Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors.
暂无分享,去创建一个
[1] W. Frishman,et al. Pharmacologic Inhibition of Squalene Synthase and Other Downstream Enzymes of the Cholesterol Synthesis Pathway: A New Therapeutic Approach to Treatment of Hypercholesterolemia , 2009, Cardiology in review.
[2] A. Kourounakis,et al. Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. , 2008, Journal of medicinal chemistry.
[3] J. Burnett. Drug evaluation: TAK-475--an oral inhibitor of squalene synthase for hyperlipidemia. , 2006, Current opinion in investigational drugs.
[4] T. Walley,et al. Trends in prescribing and utilization of statins and other lipid lowering drugs across Europe 1997-2003. , 2005, British journal of clinical pharmacology.
[5] J. Yadav,et al. Iodine as novel reagent for the 1,2-addition of trimethylsilyl cyanide to ketones including α,β-unsaturated ketones , 2002 .
[6] H. Mabuchi,et al. Novel 4,1-benzoxazepine derivatives with potent squalene synthase inhibitory activities. , 2002, Bioorganic & medicinal chemistry.
[7] A. Fujishima,et al. Syntheses of fused heterocyclic compounds and their inhibitory activities for squalene synthase. , 2002, Bioorganic & Medicinal Chemistry.
[8] R. Dean,et al. Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. , 2000, Journal of lipid research.
[9] T. Theophanides,et al. SUPRAMOLECULAR ASSEMBLIES CONTAINING NUCLEIC BASES AND MAGNESIUM(II) HEXAHYDRATE IONS , 1997 .
[10] K. Kövér,et al. Simple, Safe, Large Scale Synthesis of 5-Arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-Arylpropanoic Acids , 1995 .
[11] B. Halliwell,et al. Lipids and oxidised lipids in human atheroma and normal aorta. , 1993, Biochimica et biophysica acta.
[12] Robert E. Johnson,et al. Synthesis of novel tetrahydrobenzazepinones , 1992 .
[13] R. Schwesinger,et al. Peralkylated Polyaminophosphazenes— Extremely Strong, Neutral Nitrogen Bases , 1987 .
[14] T. Satoh,et al. [Reduction of organic compounds with sodium borohydride-transition metal salt systems. 3. Preparation of 2-aminomethyl-1,1-diphenyl-1-butene]. , 1970, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
[15] G. Simchen,et al. Reaktionen mit Halogenwasserstoffaddukten der Nitrile, I. Eine neue Isochinolinsynthese , 1969 .
[16] K. F. Schmidt. Über den Imin-Rest , 1924 .