Quantitative assessment of parkinsonian and essential tremor

Triaxial accelerometry was used to study various motion characteristics in 10 patients with Parkinson disease and 11 patients with essential tremor. The smoothness of motion factor (SPMEF) and the acceleration waveform factor (TIPAR) were frequently and consistently abnormal. When both factors were analyzed together and compared with a control population, 100% of the left arm and 88% of the right arm values were abnormal in the Parkinson disease group, and 82% of the left arm and 91% of the right arm values were abnormal in the essential tremor patients. Repeat evaluation revealed consistent intrapatient results. Therefore, this technique may provide an objective assessment of movement disorders.

[1]  G. Holmes THE SYMPTOMS OF ACUTE CEREBELLAR INJURIES DUE TO GUNSHOT INJURIES , 1917 .

[2]  G. Holmes THE CEREBELLUM OF MAN , 1939 .

[3]  R. Schwab,et al.  Action tremor and the cogwheel phenomenon in Parkinson's disease. , 1963, Brain : a journal of neurology.

[4]  J. Lance,et al.  Physiological tremor. , 1968, Lancet.

[5]  R. Young,et al.  Non-resting tremor in Parkinson's disease. , 1971, Transactions of the American Neurological Association.

[6]  R W Pew,et al.  Quantification of hand tremor in the clinical neurological examination. , 1973, IEEE transactions on bio-medical engineering.

[7]  J. Whittier,et al.  Cineseismography: a method for measuring abnormal involuntary movements of the human body. , 1974, Diseases of the nervous system.

[8]  P D Neilson,et al.  Measurement of involuntary arm movement in athetotic patients , 1974, Journal of neurology, neurosurgery, and psychiatry.

[9]  R L Hewer,et al.  Intention tremor--a method of measurement. , 1975, Journal of neurology, neurosurgery, and psychiatry.

[10]  W. Markesbery,et al.  Suppression of essential tremor by propranolol: Correlation of effect with drug plasma levels and intensity of beta‐adrenergic blockade , 1977, Annals of neurology.

[11]  R. Elble,et al.  Mechanistic components of normal hand tremor. , 1978, Electroencephalography and clinical neurophysiology.

[12]  James D. Frost,et al.  Triaxial Vector Accelerometry: A Method for Quantifying Tremor and Ataxia , 1978, IEEE Transactions on Biomedical Engineering.

[13]  J. Jankovic,et al.  Physiologic and pathologic tremors. Diagnosis, mechanism, and management. , 1980, Annals of internal medicine.