A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling

[1]  Chuanmin Tao,et al.  TIRAP C539T polymorphism contributes to tuberculosis susceptibility: evidence from a meta-analysis. , 2014, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

[2]  S. Gordon,et al.  The M1 and M2 paradigm of macrophage activation: time for reassessment , 2014, F1000prime reports.

[3]  K. Feingold The adverse effect of IFN gamma on stratum corneum structure and function in psoriasis and atopic dermatitis. , 2014, The Journal of investigative dermatology.

[4]  A. Iwasaki,et al.  A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction , 2014, Cell.

[5]  Takeshi Matsuzawa,et al.  Autophagy activation by interferon‐γ via the p38 mitogen‐activated protein kinase signalling pathway is involved in macrophage bactericidal activity , 2014, Immunology.

[6]  F. Shanahan,et al.  Identification of a Unique Hybrid Macrophage-Polarization State following Recovery from Lipopolysaccharide Tolerance , 2014, The Journal of Immunology.

[7]  A. Matteo,et al.  The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis , 2013, Genes and Immunity.

[8]  K. Morris,et al.  Interferon-γ and systemic autoimmunity. , 2013, Discovery medicine.

[9]  L. Ramakrishnan,et al.  TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species , 2013, Cell.

[10]  S. Mostowy,et al.  Faculty Opinions recommendation of Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. , 2013 .

[11]  Hardy Kornfeld,et al.  Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β , 2012, Nature Immunology.

[12]  K. Mills,et al.  Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion , 2012, The Journal of Immunology.

[13]  J. Casanova,et al.  Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency , 2012, Science.

[14]  J. Cox,et al.  Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway , 2012, Cell.

[15]  G. Martens,et al.  Hypercholesterolemic LDL receptor‐deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity , 2012, Journal of leukocyte biology.

[16]  J. MacMicking Interferon-inducible effector mechanisms in cell-autonomous immunity , 2012, Nature Reviews Immunology.

[17]  John P. Ray,et al.  Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections , 2012, Cell.

[18]  R. Zhong,et al.  TLR9 polymorphisms and systemic lupus erythematosus risk in Asians: a meta-analysis study. , 2012, Cytokine.

[19]  B. Nandi,et al.  Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection , 2011, The Journal of experimental medicine.

[20]  F. DiMaio,et al.  Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection , 2011, Proceedings of the National Academy of Sciences.

[21]  J. Keane,et al.  Autophagy in the immune response to tuberculosis: clinical perspectives , 2011, Clinical and experimental immunology.

[22]  M. Hibberd,et al.  Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[23]  Brijendra Singh,et al.  Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India. , 2010, Tuberculosis.

[24]  D. Golenbock,et al.  MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR31 , 2009, The Journal of Immunology.

[25]  Michael Levin,et al.  Polymorphic Variation in TIRAP Is Not Associated with Susceptibility to Childhood TB but May Determine Susceptibility to TBM in Some Ethnic Groups , 2009, PloS one.

[26]  E. Lavelle,et al.  Autophagy and the immune response to TB. , 2009, Transboundary and emerging diseases.

[27]  Lutz Hamann,et al.  Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock , 2009, Proceedings of the National Academy of Sciences.

[28]  B. Clotet,et al.  Secretion of interferon‐γ by human macrophages demonstrated at the single‐cell level after costimulation with interleukin (IL)‐12 plus IL‐18 , 2009, Immunology.

[29]  J. Anaya,et al.  TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. , 2008, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

[30]  J. Todd,et al.  Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations , 2008, Nature Genetics.

[31]  S. Akira,et al.  Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, ‐4 and ‐9 , 2008, European journal of immunology.

[32]  J. Keane,et al.  T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. , 2007, Immunity.

[33]  Giorgio Sirugo,et al.  A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis , 2007, Nature Genetics.

[34]  J. Casanova,et al.  Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features , 2006 .

[35]  D. Fuchs,et al.  Crucial Role of Interferon-γ and Stimulated Macrophages in Cardiovascular Disease , 2006 .

[36]  R. Medzhitov,et al.  Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling , 2006, Cell.

[37]  V. Deretic,et al.  Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism , 2006, Cellular microbiology.

[38]  A. Ding,et al.  MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA , 2006, Nature Immunology.

[39]  C. Bogdan,et al.  Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-gamma in IL-12/IL-18-stimulated mouse macrophage populations. , 2005, Blood.

[40]  V. Deretic,et al.  Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages , 2004, Cell.

[41]  R. Flavell,et al.  The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors , 2002, Nature.

[42]  S. Akira,et al.  Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 , 2002, Nature.

[43]  Lloyd J. Old,et al.  The roles of IFNγ in protection against tumor development and cancer immunoediting , 2002 .

[44]  Liang Tong,et al.  Faculty Opinions recommendation of Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. , 2001 .

[45]  Dirk E. Smith,et al.  Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction , 2001, Nature.

[46]  R. Medzhitov,et al.  TIRAP: an adapter molecule in the Toll signaling pathway , 2001, Nature Immunology.

[47]  Y. Moriyama,et al.  Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. , 1998, Cell structure and function.

[48]  M. Burdick,et al.  Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis , 1997, Infection and immunity.

[49]  T. Mosmann,et al.  Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. , 1995, Immunity.

[50]  F. Belardelli,et al.  Interferon gamma upregulates its own gene expression in mouse peritoneal macrophages , 1994, The Journal of experimental medicine.

[51]  J. Flynn,et al.  An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection , 1993, The Journal of experimental medicine.

[52]  S. Barber,et al.  Induction of IFN-γ in macrophages by lipopolysaccharide , 1993 .

[53]  S. Kaufmann,et al.  Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates , 1991, Infection and immunity.

[54]  L. Wilkinson Immunity , 1891, The Lancet.

[55]  R. Bucala,et al.  Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention. , 2009, Autoimmunity reviews.

[56]  A. Ding,et al.  MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. , 2006, Nature immunology.

[57]  D. Fuchs,et al.  Crucial role of interferon-gamma and stimulated macrophages in cardiovascular disease. , 2006, Current vascular pharmacology.

[58]  J. Casanova,et al.  Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features. , 2006, Seminars in immunology.

[59]  S. Barber,et al.  Induction of IFN-gamma in macrophages by lipopolysaccharide. , 1993, International immunology.

[60]  B. Perussia,et al.  Lymphokine-activated killer cells, natural killer cells and cytokines. , 1991, Current opinion in immunology.

[61]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.

[62]  I. Orme,et al.  Materials and Methods Briefdefinitive Report Disseminated Tuberculosis in Interferon 7 Gene-disrupted Mice , 2022 .