BAG3 regulates stability of IL-8 mRNA via interplay between HuR and miR-4312 in PDACs

[1]  Yan Wang,et al.  SEMA4D under the posttranscriptional regulation of HuR and miR-4319 boosts cancer progression in esophageal squamous cell carcinoma , 2020, Cancer biology & therapy.

[2]  S. Filetti,et al.  The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells , 2019, Scientific Reports.

[3]  Nooreen Dabbish,et al.  Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer: A Post-hoc Analysis From the International Phase III ESPAC-3 Clinical Trial , 2018, Annals of surgery.

[4]  H. Yao,et al.  BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells , 2017, Journal of Cell Biology.

[5]  M. Hidalgo,et al.  Pancreatic ductal adenocarcinoma: metastatic disease , 2017, Clinical and Translational Oncology.

[6]  Chao Zhang,et al.  RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1 , 2017, OncoTargets and therapy.

[7]  R. Houlgatte,et al.  Cytoplasmic overexpression of RNA‐binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia , 2017, The Journal of pathology.

[8]  M. Jackson,et al.  CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression , 2016, Oncotarget.

[9]  P. S. Ray,et al.  Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress , 2016, RNA biology.

[10]  S. Bose,et al.  Regulation of nucleolin expression by miR-194, miR-206, and HuR , 2016, Molecular and Cellular Biochemistry.

[11]  H. Saiyin,et al.  IL-8–Positive Tumor-Infiltrating Inflammatory Cells Are a Novel Prognostic Marker in Pancreatic Ductal Adenocarcinoma Patients , 2016, Pancreas.

[12]  D. Kruger,et al.  Cytokines as Biomarkers of Pancreatic Ductal Adenocarcinoma: A Systematic Review , 2016, PloS one.

[13]  Haidong Xu,et al.  BAG3 regulates cell proliferation, migration, and invasion in human colorectal cancer , 2016, Tumor Biology.

[14]  M. Gorospe,et al.  H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR , 2016, Molecular and Cellular Biology.

[15]  M. Gorospe,et al.  Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637 , 2015, Molecular and Cellular Biology.

[16]  G. Gonye,et al.  Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells , 2015, Oncotarget.

[17]  P. S. Ray,et al.  RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4 , 2015, Oncogene.

[18]  U. Wolfrum,et al.  Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function , 2015, Cell Death and Disease.

[19]  M. Sherman,et al.  Hsp70 in cancer: back to the future , 2014, Oncogene.

[20]  Lianyu Chen,et al.  The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases , 2014, Scientific Reports.

[21]  T. Hagemann,et al.  Inflammatory cytokines in human pancreatic cancer. , 2014, Cancer letters.

[22]  M. Turco,et al.  BAG3 protein expression in melanoma metastatic lymph nodes correlates with patients' survival , 2014, Cell Death and Disease.

[23]  Y. Totsuka,et al.  Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions , 2014, Oncology reports.

[24]  Z. Zong,et al.  BAG3 is upregulated by c-Jun and stabilizes JunD. , 2013, Biochimica et biophysica acta.

[25]  Yun Wu,et al.  Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy , 2013, Breast Cancer Research and Treatment.

[26]  B. Wilhelm,et al.  HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA , 2013, Nature Communications.

[27]  Jitendra K Thakur,et al.  The interplay of HuR and miR-3134 in regulation of AU rich transcriptome , 2013, RNA biology.

[28]  Fan Yang,et al.  Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a. , 2013, Cellular signalling.

[29]  Cong Zhang,et al.  Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer , 2013, Tumor Biology.

[30]  H. Kalthoff,et al.  TRAIL-induced expression of uPA and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells. , 2013, Hepatobiliary & pancreatic diseases international : HBPD INT.

[31]  E. Corsini,et al.  Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin , 2012, Archives of Toxicology.

[32]  D. Dixon,et al.  The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2 , 2011, Molecular Cancer Research.

[33]  R. Agami,et al.  MicroRNA regulation by RNA-binding proteins and its implications for cancer , 2011, Nature Reviews Cancer.

[34]  S. Srikantan,et al.  Competitive Regulation of Nucleolin Expression by HuR and miR-494 , 2011, Molecular and Cellular Biology.

[35]  R. Franco,et al.  BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. , 2011, The American journal of pathology.

[36]  Tsuyoshi Saito,et al.  BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells. , 2011, Cancer letters.

[37]  John Calvin Reed,et al.  BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion. , 2010, Biochemical and biophysical research communications.

[38]  L. Shantz,et al.  Cytoplasmic Accumulation of the RNA-binding Protein HuR Stabilizes the Ornithine Decarboxylase Transcript in a Murine Nonmelanoma Skin Cancer Model* , 2010, The Journal of Biological Chemistry.

[39]  W. Filipowicz,et al.  Regulation of mRNA translation and stability by microRNAs. , 2010, Annual review of biochemistry.

[40]  E. Lam,et al.  The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours. , 2010, Cytokine.

[41]  S. Park,et al.  HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol. , 2009, Toxicology and applied pharmacology.

[42]  E. Kohn,et al.  Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3—modulated adhesion and invasion , 2009, The Journal of pathology.

[43]  D. Wong,et al.  AUF1 and HuR Proteins Stabilize Interleukin-8 mRNA in Human Saliva , 2008, Journal of dental research.

[44]  Kotb Abdelmohsen,et al.  Nuclear HuR accumulation through phosphorylation by Cdk1. , 2008, Genes & development.

[45]  H. Lou,et al.  Diverse molecular functions of Hu proteins , 2008, Cellular and Molecular Life Sciences.

[46]  R. Agami,et al.  Interplay between microRNAs and RNA-binding proteins determines developmental processes , 2008, Cell cycle.

[47]  J. Pfeilschifter,et al.  Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA , 2008, Molecular and Cellular Biology.

[48]  Reuven Agami,et al.  RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA , 2007, Cell.

[49]  John Calvin Reed,et al.  BAG3 regulates motility and adhesion of epithelial cancer cells. , 2007, Cancer research.

[50]  A. Gentilella,et al.  Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein. , 2007, The international journal of biochemistry & cell biology.

[51]  J. Keene.  RNA regulons: coordination of post-transcriptional events , 2007, Nature Reviews Genetics.

[52]  Heinfried H Radeke,et al.  Protein Kinase C-dependent Phosphorylation of the mRNA-stabilizing Factor HuR : Implications for Posttranscriptional Regulation of Cyclooxygenase-2 , 2007 .

[53]  M. Todaro,et al.  The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. , 2007, The Journal of clinical endocrinology and metabolism.

[54]  Kotb Abdelmohsen,et al.  Phosphorylation of HuR by Chk2 regulates SIRT1 expression. , 2007, Molecular cell.

[55]  E. Kohn,et al.  CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. , 2006, Experimental cell research.

[56]  H. Joensuu,et al.  Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. , 2005, Cancer research.

[57]  Shuang Huang,et al.  Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability , 2005, Cell.

[58]  M. Gorospe,et al.  AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin α1 , 2004, Journal of Biological Chemistry.

[59]  C. Haglund,et al.  Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. , 2003, Cancer research.

[60]  Andrew J. Dannenberg,et al.  Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes , 2003, Journal of Biological Chemistry.

[61]  E. Kohn,et al.  BAG3 Protein Regulates Cell Survival in Childhood Acute Lymphoblastic Leukemia Cells , 2003, Cancer biology & therapy.

[62]  S. Venuta,et al.  BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis , 2003, Cell Death and Differentiation.

[63]  M. Gorospe,et al.  AMP-Activated Kinase Regulates Cytoplasmic HuR , 2002, Molecular and Cellular Biology.

[64]  H. Friess,et al.  The anti‐apoptotic protein BAG‐3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines , 2001, FEBS letters.

[65]  John Calvin Reed,et al.  An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators* , 1999, The Journal of Biological Chemistry.

[66]  A. Shyu,et al.  RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein , 1998, The EMBO journal.

[67]  H. Kocher,et al.  Pancreatic Cancer , 2019, Methods in Molecular Biology.

[68]  Cong Zhang,et al.  Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma , 2013, Tumor Biology.