Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans

This study tested the hypothesis, in a prospective cohort study design, that maternal saturated free fatty acid (sFFA) concentration during pregnancy is prospectively associated with offspring (newborn) hypothalamic (HTH) microstructure and to explore the functional relevance of this association with respect to early‐childhood body fat percentage (BF%).

[1]  J. Brüning,et al.  Maternal Metabolic Programming of the Developing Central Nervous System: Unified Pathways to Metabolic and Psychiatric Disorders , 2021, Biological Psychiatry.

[2]  S. Entringer,et al.  Fetal programming of human energy homeostasis brain networks: Issues and considerations , 2021, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[3]  Andrew M. Collings,et al.  The MDAR (Materials Design Analysis Reporting) Framework for transparent reporting in the life sciences , 2021, Proceedings of the National Academy of Sciences.

[4]  N. Volkow,et al.  The Healthy Brain and Child Development Study-Shedding Light on Opioid Exposure, COVID-19, and Health Disparities. , 2020, JAMA psychiatry.

[5]  C. Thiel,et al.  Automated diffusion-based parcellation of the hypothalamus reveals subunit-specific associations with obesity , 2020, Scientific Reports.

[6]  S. Ozanne,et al.  Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways , 2020, Molecular metabolism.

[7]  P. Schrauwen,et al.  Exercising your fat (metabolism) into shape: a muscle-centred view , 2020, Diabetologia.

[8]  A. Villringer,et al.  Higher body mass index is linked to altered hypothalamic microstructure , 2019, Scientific Reports.

[9]  L. Velloso,et al.  Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity , 2019, International Journal of Obesity.

[10]  C. Le Foll Hypothalamic Fatty Acids and Ketone Bodies Sensing and Role of FAT/CD36 in the Regulation of Food Intake , 2019, Front. Physiol..

[11]  T. Buchanan,et al.  Children Exposed to Maternal Obesity or Gestational Diabetes Mellitus During Early Fetal Development Have Hypothalamic Alterations That Predict Future Weight Gain , 2019, Diabetes Care.

[12]  S. Bouret,et al.  Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring , 2019, bioRxiv.

[13]  Daniel Rueckert,et al.  Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project , 2019, NeuroImage.

[14]  Martin Styner,et al.  Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life , 2019, NeuroImage.

[15]  J. Speakman The evolution of body fatness: trading off disease and predation risk , 2018, Journal of Experimental Biology.

[16]  Wolfgang M Pauli,et al.  Descriptor : A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei , 2018 .

[17]  A. Drewnowski,et al.  Obesity Pathogenesis: An Endocrine Society Scientific Statement. , 2017, Endocrine reviews.

[18]  B. Barres,et al.  Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. , 2017, Cell metabolism.

[19]  P. Rosenstiel,et al.  Hypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors , 2017, Diabetes.

[20]  S. Bain,et al.  Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial. , 2017, The lancet. Diabetes & endocrinology.

[21]  M. Styner,et al.  A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans , 2017, International Journal of Developmental Neuroscience.

[22]  S. Entringer,et al.  Association of maternal prepregnancy BMI with metabolomic profile across gestation , 2017, International Journal of Obesity.

[23]  Dong Won Kim,et al.  Maternal obesity leads to increased proliferation and numbers of astrocytes in the developing fetal and neonatal mouse hypothalamus , 2016, International Journal of Developmental Neuroscience.

[24]  S. Entringer,et al.  Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy , 2015, PloS one.

[25]  S. Ozanne,et al.  Early life origins of metabolic disease: Developmental programming of hypothalamic pathways controlling energy homeostasis , 2015, Frontiers in Neuroendocrinology.

[26]  Ghazala Begum,et al.  Developmental programming of hypothalamic neuronal circuits: impact on energy balance control , 2015, Front. Neurosci..

[27]  Gregory Traversy,et al.  Alcohol Consumption and Obesity: An Update , 2015, Current Obesity Reports.

[28]  T. Vrijkotte,et al.  Maternal Prepregancy BMI and Lipid Profile during Early Pregnancy Are Independently Associated with Offspring's Body Composition at Age 5–6 Years: The ABCD Study , 2014, PloS one.

[29]  Michael R. Kramer,et al.  Incidence of childhood obesity in the United States. , 2014, The New England journal of medicine.

[30]  M. Blüher,et al.  Association between Plasma Nonesterified Fatty Acids Species and Adipose Tissue Fatty Acid Composition , 2013, PloS one.

[31]  D. Dabelea,et al.  Role of developmental overnutrition in pediatric obesity and type 2 diabetes. , 2013, Nutrition reviews.

[32]  M. Dietrich,et al.  Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance , 2013, Cell.

[33]  Thomas R. Knösche,et al.  White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI , 2013, NeuroImage.

[34]  B. Koletzko,et al.  Nonesterified fatty acid determination for functional lipidomics: comprehensive ultrahigh performance liquid chromatography-tandem mass spectrometry quantitation, qualification, and parameter prediction. , 2012, Analytical chemistry.

[35]  M. Dietrich,et al.  Obesity is associated with hypothalamic injury in rodents and humans. , 2012, The Journal of clinical investigation.

[36]  B. Koletzko,et al.  Placental transfer of fatty acids and fetal implications. , 2011, The American journal of clinical nutrition.

[37]  F. Karpe,et al.  Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation , 2011, Diabetes.

[38]  D. Finegood,et al.  Implications of the Foresight Obesity System Map for Solutions to Childhood Obesity , 2010, Obesity.

[39]  Guang Sun,et al.  Comparison of the Classification of Obesity by BMI vs. Dual‐energy X‐ray Absorptiometry in the Newfoundland Population , 2009, Obesity.

[40]  J. Carvalheira,et al.  Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity , 2009, The Journal of Neuroscience.

[41]  S. Leibowitz,et al.  Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity , 2008, The Journal of Neuroscience.

[42]  S. O’Rahilly,et al.  Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions , 2008, Diabetes.

[43]  Y. Loh,et al.  Faculty Opinions recommendation of Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. , 2008 .

[44]  M. Karin,et al.  Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity , 2008, Cell.

[45]  S. Matthews,et al.  Fetal programming of hypothalamo‐pituitary‐adrenal function: prenatal stress and glucocorticoids , 2006, The Journal of physiology.

[46]  C. Beaulieu,et al.  The basis of anisotropic water diffusion in the nervous system – a technical review , 2002, NMR in biomedicine.

[47]  K. Narayan,et al.  Type 2 diabetes in children , 2001, BMJ : British Medical Journal.

[48]  E. Riboli,et al.  Reliability of fatty acid composition in human serum phospholipids , 2000, European Journal of Clinical Nutrition.