In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells.

[1]  D. Spandidos,et al.  Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo , 2017, Oncology reports.

[2]  D. Spandidos,et al.  Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines , 2015, Oncology letters.

[3]  S. Edwards,et al.  Phytopharmacy - An evidence-based guide to herbal medicinal products , 2015, Zeitschrift für Phytotherapie.

[4]  D. P. de Sousa,et al.  Antitumor Activity of Monoterpenes Found in Essential Oils , 2014, TheScientificWorldJournal.

[5]  C. G. Harman,et al.  Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes. , 2014, Chemical research in toxicology.

[6]  A. Mantha,et al.  Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View , 2014, BioMed research international.

[7]  S. Camus,et al.  Performance of comet and micronucleus assays in metabolic competent HepaRG cells to predict in vivo genotoxicity. , 2014, Toxicological Sciences.

[8]  Samuele Vannini,et al.  Investigation of the cytotoxic, genotoxic, and apoptosis-inducing effects of estragole isolated from fennel (Foeniculum vulgare). , 2014, Journal of natural products.

[9]  F. Paumgartten,et al.  Traditional use and safety of herbal medicines , 2014 .

[10]  P. Restani,et al.  Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[11]  A. Tsatsakis,et al.  Assessment of polyphenolic content, antioxidant activity, protection against ROS-induced DNA damage and anticancer activity of Vitis vinifera stem extracts. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[12]  S. Monarca,et al.  Evaluation of In Vitro Cytoxicity and Genotoxicity of Size-Fractionated Air Particles Sampled during Road Tunnel Construction , 2013, BioMed research international.

[13]  O. Cioancă,et al.  The chemical composition of essential oils isolated from sweet fennel fruits available as herbal tea products. , 2013, Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.

[14]  A. Vannacci,et al.  Can Estragole in Fennel Seed Decoctions Really Be Considered a Danger for Human Health? A Fennel Safety Update , 2012, Evidence-based complementary and alternative medicine : eCAM.

[15]  F. Atienzar,et al.  Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins , 2012, Cell Biology and Toxicology.

[16]  Andreas P. Freidig,et al.  Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[17]  Wout Slob,et al.  Risk assessment of botanicals and botanical preparations intended for use in food and food supplements: emerging issues. , 2008, Toxicology letters.

[18]  B. Aggarwal,et al.  Potential of Spice-Derived Phytochemicals for Cancer Prevention , 2008, Planta medica.

[19]  M. Fenech Cytokinesis-block micronucleus cytome assay , 2007, Nature Protocols.

[20]  A. Collins,et al.  The comet assay for DNA damage and repair , 2004, Molecular biotechnology.

[21]  Frank Stahl,et al.  Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[22]  J I Goodman,et al.  Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[23]  S. K. Abraham,et al.  Anti-genotoxicity of trans-anethole and eugenol in mice. , 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  C. S. Weil,et al.  The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[25]  P. van Bladeren,et al.  Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drug-metabolizing enzymes in the rat liver. , 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[26]  J. Caldwell,et al.  Metabolism of estragole in rat and mouse and influence of dose size on excretion of the proximate carcinogen 1'-hydroxyestragole. , 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[27]  J. Caldwell,et al.  The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers. , 1987, Xenobiotica; the fate of foreign compounds in biological systems.

[28]  O. Sugita,et al.  Drug metabolism by the human hepatoma cell, Hep G2. , 1987, Biochemical and biophysical research communications.

[29]  E C Miller,et al.  Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1'-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver. , 1983, Cancer research.

[30]  E C Miller,et al.  Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. , 1983, Cancer research.

[31]  T. Wilson,et al.  Nutritional Health: Strategies for Disease Prevention , 2023, Nutrition and Health.

[32]  K. Kang,et al.  HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics , 2014, Archives of Pharmacal Research.

[33]  Soo-Jin Jeong,et al.  Anethole exerts antimetatstaic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways. , 2011, Biological & pharmaceutical bulletin.

[34]  R. Tice,et al.  Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing , 2000, Environmental and molecular mutagenesis.

[35]  J D Tucker,et al.  Identification of aneuploidy‐inducing agents using cytokinesis‐blocked human lymphocytes and an antikinetochore antibody , 1989, Environmental and molecular mutagenesis.