Use of a Polymeric Implant System to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol, a Human Metabolite of PCB 52, in Male Adolescent Rats.
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J. Ankrum | A. Adamcakova-Dodd | H. Lehmler | Xueshu Li | A. Klingelhutz | Amanda J Bullert | Hui Wang | Hanna Stevens | Peter S Thorne
[1] H. Lehmler,et al. Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intraperitoneal Exposure. , 2023, Environmental toxicology and pharmacology.
[2] Andres Martinez,et al. Structure–Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity , 2023, Chemical research in toxicology.
[3] J. Ankrum,et al. Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes. , 2023, Toxicology in vitro : an international journal published in association with BIBRA.
[4] Z. Ismail,et al. A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to? , 2022, International journal of environmental research and public health.
[5] C. Sandau,et al. A review of the mechanisms of by-product PCB formation in pigments, dyes and paints. , 2022, The Science of the total environment.
[6] H. Lehmler,et al. Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites , 2022, Environmental science & technology.
[7] T. Schettgen,et al. Decomposition Products of the Initiator Bis(2,4-dichlorobenzoyl)peroxide in the Silicone Industry: Human Biomonitoring in Plasma and Urine of Workers. , 2022, Environmental science & technology.
[8] Rachel F. Marek,et al. Assessment of Polychlorinated Biphenyls and Their Hydroxylated Metabolites in Postmortem Human Brain Samples: Age and Brain Region Differences , 2022, Environmental science & technology.
[9] A. Adamcakova-Dodd,et al. Toxicity Assessment of 91-Day Repeated Inhalation Exposure to an Indoor School Air Mixture of PCBs. , 2022, Environmental science & technology.
[10] H. Lehmler,et al. The Effects of Polychlorinated Biphenyl Exposure During Adolescence on the Nervous System: A Comprehensive Review , 2021, Chemical research in toxicology.
[11] Shu-Zhen Liu,et al. Effects of Polychlorinated Biphenyls on Animal Reproductive Systems and Epigenetic Modifications , 2021, Bulletin of Environmental Contamination and Toxicology.
[12] D. Keil,et al. Effects of an environmentally relevant PCB-mixture on immune function, clinical chemistry, and thyroid hormone levels in adult female B6C3F1 mice , 2020, Journal of toxicology and environmental health. Part A.
[13] N. Quinete,et al. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster , 2020, Scientific Reports.
[14] A. Adamcakova-Dodd,et al. Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs. , 2020, Environmental science & technology.
[15] Erqun Song,et al. A Critical Review of Polychlorinated Biphenyls Metabolism, Metabolites and Their Correlation with Oxidative Stress. , 2020, Chemical research in toxicology.
[16] P. Lein,et al. Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity , 2020, International journal of molecular sciences.
[17] P. Lein,et al. The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences , 2019, Environmental Science and Pollution Research.
[18] S. Tanabe,et al. Effects of PCB exposure on serum thyroid hormone levels in dogs and cats. , 2019, The Science of the total environment.
[19] G. Johnson,et al. Evaluation of the effectiveness of different indicator PCBs to estimating total PCB concentrations in environmental investigations. , 2019, Chemosphere.
[20] K.,et al. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[21] J. Schnoor,et al. Atropselective Disposition of 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) and Identification of Its Metabolites in Mice with Liver-specific Deletion of Cytochrome P450 Reductase. , 2019, Chemical research in toxicology.
[22] E. Roze,et al. Prenatal exposure to PCBs and neurological and sexual/pubertal development from birth to adolescence. , 2019, Current problems in pediatric and adolescent health care.
[23] S. Sagiv,et al. Neurotoxicity of polychlorinated biphenyls and related organohalogens , 2019, Acta Neuropathologica.
[24] B. Puschner,et al. Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor. , 2019, Environmental science & technology.
[25] H. Lehmler,et al. Toxicokinetics of Chiral PCB 136 and Its Hydroxylated Metabolites in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase. , 2019, Chemical research in toxicology.
[26] P. Guest,et al. The Y-Maze for Assessment of Spatial Working and Reference Memory in Mice. , 2018, Methods in molecular biology.
[27] M. Duffel,et al. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. , 2018, Environmental toxicology and pharmacology.
[28] Yao Dong,et al. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example , 2018, Environmental Science and Pollution Research.
[29] Nicholas J. Herkert,et al. Airborne PCBs and OH-PCBs Inside and Outside Urban and Rural U.S. Schools. , 2017, Environmental science & technology.
[30] H. Yamazaki,et al. Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl , 2016, Drug Metabolism and Disposition.
[31] M. Duffel,et al. Sulfation of Lower Chlorinated Polychlorinated Biphenyls Increases Their Affinity for the Major Drug-Binding Sites of Human Serum Albumin. , 2016, Environmental science & technology.
[32] A. Gore,et al. Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 1. Sexually dimorphic effects on social and anxiety-like behaviors , 2016, Hormones and Behavior.
[33] H. Lehmler,et al. Chiral polychlorinated biphenyls: absorption, metabolism and excretion—a review , 2016, Environmental Science and Pollution Research.
[34] E. Robinson,et al. Reducing the stress of drug administration: implications for the 3Rs , 2015, Scientific Reports.
[35] Fabian A. Grimm,et al. Metabolism and metabolites of polychlorinated biphenyls , 2015, Critical reviews in toxicology.
[36] T. Beach,et al. Role of Environmental Contaminants in the Etiology of Alzheimer's Disease: A Review , 2015, Current Alzheimer research.
[37] F. Aqil,et al. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants , 2014, Toxicology reports.
[38] P. Thorne,et al. Variability in PCB and OH-PCB Serum Levels in Children and Their Mothers in Urban and Rural U.S. Communities , 2014, Environmental science & technology.
[39] P. Heikkinen,et al. Toxicological Profile of Ultrapure 2,2′,3,4,4′,5,5′-Heptachlorbiphenyl (PCB 180) in Adult Rats , 2014, PloS one.
[40] A. Adamcakova-Dodd,et al. The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. , 2014, Environment international.
[41] S. Goldman. Environmental toxins and Parkinson's disease. , 2014, Annual review of pharmacology and toxicology.
[42] A. Adamcakova-Dodd,et al. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. , 2013, Environmental science & technology.
[43] P. Thorne,et al. PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities. , 2013, Environmental science & technology.
[44] F. Aqil,et al. Multi-layer polymeric implants for sustained release of chemopreventives. , 2012, Cancer letters.
[45] S. Lazic,et al. A call for transparent reporting to optimize the predictive value of preclinical research , 2012, Nature.
[46] F. Aqil,et al. Controlled-release systemic delivery - a new concept in cancer chemoprevention. , 2012, Carcinogenesis.
[47] C. Jang,et al. Lactational and postnatal exposure to polychlorinated biphenyls induces sex‐specific anxiolytic behavior and cognitive deficit in mice offspring , 2011, Synapse.
[48] A. Juhasz,et al. Assessment of Persistent Organic Pollutant (POP) Bioavailability and Bioaccessibility for Human Health Exposure Assessment: A Critical Review , 2011 .
[49] V. Felipo,et al. Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. mechanisms involved , 2010, Neuroscience.
[50] K. Hornbuckle,et al. Inadvertent Polychlorinated Biphenyls in Commercial Paint Pigments† , 2009, Environmental science & technology.
[51] D. Hutmacher,et al. The return of a forgotten polymer : Polycaprolactone in the 21st century , 2009 .
[52] H. Lehmler,et al. Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. , 2008, Journal of chromatography. A.
[53] A. Walf,et al. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents , 2007, Nature Protocols.
[54] J. Sacchettini,et al. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. , 2004, Chemistry & biology.
[55] I. Meerts,et al. Developmental exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): long-term effects on brain development, behavior, and brain stem auditory evoked potentials in rats. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.
[56] I. Meerts,et al. Effects of in utero exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female estrous cyclicity in rats. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.
[57] Chad B. Sandusky,et al. Laboratory routines cause animal stress. , 2004, Contemporary topics in laboratory animal science.
[58] R. Hughes. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory , 2004, Neuroscience & Biobehavioral Reviews.
[59] H. Lehmler,et al. Glucuronidation of hydroxylated polychlorinated biphenyls (PCBs). , 2002, Chemical research in toxicology.
[60] Abraham Brouwer,et al. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.
[61] H. Lehmler,et al. Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling. , 2001, Chemosphere.
[62] K Bester,et al. Preparation and certification of a reference material on PCBs in pig fat and its application in quality control in monitoring laboratories during the Belgian "PCB-crisis". , 2001, Chemosphere.
[63] P. Upton,et al. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5, 5'-tetrachlorobiphenyl. , 2000, Chemical research in toxicology.
[64] P. Ayotte,et al. Analysis of hydroxylated metabolites of PCBs (OH-PCBs) and other chlorinated phenolic compounds in whole blood from Canadian inuit. , 2000, Environmental health perspectives.
[65] I. Piechotowski,et al. PCB-blood levels in teachers, working in PCB-contaminated schools. , 2000, Chemosphere.
[66] H. Tilson,et al. The neurotoxicity of polychlorinated biphenyls. , 1998, Neurotoxicology.
[67] H. Takeda,et al. Changes in head-dipping behavior in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. , 1998, European journal of pharmacology.
[68] U. Bauer,et al. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. , 1996, Chemical research in toxicology.
[69] M. Feeley,et al. Toxicity of PCB 77 (3,3′,4,4′-Tetrachlorobiphenyl) and PCB 118 (2,3′,4,4′,5-Pentachlorobiphenyl) in the Rat Following Subchronic Dietary Exposure , 1995 .
[70] A. Bergman,et al. Selective retention of hydroxylated PCB metabolites in blood. , 1994, Environmental health perspectives.
[71] W. Shain,et al. Neurotoxicity of polychlorinated biphenyls: structure-activity relationship of individual congeners. , 1991, Toxicology and applied pharmacology.
[72] J. Hadgraft,et al. The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery , 1987 .
[73] C. Blake,et al. Structurally specific binding of halogenated biphenyls to thyroxine transport protein. , 1986, Journal of medicinal chemistry.
[74] T. Black. THE PREPARATION AND REACTIONS OF DIAZOMETHANE , 1983 .
[75] J. Miller,et al. Non-arene oxide aromatic ring hydroxylation of 2,2',5,5'-tetrachlorobiphenyl as the major metabolic pathway catalyzed by phenobarbital-induced rat liver microsomes. , 1983, The Journal of biological chemistry.
[76] 橘 敏明,et al. Open-Field Testの妥当性と信頼性 , 1983 .
[77] S. Forgue,et al. Identification of an arene oxide metabolite of 2,2',5-5'-tetrachlorobiphenyl by gas chromatography-mass spectroscopy. , 1982, Chemico-biological interactions.
[78] O. Hutzinger,et al. Reductive dechlorination of chlorobiphenylols by rats , 1977, Experientia.
[79] B. Jansson,et al. The metabolism of 2,2′,3,5′,6-pentachlorobiphenyl in rats, mice and quails , 1975 .
[80] O. Hutzinger,et al. Identification of metabolic dechlorination of highly chlorinated biphenyl in rabbit , 1974, Nature.
[81] A. Beyer,et al. Environmental fate and global distribution of polychlorinated biphenyls. , 2009, Reviews of environmental contamination and toxicology.
[82] H. Reich,et al. In vitro metabolism of [14C]4-chlorobiphenyl and [14C]2,2',5,5'-tetrachlorobiphenyl by hepatic microsomes from rats and pigeons. Evidence against an obligatory arene oxide in aromatic hydroxylation reactions. , 1991, The International journal of biochemistry.
[83] G. Pantaleoni,et al. Behavioral effects of PCBs in mice. , 1990, Behavioural pharmacology.