SPOT Synthesis — Scope of Applications

The currently very successful paradigm in scientific research of applying a systematic empirical search rather than an iterative rational design to solve complex scientific questions heavily relies on technologies that allow for a rapid and comprehensive screening of diverse types of molecular probes. Combinatorial chemical or biological synthesis applied to molecular biology, immunology and drug discovery was the technology that paved the way (Gallop et al. 1994). Massive miniaturization and automation are central and relevant topics in the further development of these technologies. A steady increase in the number of probes and samples that can be screened together with further reductions in the assay dimensions and costs readily allows for many new applications.

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