the kiss of death , 2017, Oncotarget.

[11]  C. Betsholtz,et al.  Expression analysis of platelet‐derived growth factor receptor alpha and its ligands in the developing mouse lung , 2017, Physiological reports.

[12]  H. Akbari Javar,et al.  Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes , 2017, Drug design, development and therapy.

[13]  O. Bălăcescu,et al.  The Role of PDGFs and PDGFRs in Colorectal Cancer , 2017, Mediators of inflammation.

[14]  G. Pond,et al.  Claudin-Low Breast Cancer; Clinical & Pathological Characteristics , 2017, PloS one.

[15]  Sanghui Park,et al.  Strong Correlation of Indoleamine 2,3-Dioxygenase 1 Expression with Basal-Like Phenotype and Increased Lymphocytic Infiltration in Triple-Negative Breast Cancer , 2017, Journal of Cancer.

[16]  M. Katoh.  Therapeutics Targeting FGF Signaling Network in Human Diseases. , 2016, Trends in pharmacological sciences.

[17]  I. Alafuzoff,et al.  Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells , 2016, Oncotarget.

[18]  C. Betsholtz,et al.  Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart , 2016, PloS one.

[19]  C. Park,et al.  Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma , 2016, Breast Cancer Research and Treatment.

[20]  Liqun He,et al.  A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex , 2016, Biology Open.

[21]  K. Pietras,et al.  Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD , 2016, Proceedings of the National Academy of Sciences.

[22]  Chin‐Chung Wu,et al.  Inhibition of the interactions between metastatic human breast cancer cells and platelets by β-nitrostyrene derivatives. , 2015, Life sciences.

[23]  Sriganesh Srihari,et al.  Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease. , 2015, Trends in pharmacological sciences.

[24]  A. Bahnassy,et al.  Molecular biomarkers for prediction of response to treatment and survival in triple negative breast cancer patients from Egypt. , 2015, Experimental and molecular pathology.

[25]  Ö. Türeci,et al.  CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer , 2015, Oncotarget.

[26]  Choung-Soo Kim,et al.  Prognostic significance of platelet-derived growth factor receptor-β expression in localized clear cell renal cell carcinoma , 2015, Journal of Cancer Research and Clinical Oncology.

[27]  P. Tan,et al.  Role of epithelial–mesenchymal transition markers in triple-negative breast cancer , 2015, Breast Cancer Research and Treatment.

[28]  A. Gaikwad,et al.  Curcumin as an adjuvant to breast cancer treatment. , 2015, Anti-cancer agents in medicinal chemistry.

[29]  J. Sparano,et al.  Therapies for triple negative breast cancer , 2015, Expert opinion on pharmacotherapy.

[30]  XiaoNa Wei,et al.  Effect of platelet-derived growth factor-B on renal cell carcinoma growth and progression. , 2015, Urologic oncology.

[31]  M. Raica,et al.  Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges , 2015, Archives of medical science : AMS.

[32]  Chen Huang,et al.  FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway , 2015, Oncotarget.

[33]  Won-Serk Kim,et al.  The pivotal role of PDGF and its receptor isoforms in adipose-derived stem cells. , 2015, Histology and histopathology.

[34]  H. Riess,et al.  Targeting multiple tyrosine kinase receptors with Dovitinib blocks invasion and the interaction between tumor cells and cancer-associated fibroblasts in breast cancer , 2015, Cell cycle.

[35]  K. Horwitz,et al.  Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling , 2014, BMC Cancer.

[36]  Gordon B Mills,et al.  Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer , 2014, Clinical Cancer Research.

[37]  L. Stalker,et al.  Inhibition of proliferation and migration of luminal and claudin-low breast cancer cells by PDGFR inhibitors , 2014, Cancer Cell International.

[38]  S. Sebti,et al.  Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours , 2014, British Journal of Cancer.

[39]  M. Iorio,et al.  PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells , 2014, Molecular oncology.

[40]  C. Criscitiello,et al.  Investigational platelet-derived growth factor receptor kinase inhibitors in breast cancer therapy , 2014, Expert opinion on investigational drugs.

[41]  C. Heldin,et al.  Targeting the PDGF signaling pathway in tumor treatment , 2013, Cell Communication and Signaling.

[42]  K. Fürst,et al.  E2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B. , 2013, Journal of molecular cell biology.

[43]  S. Schoppmann,et al.  Thrombocytes Correlate with Lymphangiogenesis in Human Esophageal Cancer and Mediate Growth of Lymphatic Endothelial Cells In Vitro , 2013, PloS one.

[44]  S. Steinberg,et al.  Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells. , 2013, The American journal of pathology.

[45]  Shi-hua Zhao,et al.  [The correlation between BRAF mutations, RET/PTC rearrangements and platelet-derived growth factor B expression in papillary thyroid carcinomas]. , 2012, Zhonghua nei ke za zhi.

[46]  G. Semenza,et al.  Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells , 2012, Proceedings of the National Academy of Sciences.

[47]  M. Dowsett,et al.  Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer , 2012, Breast Cancer Research.

[48]  Y. Tao,et al.  Platelet-Derived Growth Factor Regulates Breast Cancer Progression via β-Catenin Expression , 2011, Pathobiology.

[49]  F. Sarkar,et al.  Molecular markers of epithelial-to-mesenchymal transition are associated with tumor aggressiveness in breast carcinoma. , 2011, Translational oncology.

[50]  P. Galle,et al.  VEGF-D Correlates with Metastatic Disease in Gastric Cancer Patients Undergoing Surgery , 2011, World Journal of Surgery.

[51]  M. Rao,et al.  Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase , 2011, Cell.

[52]  T. Dønnem,et al.  Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size. , 2011, Clinical lung cancer.

[53]  K. Chayama,et al.  Expression of platelet‐derived growth factor (PDGF)‐B and PDGF‐receptor β is associated with lymphatic metastasis in human gastric carcinoma , 2010, Cancer science.

[54]  W. Jonat,et al.  In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells , 2010, BMC Cancer.

[55]  M. Raica,et al.  Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy , 2010, Pharmaceuticals.

[56]  T. Dønnem,et al.  Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.

[57]  S. Nishikawa,et al.  VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B. , 2009, American journal of physiology. Heart and circulatory physiology.

[58]  Johanna Andrae,et al.  Role of platelet-derived growth factors in physiology and medicine. , 2008, Genes & development.

[59]  C. Betsholtz,et al.  PDGF‐B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[60]  R. Xiang,et al.  A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma. , 2006, Vaccine.

[61]  G. Bergström,et al.  Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries. , 2006, Cardiovascular research.

[62]  C. Cordon-Cardo,et al.  Autocrine PDGFR signaling promotes mammary cancer metastasis. , 2006, The Journal of clinical investigation.

[63]  W. Cavenee,et al.  Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. , 2003, The American journal of pathology.

[64]  M. Israel,et al.  Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. , 2002, Cancer research.

[65]  E. Jannini,et al.  Expression of Platelet-Derived Growth Factor-A (PDGF-A), PDGF-B, and PDGF Receptor-α and -β during Human Testicular Development and Disease , 2002 .

[66]  C. Wells,et al.  Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. , 2000, Human pathology.

[67]  C. Garbe,et al.  Cytokines in human melanoma cells: synthesis, autocrine stimulation and regulatory functions—an overview , 1993, Melanoma research.

[68]  C. Heldin,et al.  Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. , 1992, Cancer research.

[69]  C. Heldin,et al.  Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. , 1991, The Journal of biological chemistry.

[70]  R. Coombes,et al.  Growth factor expression in Breast tissue , 1990, The Journal of Steroid Biochemistry and Molecular Biology.

[71]  S. Bates,et al.  Transforming Growth Factor-β Induces Platelet-Derived Growth Factor (PDGF) Messenger RNA and PDGF Secretion while Inhibiting Growth in Normal Human Mammary Epithelial Cells , 1990 .

[72]  C. Heldin,et al.  Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines. , 1987, Cancer research.

[73]  A. Czekierdowski,et al.  Proliferation and maturation of intratumoral blood vessels in women with malignant ovarian tumors assessed with cancer stem cells marker nestin and platelet derived growth factor PDGF-B. , 2017, Ginekologia polska.

[74]  Seung Woo Chung,et al.  LHT7, a chemically modified heparin, inhibits multiple stages of angiogenesis by blocking VEGF, FGF2 and PDGF-B signaling pathways. , 2015, Biomaterials.

[75]  Alyssa Bottrell.  The Role Of Pdgf C And Its Splice Variant In Breast Cancer , 2014 .

[76]  Y. Guo,et al.  Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B. , 2013, Neoplasma.

[77]  C. Betsholtz,et al.  Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. , 2009, Cancer research.

[78]  E. Jannini,et al.  Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease. , 2002, The Journal of clinical endocrinology and metabolism.

[79]  G. Hortobagyi,et al.  SIS/PDGF-B expression in benign and malignant human breast lesions. , 1989, Oncogene.