Concentration and Velocity Profiles of Blood Cells in the Microcirculation

Although this chapter basically deals with the concentration and velocity profiles of blood cells in general, most of the data presented concern blood platelets. These small blood cells, with a density close to that of blood plasma, can be nicely used as natural markers of flow by fluorescently labeling them in vivo allowing their localization and the assessment of blood flow velocities at various sites in microvessels. Because of their role in hemostasis, thrombosis, and maintaining endothelial cell integrity, blood platelets can be expected to come in contact with the vessel wall. Recent in vivo studies have shown that blood platelets indeed do come close to the wall in arterioles(1,2), but less so in venules. In the latter microvessels a relatively large zone near the vessel wall from which blood platelets seem to be expelled, has to be appreciated(2).

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