Deletion mutagenesis of stem cell factor defines the C-terminal sequences essential for its biological activity.

[1]  H. Broxmeyer,et al.  The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. , 1991, Cancer cells.

[2]  I. Pastan,et al.  Recombinant toxins for cancer treatment. , 1991, Science.

[3]  K. Zsebo,et al.  Hematologic effects of stem cell factor in vivo and in vitro in rodents. , 1991, Blood.

[4]  J. Wypych,et al.  Amino acid sequence and post-translational modification of stem cell factor isolated from buffalo rat liver cell-conditioned medium. , 1991, The Journal of biological chemistry.

[5]  J. Bazan Genetic and structural homology of stem cell factor and macrophage colony-stimulating factor , 1991, Cell.

[6]  P. Leder,et al.  Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant , 1991, Cell.

[7]  K. Zsebo,et al.  Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. , 1991, Experimental hematology.

[8]  O. Witte Steel locus defines new multipotent growth factor , 1990, Cell.

[9]  K. Zsebo,et al.  Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium , 1990, Cell.

[10]  David A. Williams,et al.  Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor , 1990, Cell.

[11]  C. March,et al.  Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms , 1990, Cell.

[12]  K. Nocka,et al.  Candidate ligand for the c‐kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. , 1990, The EMBO journal.

[13]  K. Miyazono,et al.  Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin , 1989, Journal of cellular physiology.

[14]  M. Takahashi,et al.  Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF. , 1989, Biochemical and biophysical research communications.

[15]  S. Nishikawa,et al.  B lymphopoiesis on stromal cell clone: stromal cell clones acting on different stages of B cell differentiation* , 1988, European journal of immunology.

[16]  K. Mullis,et al.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. , 1988, Science.

[17]  K. Arai,et al.  SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat , 1988, Molecular and cellular biology.

[18]  M. Roussel,et al.  Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes , 1987, Molecular and cellular biology.

[19]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[20]  T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[21]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[22]  C. March,et al.  Cloning, sequence and expression of human interleukin-2 receptor , 1984, Nature.