MYELOID NEOPLASIA PARP 1 is required for chromosomal translocations

Department of Medicine, University of Florida College of Medicine, Gainesville, FL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR; Department of Hematology, Memorial Sloan-Kettering Cancer Center, New York, NY; and Department of Environmental and Radiological Health Sciences, Colorado State

[1]  F. Alt,et al.  Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1) , 2012, Proceedings of the National Academy of Sciences.

[2]  A. Tutt,et al.  PARP inhibitors--current status and the walk towards early breast cancer. , 2011, Breast.

[3]  A. Tomkinson,et al.  Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway* , 2011, The Journal of Biological Chemistry.

[4]  R. Hromas,et al.  Synthetic lethality: exploiting the addiction of cancer to DNA repair. , 2011, Blood.

[5]  G. Iliakis,et al.  Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. , 2011, Mutation research.

[6]  Lei Zhang,et al.  DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation , 2011, PLoS genetics.

[7]  Yu Zhang,et al.  An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway , 2011, Nature Structural &Molecular Biology.

[8]  L. Hutchinson.  Targeted therapies: PARP inhibitor olaparib is safe and effective in patients with BRCA1 and BRCA2 mutations , 2010, Nature Reviews Clinical Oncology.

[9]  R. Hromas,et al.  The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations. , 2010, Cancer genetics and cytogenetics.

[10]  M. Jasin,et al.  Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4/ligase IV during chromosomal translocation formation , 2010, Nature Structural &Molecular Biology.

[11]  A. Ashworth,et al.  Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.

[12]  Fyodor Urnov,et al.  Chromosomal translocations induced at specified loci in human stem cells , 2009, Proceedings of the National Academy of Sciences.

[13]  B. Reina-San-Martin,et al.  Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination , 2009, The Journal of experimental medicine.

[14]  R. Hromas,et al.  Mechanisms of leukemia translocations , 2008, Current opinion in hematology.

[15]  D. Weinstock,et al.  Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70 , 2007, Nature Cell Biology.

[16]  S. Dey,et al.  Response to high LET radiation 12C (LET, 295 keV/μm) in M5 cells, a radio resistant cell strain derived from Chinese hamster V79 cells , 2007, International journal of radiation biology.

[17]  George Iliakis,et al.  PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways , 2006, Nucleic acids research.

[18]  D. Weinstock,et al.  Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells. , 2006, DNA repair.

[19]  J. Rowley,et al.  Chromatin structural elements and chromosomal translocations in leukemia. , 2006, DNA repair.

[20]  N. Osheroff,et al.  Topoisomerase II and the etiology of chromosomal translocations. , 2006, DNA repair.

[21]  D. Weinstock,et al.  A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. , 2006, Blood.

[22]  M. Jasin,et al.  Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. , 2005, Molecular cell.

[23]  M. Gellert,et al.  The taming of a transposon: V(D)J recombination and the immune system , 2004, Immunological reviews.

[24]  D. Gilliland,et al.  Genetics of myeloid leukemias. , 2003, Annual review of genomics and human genetics.

[25]  Christine Richardson,et al.  Frequent chromosomal translocations induced by DNA double-strand breaks , 2000, Nature.

[26]  P. Chambon,et al.  Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.