Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney

Abstract1.Renal handling of pig-and rat-insulin was studied in the isolated perfused rat kidney.2.Metabolic clearance rates of both pig- and rat-insulin excceded GFR.3.Peritubular uptake of pig-insulin accounted for 13%, of rat-insulin for 31% of the total metabolic clearance.4.The nonfiltering kidney does not remove insulin from the peritubular circulation.5.Metabolic clearance rates of pig- and rat-insulin are directly related to GFR.6.The filtration process seems to be necessary for the uptake of insulin at the peritubular site.

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