Pruritus in liver disease – pathenogenisis and treatment

Pruritus often constitutes a most irritating ailment in patients suff ering from chronic liver diseases, especially when cholestasis plays a prominent role. The exact pathogenesis is not entirely recognized. Nevertheless, several mechanisms have been proposed: pruritus connected with a central/peripheral origin, itch caused by mast cells’ hyperactivity, or determined by the intrahepatic cholestasis of pregnancy. This article concentrates on the pruritus accompanying advanced liver disorders. Its pathogenesis and treatment are also discussed.

[1]  O. Chazouilleres.  MARS: The ultimate warrior against pruritus of cholestasis? , 2010, Journal of hepatology.

[2]  K. Rifai.  Extracorporeal albumin dialysis , 2008, Hepatology research : the official journal of the Japan Society of Hepatology.

[3]  M. Steinhoff,et al.  How best to fight that nasty itch – from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches , 2005, Experimental dermatology.

[4]  N. Bergasa.  Treatment of the pruritus of cholestasis , 2004, Current treatment options in gastroenterology.

[5]  L. Poston,et al.  Glutathione S‐transferase and liver function in intrahepatic cholestasis of pregnancy and pruritus gravidarum , 2004, Hepatology.

[6]  A. Baird,et al.  Cholestatic pruritus – the role of cutaneous mast cells and nerves , 2004, Alimentary pharmacology & therapeutics.

[7]  A. Reuben.  Old scratch , 2004, Hepatology.

[8]  N. Bergasa.  Pruritus in chronic liver disease: Mechanisms and treatment , 2004, Current gastroenterology reports.

[9]  K. Lindor,et al.  Management of primary biliary cirrhosis , 2003, Current treatment options in gastroenterology.

[10]  U. Beuers,et al.  Extrahepatic manifestations of cholestasis , 2002, Journal of gastroenterology and hepatology.

[11]  D. Alling,et al.  Open‐label trial of oral nalmefene therapy for the pruritus of cholestasis , 1998, Hepatology.

[12]  Y. Bacq,et al.  Intrahepatic cholestasis of pregnancy: A French prospective study , 1997, Hepatology.

[13]  A. Burroughs,et al.  Review article: pruritus in cholestatic and other liver diseases. , 2003, Alimentary pharmacology & therapeutics.

[14]  Z. Żylicz,et al.  Pruritus in advanced internal diseases. Pathogenesis and treatment. , 2001, The Netherlands journal of medicine.