A surface-micromachined optical self-homodyne polarimetric sensor for noninvasive glucose monitoring

A surface micromachined, highly sensitive optical polarimetric sensor using a self-homodyne coherent detection method has been demonstrated. By detecting the small polarization rotation of polarized laser light passing through a glucose-containing fluid, this sensor is suitable for noninvasive glucose monitoring for diabetes patients. A resolution glucose level of 75 mg/dl has been obtained, with a 0.9956 correlation coefficient between the reference and the measured values. This polarimeter has the advantages of full system integration and compatibility with silicon processing industry, which makes an integrated, low-cost noninvasive glucose sensor feasible.

[1]  R P Jackson,et al.  Physical and Chemical Methods of Sugar Analysis , 1942 .

[2]  Victor M. Bright,et al.  Implementation of hexagonal micromirror arrays as phase-mostly spatial light modulators , 1995, Photonics West - Micro and Nano Fabricated Electromechanical and Optical Components.

[3]  G. Coté,et al.  Noninvasive glucose sensing utilizing a digital closed-loop polarimetric approach , 1997, IEEE Transactions on Biomedical Engineering.

[4]  Kristofer S. J. Pister,et al.  Micro-machined three-dimensional micro-optics for integrated free-space optical system , 1994, IEEE Photonics Technology Letters.

[5]  C. Pu,et al.  Surface micromachined integrated optic polarization beam splitter , 1998 .

[6]  Y. Huang,et al.  Noninvasive glucose monitoring in vivo with an optical heterodyne polarimeter. , 1998, Applied optics.

[7]  M. A. Michalicek,et al.  Design and characterization of next-generation micromirrors fabricated in a four-level, planarized surface-micromachined polycrystalline silicon process , 1997 .

[8]  R. Maboudian,et al.  Self-assembled fluorocarbon films for enhanced stiction reduction , 1997, Proceedings of International Solid State Sensors and Actuators Conference (Transducers '97).

[9]  Mark R. Riley,et al.  Matrix-Enhanced Calibration Procedure for Multivariate Calibration Models with Near-Infrared Spectra , 1998 .

[10]  M. Feld,et al.  Feasibility of measuring blood glucose concentration by near-infrared Raman spectroscopy. , 1997, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.