Smaller left hemisphere planum temporale in adults with autistic disorder

The structure of the planum temporale is often disturbed in disorders with associated communication problems, particularly in auditory and language processing areas in the brain. We hypothesized that people with autism would have reduced left hemisphere volumes in the planum temporale, a language related brain structure. We performed magnetic resonance imaging scans of 15 adults with autistic disorder and 15 comparison subjects, and measured the volume of gray matter in the planum temporale and Heschl's gyrus (HG) in both hemispheres. Planum temporale volume reduced in the left hemisphere of the autism group (P<0.003). No differences in HG volumes were observed between the two groups. The volume reduction seen in the left hemisphere of the autism group may suggest an early neurodevelopmental disturbance in autism that impacts language development.

[1]  R J Wise,et al.  Separate neural subsystems within 'Wernicke's area'. , 2001, Brain : a journal of neurology.

[2]  M. Annett.  Handedness and cerebral dominance: the right shift theory. , 1998, The Journal of neuropsychiatry and clinical neurosciences.

[3]  G D Pearlson,et al.  Reversal of asymmetry of the planum temporale in schizophrenia. , 1995, The American journal of psychiatry.

[4]  A. David,et al.  The planum temporale: a systematic, quantitative review of its structural, functional and clinical significance , 1999, Brain Research Reviews.

[5]  Torleiv Høien,et al.  MRI evaluation of the size and symmetry of the planum temporale in adolescents with developmental dyslexia , 1990, Brain and Language.

[6]  K. Colby,et al.  Handedness in autistic children , 1977, Journal of autism and childhood schizophrenia.

[7]  N. Rosman,et al.  Pneumographic findings in the infantile autism syndrome. A correlation with temporal lobe disease. , 1975, Brain : a journal of neurology.

[8]  C. Leonard,et al.  Brain morphology in children with specific language impairment. , 1997, Journal of speech, language, and hearing research : JSLHR.

[9]  Karl Herholz,et al.  Cerebral Networks and Functional Brain Asymmetry: Evidence from Regional Metabolic Changes during Word Repetition , 1998, Brain and Language.

[10]  J A Wada,et al.  Cerebral hemispheric asymmetry in humans. Cortical speech zones in 100 adults and 100 infant brains. , 1975, Archives of neurology.

[11]  G Pearlson,et al.  Small planum temporale volume in Down's syndrome: a volumetric MRI study. , 1997, The American journal of psychiatry.

[12]  Lutz Jancke,et al.  Child Age and Planum Temporale Asymmetry , 1999, Brain and Cognition.

[13]  B Mazoyer,et al.  Left planum temporale surface correlates with functional dominance during story listening* , 1998, Neuroreport.

[14]  M. Annett.  A classification of hand preference by association analysis. , 1970, British journal of psychology.

[15]  B S McCann,et al.  Hemispheric asymmetries and early infantile autism , 1982, Journal of autism and developmental disorders.

[16]  K M Heilman,et al.  Anomalous anatomy of speech–language areas in adults with persistent developmental stuttering , 2001, Neurology.

[17]  A. Couteur,et al.  Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders , 1994, Journal of autism and developmental disorders.

[18]  P. Teale,et al.  Sex-specific expression of Heschl's gyrus functional and structural abnormalities in paranoid schizophrenia. , 2015, The American journal of psychiatry.

[19]  B. Leventhal,et al.  The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism , 2000, Journal of autism and developmental disorders.