One-Pot Synthesis, Antioxidant Activity and Toxicity Evaluation of Some Hydroxyxanthones

За допомогою одностадійої реакції цикло- дегідрування похідних гідроксибензенової кислоти (саліцилова або резорцилова кислота) з флороглюціном або пірогалолом у присутності реагенту Ітона (P2O5/MeSO3H) одержано нові сполуки гідроксиксантону. Для визначення інгібуючої концентрації (IC50) синтезованих сполук їх антиокиснювальну активність перевірено за допомогою 2,2-дифеніл-1-пікрилгід- разилу. Цитотоксичність отриманих сполук оцінено MТT- тестом на лінії клітин Vero. Встановлено, що положення та кількість гідроксильних груп можуть суттєво вплинути на потенційну антиокиснювальну активність приготовлених сполук. Показано, що синтезовані сполуки гідроксиксантону можна класифікувати як сильні антиоксиданти та їх можна використовувати в промисловості.

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