Underreporting of vertebral fractures on routine chest radiography.

OBJECTIVE Osteoporosis is underdiagnosed and therefore undertreated. We determined the potential usefulness of chest radiography for detecting clinically important vertebral fractures by performing semiquantitative reviews and quantitative digital morphometry on 100 routine chest radiographs taken in the emergency department and comparing the yield of these independent reviews with official radiology reports. MATERIALS AND METHODS One hundred randomly selected chest radiographs of patients 60 years or older who presented to the emergency department of a tertiary care hospital were evaluated. Radiographs were selected without knowledge of the presenting complaint and were independently reviewed by two board-certified radiologists and a radiology resident. A validated semiquantitative method was used to assess lateral chest radiographs for vertebral fracture. In addition, quantitative digital morphometry was undertaken. A clinically important vertebral fracture was defined as one that was at least moderate to severe (loss of height >or=> 25%). RESULTS Mean age of the population was 75 years, 47% were women, and 46% were admitted to the hospital. According to the reference radiologist, prevalence of moderate to severe vertebral fractures was 22%. Simple agreement was 87-88% among reviewers; kappa values were moderate (0.56-0.58). The greatest agreement was between the reference standard radiologist and quantitative digital morphometry (89% agreement; kappa = 0.67). Only 55% (12/22) of vertebral fractures we identified were mentioned in the official radiology reports. CONCLUSION Chest radiography has potential as a screening tool for revealing previously undiagnosed vertebral fractures, although in this study only half of moderate to severe fractures that we identified were mentioned in official reports.

[1]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[2]  M. Hooper,et al.  Randomized Trial of the Effects of Risedronate on Vertebral Fractures in Women with Established Postmenopausal Osteoporosis , 2000, Osteoporosis International.

[3]  H. Genant,et al.  Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women , 1993, Osteoporosis International.

[4]  R. Epstein,et al.  Pre-existing fractures and bone mass predict vertebral fracture incidence in women. , 1991, Annals of internal medicine.

[5]  P. Ross,et al.  Clinical consequences of vertebral fractures. , 1997, The American journal of medicine.

[6]  S. Majumdar,et al.  Development and Initial Validation of a Risk Score for Predicting In‐Hospital and 1‐Year Mortality in Patients With Hip Fractures , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  Richard Platt,et al.  Low frequency of treatment of osteoporosis among postmenopausal women following a fracture. , 2003, Archives of internal medicine.

[8]  S. Gehlbach,et al.  Recognition of Vertebral Fracture in a Clinical Setting , 2000, Osteoporosis International.

[9]  Jacques P. Brown,et al.  Determinants of health-related quality of life in women with vertebral fractures , 2005, Osteoporosis International.

[10]  C. Roux,et al.  Reporting of vertebral fractures on spine X-rays , 2005, Osteoporosis International.

[11]  H K Genant,et al.  Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. , 1999, JAMA.

[12]  S. Cummings,et al.  Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. , 2000, The Journal of clinical endocrinology and metabolism.

[13]  T. Link,et al.  Radiologic assessment of osteoporotic vertebral fractures: diagnostic and prognostic implications , 2005, European Radiology.

[14]  C C Glüer,et al.  Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. , 1999, JAMA.

[15]  C. Cooper,et al.  Incidence of clinically diagnosed vertebral fractures: A population‐based study in rochester, minnesota, 1985‐1989 , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  M. Dobritz,et al.  Detection of osteoporotic vertebral fractures using multidetector CT , 2005, Osteoporosis International.

[17]  S. A. Jackson,et al.  Vertebral Fracture Definition from Population-Based Data: Preliminary Results from the Canadian Multicenter Osteoporosis Study (CaMos) , 2000, Osteoporosis International.

[18]  M. Nevitt,et al.  Vertebral fracture assessment using a semiquantitative technique , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.