Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors.

[1]  W. Frishman,et al.  Pharmacologic Inhibition of Squalene Synthase and Other Downstream Enzymes of the Cholesterol Synthesis Pathway: A New Therapeutic Approach to Treatment of Hypercholesterolemia , 2009, Cardiology in review.

[2]  A. Kourounakis,et al.  Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. , 2008, Journal of medicinal chemistry.

[3]  J. Burnett Drug evaluation: TAK-475--an oral inhibitor of squalene synthase for hyperlipidemia. , 2006, Current opinion in investigational drugs.

[4]  T. Walley,et al.  Trends in prescribing and utilization of statins and other lipid lowering drugs across Europe 1997-2003. , 2005, British journal of clinical pharmacology.

[5]  J. Yadav,et al.  Iodine as novel reagent for the 1,2-addition of trimethylsilyl cyanide to ketones including α,β-unsaturated ketones , 2002 .

[6]  H. Mabuchi,et al.  Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities. , 2002, Bioorganic & medicinal chemistry.

[7]  A. Fujishima,et al.  Syntheses of fused heterocyclic compounds and their inhibitory activities for squalene synthase. , 2002, Bioorganic & Medicinal Chemistry.

[8]  R. Dean,et al.  Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. , 2000, Journal of lipid research.

[9]  T. Theophanides,et al.  SUPRAMOLECULAR ASSEMBLIES CONTAINING NUCLEIC BASES AND MAGNESIUM(II) HEXAHYDRATE IONS , 1997 .

[10]  K. Kövér,et al.  Simple, Safe, Large Scale Synthesis of 5-Arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-Arylpropanoic Acids , 1995 .

[11]  B. Halliwell,et al.  Lipids and oxidised lipids in human atheroma and normal aorta. , 1993, Biochimica et biophysica acta.

[12]  Robert E. Johnson,et al.  Synthesis of novel tetrahydrobenzazepinones , 1992 .

[13]  R. Schwesinger,et al.  Peralkylated Polyaminophosphazenes— Extremely Strong, Neutral Nitrogen Bases , 1987 .

[14]  T. Satoh,et al.  [Reduction of organic compounds with sodium borohydride-transition metal salt systems. 3. Preparation of 2-aminomethyl-1,1-diphenyl-1-butene]. , 1970, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[15]  G. Simchen,et al.  Reaktionen mit Halogenwasserstoffaddukten der Nitrile, I. Eine neue Isochinolinsynthese , 1969 .

[16]  K. F. Schmidt Über den Imin-Rest , 1924 .