Fingolimod modulates microglial activation to augment markers of remyelination

[1]  S. Ludwin,et al.  Neurobiological effects of sphingosine 1‐phosphate receptor modulation in the cuprizone model , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  G. Giovannoni,et al.  Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis , 2011, Multiple sclerosis.

[3]  E. Lo,et al.  Fingolimod provides long‐term protection in rodent models of cerebral ischemia , 2011, Annals of neurology.

[4]  M. Zurich,et al.  Inflammatory responses in aggregating rat brain cell cultures subjected to different demyelinating conditions , 2010, Brain Research.

[5]  D. Rowitch,et al.  Overcoming remyelination failure in multiple sclerosis and other myelin disorders , 2010, Experimental Neurology.

[6]  S. Ludwin,et al.  Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. , 2010, The American journal of pathology.

[7]  W. Alexander.  American academy of neurology: 62nd annual meeting. , 2010, P & T : a peer-reviewed journal for formulary management.

[8]  H. Hartung,et al.  Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis , 2010, Trends in Neurosciences.

[9]  F. Tse,et al.  Quantitative determination of BAF312, a S1P-R modulator, in human urine by LC-MS/MS: prevention and recovery of lost analyte due to container surface adsorption. , 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  J. Richardson,et al.  FTY720 ameliorates MOG‐induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses , 2010, Journal of neuroscience research.

[11]  T. Neumann-Haefelin,et al.  The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. , 2009, Biochemical and biophysical research communications.

[12]  T. Chomiak,et al.  What Is the Optimal Value of the g-Ratio for Myelinated Fibers in the Rat CNS? A Theoretical Approach , 2009, PloS one.

[13]  C. Teunissen,et al.  An in vitro model for de‐ and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures , 2009, Glia.

[14]  Steven J Brown,et al.  Sphingosine 1-phosphate receptor signaling. , 2009, Annual review of biochemistry.

[15]  A. Sheikh,et al.  Lysophosphatidylcholine induces glial cell activation: Role of rho kinase , 2009, Glia.

[16]  C. A. Foster,et al.  FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood‐Brain‐Barrier Damage , 2009, Brain pathology.

[17]  A. Chédotal,et al.  Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells , 2009, Annals of neurology.

[18]  J. Antel,et al.  Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies , 2008, Clinical Neurology and Neurosurgery.

[19]  A. Sorenson,et al.  Myelinated, synapsing cultures of murine spinal cord – validation as an in vitro model of the central nervous system , 2008, The European journal of neuroscience.

[20]  Jeffery A. Hall,et al.  Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. , 2008, The American journal of pathology.

[21]  H. Schluesener,et al.  Early attenuation of lesional interleukin‐16 up‐regulation by dexamethasone and FTY720 in experimental traumatic brain injury , 2008, Neuropathology and applied neurobiology.

[22]  J. Antel,et al.  FTY720 modulates human oligodendrocyte progenitor process extension and survival , 2008, Annals of neurology.

[23]  H. J. Kim,et al.  Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells , 2007, Glia.

[24]  E. Persohn,et al.  Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis , 2007, Journal of Pharmacology and Experimental Therapeutics.

[25]  S. Payne,et al.  The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors , 2007, Journal of Pharmacology and Experimental Therapeutics.

[26]  M. Schwab,et al.  Phosphorylated FTY720 promotes astrocyte migration through sphingosine‐1‐phosphate receptors , 2007, Journal of neurochemistry.

[27]  V. Brinkmann.  Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. , 2007, Pharmacology & therapeutics.

[28]  K. Dev,et al.  Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors , 2007, Neuropharmacology.

[29]  H. Schluesener,et al.  FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury , 2007, Journal of cellular and molecular medicine.

[30]  S. David,et al.  T cells contribute to lysophosphatidylcholine‐induced macrophage activation and demyelination in the CNS , 2007, Glia.

[31]  A. Schwab,et al.  Lysophosphatidylcholine Stimulates IL-1β Release from Microglia via a P2X7 Receptor-Independent Mechanism1 , 2006, The Journal of Immunology.

[32]  N. Gray,et al.  A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. , 2006, Chemistry & biology.

[33]  Ludwig Kappos,et al.  Oral fingolimod (FTY720) for relapsing multiple sclerosis. , 2006, The New England journal of medicine.

[34]  Ueli Suter,et al.  β1-Integrin Signaling Mediates Premyelinating Oligodendrocyte Survival But Is Not Required for CNS Myelination and Remyelination , 2006, The Journal of Neuroscience.

[35]  M. Cuzner,et al.  Cannabinoid-receptor 1 null mice are susceptible to neurofilament damage and caspase 3 activation , 2005, Neuroscience.

[36]  S. Spiegel,et al.  Novel role of sphingosine kinase 1 as a mediator of neurotrophin‐3 action in oligodendrocyte progenitors , 2005, Journal of neurochemistry.

[37]  M. Koyama,et al.  FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. , 2005, Cellular & molecular immunology.

[38]  E. Francotte,et al.  Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. , 2005, Journal of medicinal chemistry.

[39]  D. Baker,et al.  Cannabinoids and neuroprotection in CNS inflammatory disease , 2005, Journal of the Neurological Sciences.

[40]  M. Cuzner,et al.  Cannabinoid‐mediated neuroprotection following interferon‐gamma treatment in a three‐dimensional mouse brain aggregate cell culture , 2004, The European journal of neuroscience.

[41]  M. Resh,et al.  Signaling from Integrins to Fyn to Rho Family GTPases Regulates Morphologic Differentiation of Oligodendrocytes , 2004, The Journal of Neuroscience.

[42]  J. Chun,et al.  Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice , 2004, Journal of Neuroimmunology.

[43]  M. Cuzner,et al.  Remyelination of cytokine‐ or antibody‐demyelinated CNS aggregate cultures is inhibited by macrophage supplementation , 2004, Glia.

[44]  T. Rao,et al.  Microglial activation state and lysophospholipid acid receptor expression , 2003, International Journal of Developmental Neuroscience.

[45]  H. Amemiya,et al.  Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment , 2003, Journal of Pharmacology and Experimental Therapeutics.

[46]  C. Polman,et al.  Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. , 2002, Brain : a journal of neurology.

[47]  Michael D. Davis,et al.  The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors* , 2002, The Journal of Biological Chemistry.

[48]  A. Omori,et al.  Study of expression of myelin basic proteins (MBPs) in developing rat brain using a novel antibody reacting with four major isoforms of MBP , 2002, Journal of neuroscience research.

[49]  Chad A. Cowan,et al.  Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. , 2000, Development.

[50]  S. Ousman,et al.  Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord , 2000, Glia.

[51]  Y. Oyama,et al.  Cytotoxic actions of FTY720, a novel immunosuppressant, on thymocytes and brain neurons dissociated from the rat. , 1998, Japanese journal of pharmacology.

[52]  D. N. Landon,et al.  Myelination and remyelination of aggregate rat brain cell cultures enriched with macrophages , 1997, Journal of neuroscience research.

[53]  S. Enosawa,et al.  Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720. , 1996, Immunopharmacology.

[54]  W. Blakemore,et al.  Remyelination of mouse spinal cord axons demyelinated by local injection of lysolecithin , 1995, Journal of neurocytology.

[55]  M. Cuzner,et al.  Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: Effects of macrophage enrichment , 1994, Journal of neuroscience research.

[56]  G. M. Hope,et al.  Maintenance of myelinated fibre g ratio in acute experimental allergic encephalomyelitis. , 1991, Brain : a journal of neurology.

[57]  W. Matthews,et al.  McAlpine's multiple sclerosis , 1985 .

[58]  K. Smith,et al.  Saltatory conduction precedes remyelination in axons demyelinated with lysophosphatidyl choline , 1982, Journal of the Neurological Sciences.

[59]  N. Baumann,et al.  Neurological Mutations Affecting Myelination , 1981 .

[60]  B. Trapp,et al.  Morphological differentiation of mechanically dissociated fetal rat brain in aggregating cell cultures , 1979, Brain Research.

[61]  C. Campagnoni,et al.  Developmental changes in the basic proteins of normal and jimpy mouse brain. , 1972, Biochemical and biophysical research communications.

[62]  W. L. Benedict,et al.  Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.