Current Status of Standardization of Inhalant Allergen Extracts in Korea

Allergy diagnosis and immunotherapy in Korea rely mostly on imported allergen extracts. However, some allergens that are not important in Western countries are not commercially available, and even the same species of allergen source often displays differences in allergenicity due to amino acid sequence polymorphisms. Therefore, it is essential to prepare allergen extracts that reflect regional characteristics. Allergen standardization has been performed since 2009 with the support of the Korea Center for Disease Control and Prevention. Here, we summarize the current status of allergen standardization, focusing on the house dust mite and cockroach. Pollen allergens that are under investigation are also briefly described.

[1]  C. Hong,et al.  The Effects of Storage Conditions on the Stability of House Dust Mite Extracts , 2013, Allergy, asthma & immunology research.

[2]  Jungwon Park,et al.  Identification of Novel Allergenic Components from German Cockroach Fecal Extract by a Proteomic Approach , 2013, International Archives of Allergy and Immunology.

[3]  C. Hong,et al.  Preparation and Characterization of an Extract of German Cockroach From a Korean Source , 2012, Allergy, asthma & immunology research.

[4]  J H Lee,et al.  Allergenicity of recombinant profilins from Japanese hop, Humulus japonicus. , 2013, Journal of investigational allergology & clinical immunology.

[5]  J. Y. Kim,et al.  Alveolar Macrophages Play a Key Role in Cockroach-Induced Allergic Inflammation via TNF-α Pathway , 2012, PloS one.

[6]  L. Arlian,et al.  Population growth and allergen accumulation of Dermatophagoides farinae cultured at 20 and 25 °C , 2012, Experimental and Applied Acarology.

[7]  C. Hong,et al.  House Dust Mite Allergy in Korea: The Most Important Inhalant Allergen in Current and Future , 2012, Allergy, asthma & immunology research.

[8]  L. Arlian,et al.  Diet Influences Growth Rates and Allergen and Endotoxin Contents of Cultured Dermatophagoides farinae and Dermatophagoides pteronyssinus House Dust Mites , 2012, International Archives of Allergy and Immunology.

[9]  In‐Yong Lee,et al.  Sequence polymorphisms of Der f 1, Der p 1, Der f 2 and Der p 2 from Korean house dust mite isolates , 2012, Experimental and Applied Acarology.

[10]  In‐Yong Lee,et al.  Standardization of House Dust Mite Extracts in Korea , 2012, Allergy, asthma & immunology research.

[11]  Eun Ju Lee,et al.  Responses of Two Invasive Plants Under Various Microclimate Conditions in the Seoul Metropolitan Region , 2012, Environmental Management.

[12]  Jae Hyun Lee,et al.  Endotoxin Is Not Essential for the Development of Cockroach Induced Allergic Airway Inflammation , 2012, Yonsei medical journal.

[13]  R. Treudler.  Update on in vitro allergy diagnostics , 2012, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[14]  Kyurang Kim,et al.  The Revised Edition of Korean Calendar for Allergenic Pollens , 2011, Allergy, asthma & immunology research.

[15]  P. Briza,et al.  Bet v 1‐like pollen allergens of multiple Fagales species can sensitize atopic individuals , 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[16]  Jun-seok Park,et al.  Analysis of Landscape Planting in Gangwon-do , 2011 .

[17]  C. Hong,et al.  Optimization of Allergen Standardization , 2011, Yonsei medical journal.

[18]  N. Indrawattana,et al.  Quantification of Der f 1 in houses of patients allergic to house dust mite, Dermatophagoides farinae, using a locally produced detection reagents. , 2011, Asian Pacific journal of allergy and immunology.

[19]  Y. Ye,et al.  Changes in Sensitization Rates to Pollen Allergens in Allergic Patients in the Southern Part of Gyeonggi Province Over the Last 10 Years , 2011 .

[20]  Hyun-Je Cho,et al.  Ecological comparison of Mongolian oak (Quercus mongolica Fisch. ex Ledeb.) community between Mt. Nam and Mt. Jeombong as a Long Term Ecological Research (LTER) site , 2011 .

[21]  S. Spector,et al.  Allergen immunotherapy: a practice parameter third update. , 2007, The Journal of allergy and clinical immunology.

[22]  L. Arlian,et al.  Population growth and allergen accumulation of Dermatophagoides pteronyssinus cultured at 20 and 25°C , 2011, Experimental and Applied Acarology.

[23]  K. Jeong,et al.  Enzymatic activities of allergen extracts from three species of dust mites and cockroaches commonly found in Korean home. , 2010, The Korean journal of parasitology.

[24]  L. Antonicelli,et al.  Characterization and comparison of commercially available mite extracts for in vivo diagnosis , 2010, Allergy.

[25]  C. Webber,et al.  Oral allergy syndrome: a clinical, diagnostic, and therapeutic challenge. , 2010, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[26]  Jae-Won Oh.  Development of Pollen Concentration Prediction Models , 2009 .

[27]  R. Van Ree,et al.  The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines. , 2008, The Journal of allergy and clinical immunology.

[28]  C. Hong,et al.  Domestic arthropods and their allergens. , 2007, Protein and peptide letters.

[29]  C. Hong,et al.  Sequence Polymorphisms of Major German Cockroach Allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5 , 2007, International Archives of Allergy and Immunology.

[30]  R. Ree,et al.  Indoor allergens: relevance of major allergen measurements and standardization. , 2007, The Journal of allergy and clinical immunology.

[31]  R. Van Ree,et al.  Indoor allergens: relevance of major allergen measurements and standardization. , 2007, The Journal of allergy and clinical immunology.

[32]  J Mullol,et al.  Air pollution and allergens. , 2007, Journal of investigational allergology & clinical immunology.

[33]  C. Hongb,et al.  Recombinant allergens for diagnosis and immunotherapy of allergic disorders, with emphasis on cockroach allergy. , 2006, Current protein & peptide science.

[34]  Ai Tao,et al.  Cloning, expression, and characterization of pollen allergens from Humulus scandens (Lour) Merr and Ambrosia artemisiifolia L , 2005, Acta Pharmacologica Sinica.

[35]  M. Perzanowski,et al.  Sub‐lethal exposure of cockroaches to boric acid pesticide contributes to increased Bla g 2 excretion , 2005, Allergy.

[36]  C. Schal,et al.  Expression, production and excretion of Bla g 1, a major human allergen, in relation to food intake in the German cockroach, Blattella germanica , 2005, Medical and veterinary entomology.

[37]  A. Enayati,et al.  Insect glutathione transferases and insecticide resistance , 2005, Insect molecular biology.

[38]  C. W. Kim,et al.  Der p 2 isoallergens have different allergenicity, and quantification with 2‐site ELISA using monoclonal antibodies is influenced by the isoallergens , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[39]  박중원,et al.  Der p 2 isoallergens have different allergenicity and quantification with 2-site ELISA using monoclonal antibodies is influenced by the isoallergens , 2002 .

[40]  D. Sheehan,et al.  Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. , 2001, The Biochemical journal.

[41]  Ennis,et al.  THE ROLE OF COCKROACH ALLERGY AND EXPOSURE TO COCKROACH ALLERGEN IN CAUSING MORBIDITY AMONG INNER-CITY CHILDREN WITH ASTHMA , 2000 .

[42]  Hong,et al.  Identification and characterization of the major allergen of the Humulus japonicus pollen , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[43]  C. Suh,et al.  Evidence of Hop Japanese pollinosis in Korea: IgE sensitization and identification of allergenic components. , 1997, The Journal of allergy and clinical immunology.

[44]  C. H. Meyer,et al.  Comparison of the levels of the major allergens Der p I and Der p II in standardized extracts of the house dust mite, Dermatophagoides pteronyssinus , 1994, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[45]  H. Park,et al.  Survey of airborne pollens in Seoul, Korea. , 1994, Journal of Korean medical science.

[46]  B. Nilsen,et al.  Cross-reactivity between pollen extracts from six artemisia species. , 1993, Planta medica.

[47]  K. Hahm,et al.  Identification and partial purification of pollen allergens from Artemisia princeps. , 1989, Yonsei medical journal.

[48]  J. Fox,et al.  Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). , 1989, The Journal of allergy and clinical immunology.

[49]  H. J. Kim,et al.  Survey of the airborne pollens in Seoul, Korea. , 1986, Yonsei medical journal.

[50]  R. M. Ford.  Allergy in asthma , 1982 .