Size and shape control in the overgrowth of gold nanorods

We report on a new sustainable approach to manipulate the optical behaviour and geometrical properties of gold nanorods in aqueous solutions by fine control of their overgrowth. In our approach, the overgrowth is realized by modulation of the reduction of the gold ions which are left as Au1+ after the primary step of the synthesis (typically as much as ~80% of the gold ions available in the growth solution). The progress of the reduction requires the gradual addition of ascorbic acid, which transforms the Au1+ into Au0 and may be performed in the original growth solution with no need for any further manipulation. By control of the total amount and rate of administration of the ascorbic acid, we prove the possibility to realize a systematic modulation of the average lengths, diameters, shapes (rod or dog-bone like), and light extinction of the nanoparticles. A slow overgrowth leads to a gradual enlargement of the lengths and diameters at almost constant shape. In contrast, a faster overgrowth results into a more complex modification of the overall shape of the gold nanorods.

[1]  Michael J. Ford,et al.  Tunable infrared absorption by metal nanoparticles: The case for gold rods and shells , 2008 .

[2]  Valery V Tuchin,et al.  Photoacoustic flow cytometry: principle and application for real-time detection of circulating single nanoparticles, pathogens, and contrast dyes in vivo. , 2007, Journal of biomedical optics.

[3]  Philip S Low,et al.  In vitro and in vivo two-photon luminescence imaging of single gold nanorods. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Massoud Motamedi,et al.  High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system. , 2007, Nano letters.

[5]  P. Jain,et al.  Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. , 2006, The journal of physical chemistry. B.

[6]  B. Korgel,et al.  The importance of the CTAB surfactant on the colloidal seed-mediated synthesis of gold nanorods. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[7]  B. N. Khlebtsov,et al.  Gold nanorods: Synthesis and optical properties , 2006 .

[8]  Ekaterina Lukianova,et al.  Selective laser nano‐thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles , 2006, Lasers in surgery and medicine.

[9]  B. Nikoobakht,et al.  種結晶を媒介とした成長法を用いた金ナノロッド(NR)の調製と成長メカニズム , 2003 .

[10]  Modulation of Optical Properties of Gold Nanorods on Addition of KOH , 2007 .

[11]  M. Möller,et al.  Structural evolution of gold nanorods during controlled secondary growth. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[12]  Weihai Ni,et al.  Tailoring longitudinal surface plasmon wavelengths, scattering and absorption cross sections of gold nanorods. , 2008, ACS nano.

[13]  Ji-Xin Cheng,et al.  Hyperthermic effects of gold nanorods on tumor cells. , 2007, Nanomedicine.

[14]  Daxiang Cui,et al.  Study on interaction between gold nanorod and bovine serum albumin , 2007 .

[15]  Joseph Irudayaraj,et al.  Identity profiling of cell surface markers by multiplex gold nanorod probes. , 2007, Nano letters.

[16]  Ji-Xin Cheng,et al.  Gold Nanorods Mediate Tumor Cell Death by Compromising Membrane Integrity , 2007, Advanced materials.

[17]  Prashant K. Jain,et al.  Plasmonic photothermal therapy (PPTT) using gold nanoparticles , 2008, Lasers in Medical Science.

[18]  Mostafa A. El-Sayed,et al.  Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method , 2003 .

[19]  Sulabha K. Kulkarni,et al.  Plasmon-assisted photonics at the nanoscale , 2007 .

[20]  C. Murphy,et al.  Anisotropic metal nanoparticles: Synthesis, assembly, and optical applications. , 2005, The journal of physical chemistry. B.

[21]  Takuro Niidome,et al.  Surface modification of gold nanorods using layer-by-layer technique for cellular uptake , 2008 .

[22]  Paul L Carson,et al.  Photoacoustic tomography of joints aided by an Etanercept-conjugated gold nanoparticle contrast agent—an ex vivo preliminary rat study , 2008, Nanotechnology.

[23]  Roberto Pini,et al.  Gold Nanoparticles : Engineering Photothermal effects in connective tissues mediated by laser-activated gold nanorods , 2009 .

[24]  Mark A. Anastasio,et al.  3D photoacoustic imaging , 2010, Photonics North.

[25]  Sarah C. Baxter,et al.  Using gold nanorods to probe cell-induced collagen deformation. , 2007, Nano letters.

[26]  Arezou A Ghazani,et al.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. , 2006, Nano letters.

[27]  Matthew O'Donnell,et al.  Photoacoustic imaging of early inflammatory response using gold nanorods , 2007 .

[28]  M. El-Sayed.  Spectroscopic determination of the melting energy of a gold nanorod , 2001 .

[29]  Xiaohua Huang,et al.  Peptide-conjugated gold nanorods for nuclear targeting. , 2007, Bioconjugate chemistry.

[30]  D. Astruc,et al.  Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. , 2004, Chemical reviews.

[31]  Wei Qian,et al.  Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: a potential cancer diagnostic marker. , 2007, Nano letters.

[32]  Mostafa A. El-Sayed,et al.  Surface-enhanced Raman scattering of molecules adsorbed on gold nanorods: off-surface plasmon resonance condition , 2002 .

[33]  K. Sokolov,et al.  Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods. , 2007, Nano letters.

[34]  Hristina Petrova,et al.  On the temperature stability of gold nanorods: comparison between thermal and ultrafast laser-induced heating. , 2006, Physical chemistry chemical physics : PCCP.

[35]  Paul Mulvaney,et al.  Gold nanorods: Synthesis, characterization and applications , 2005 .

[36]  Dakrong Pissuwan,et al.  Targeted destruction of murine macrophage cells with bioconjugated gold nanorods , 2007 .

[37]  Sabine Neuss,et al.  Size-dependent cytotoxicity of gold nanoparticles. , 2007, Small.

[38]  Catherine J Murphy,et al.  Seeded high yield synthesis of short Au nanorods in aqueous solution. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[39]  Xuchuan Jiang,et al.  Gold nanorods : Limitations on their synthesis and optical properties , 2006 .

[40]  D. Shieh,et al.  Photoacoustic Imaging of Multiple Targets Using Gold Nanorods , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[41]  A. V. Alekseeva,et al.  Preparation and optical scattering characterization of gold nanorods and their application to a dot-immunogold assay. , 2005, Applied optics.

[42]  Vladimir P. Zharov,et al.  Microbubbles-overlapping mode for laser killing of cancer cells with absorbing nanoparticle clusters , 2005 .

[43]  Catherine J. Murphy,et al.  Fine-tuning the shape of gold nanorods , 2005 .

[44]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.