Sex differences in cerebral injury after severe haemorrhage and ventricular fibrillation in pigs

Background: Experimental studies of haemorrhagic shock have documented a superior haemodynamic response and a better outcome in female animals as compared with male controls. Such sexual dimorphism has, nevertheless, not been reported after circulatory arrest that follows exsanguination and shock. We aimed to study differences in cerebral injury markers after exsanguination cardiac arrest in pre‐pubertal piglets. The hypothesis was that cerebral injury is less extensive in female animals, and that this difference is independent of sexual hormones or choice of resuscitative fluid.

[1]  K. Sunde,et al.  Scandinavian Clinical practice guidelines for therapeutic hypothermia and post‐resuscitation care after cardiac arrest , 2009, Acta anaesthesiologica Scandinavica.

[2]  R. Neumar,et al.  Consensus Process , 2022 .

[3]  L. McCullough,et al.  Pathways to ischemic neuronal cell death: are sex differences relevant? , 2008, Journal of Translational Medicine.

[4]  W. Ummenhofer,et al.  Cardiac arrest during anesthesia , 2008, Current opinion in critical care.

[5]  S. L. Mehta,et al.  Molecular Mechanisms of Apoptosis in Cerebral Ischemia: Multiple Neuroprotective Opportunities , 2008, Molecular Neurobiology.

[6]  I. Chaudry,et al.  Trauma and immune response--effect of gender differences. , 2007, Injury.

[7]  W. Malorni,et al.  Redox features of the cell: a gender perspective. , 2007, Antioxidants & redox signaling.

[8]  Z. Spolarics.  THE X-FILES OF INFLAMMATION: CELLULAR MOSAICISM OF X-LINKED POLYMORPHIC GENES AND THE FEMALE ADVANTAGE IN THE HOST RESPONSE TO INJURY AND INFECTION , 2007, Shock.

[9]  Lars Wiklund,et al.  Methylene blue added to a hypertonic–hyperoncotic solution increases short-term survival in experimental cardiac arrest* , 2006, Critical care medicine.

[10]  D. Lockey,et al.  Traumatic cardiac arrest: who are the survivors? , 2006, Annals of emergency medicine.

[11]  I. Chaudry,et al.  GENDER DIFFERENCES IN ACUTE RESPONSE TO TRAUMA-HEMORRHAGE , 2005, Shock.

[12]  S. Basu,et al.  Circulatory Arrest as a Model for Studies of Global Ischemic Injury and Neuroprotection , 2005, Annals of the New York Academy of Sciences.

[13]  L. McCullough,et al.  Ischemic Nitric Oxide and Poly (ADP-Ribose) Polymerase-1 in Cerebral Ischemia: Male Toxicity, Female Protection , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  L. F. Poli de Figueiredo,et al.  Small volume hypertonic resuscitation of circulatory shock. , 2005, Clinics.

[15]  H. Sharma.  Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. , 2005, Current pharmaceutical design.

[16]  K. Meldrum,et al.  Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury. , 2005, American journal of physiology. Endocrinology and metabolism.

[17]  S. Vannucci,et al.  Adult or Perinatal Brain Injury: Does Sex Matter? , 2005, Stroke.

[18]  A. Kher,et al.  SEX DIFFERENCES IN THE MYOCARDIAL INFLAMMATORY RESPONSE TO ACUTE INJURY , 2005, Shock.

[19]  Jun Chen,et al.  Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms , 2004, Neurological research.

[20]  A. Hoeft,et al.  Effects of hypertonic versus isotonic infusion therapy on regional cerebral blood flow after experimental cardiac arrest cardiopulmonary resuscitation in pigs. , 2004, Resuscitation.

[21]  Simon C Watkins,et al.  Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway* , 2004, Journal of Biological Chemistry.

[22]  O. Hurtado,et al.  Role of nitric oxide after brain ischaemia. , 2004, Cell calcium.

[23]  Changlian Zhu,et al.  PARP‐1 gene disruption in mice preferentially protects males from perinatal brain injury , 2004, Journal of neurochemistry.

[24]  S. Basu,et al.  Differences in cerebral reperfusion and oxidative injury after cardiac arrest in pigs , 2003, Acta anaesthesiologica Scandinavica.

[25]  G. Kramer.  Hypertonic resuscitation: physiologic mechanisms and recommendations for trauma care. , 2003, The Journal of trauma.

[26]  A. Hoeft,et al.  Effects of hypertonic saline on myocardial blood flow in a porcine model of prolonged cardiac arrest. , 2002, Resuscitation.

[27]  P. Safar,et al.  Suspended animation for delayed resuscitation , 2002, Critical care medicine.

[28]  D. Partrick,et al.  A critical analysis of outcome for children sustaining cardiac arrest after blunt trauma. , 2002, Journal of pediatric surgery.

[29]  I. Chaudry,et al.  Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis. , 2001, Cytokine.

[30]  P. Chan.  Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[31]  J. G. van der Hoeven,et al.  Cerebral blood flow after cardiac arrest. , 2000, The Netherlands journal of medicine.

[32]  I. Chaudry,et al.  EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK , 2000, Shock.

[33]  P. Rhee,et al.  Survival after emergency department thoracotomy: review of published data from the past 25 years. , 2000, Journal of the American College of Surgeons.

[34]  S. Basu.  Radioimmunoassay of 15-keto-13,14-dihydro-prostaglandin F2alpha: an index for inflammation via cyclooxygenase catalysed lipid peroxidation. , 1998, Prostaglandins, leukotrienes, and essential fatty acids.

[35]  S. Basu.  Radioimmunoassay of 8-iso-prostaglandin F2alpha: an index for oxidative injury via free radical catalysed lipid peroxidation. , 1998, Prostaglandins, leukotrienes, and essential fatty acids.

[36]  J. Westman,et al.  Involvement of Nitric Oxide in the Pathophysiology of Acute Heat Stress in the Rat , 1997 .

[37]  R. Bellomo,et al.  Resuscitation from severe hemorrhage. , 1996, Critical care medicine.

[38]  A. Rosemurgy,et al.  Prehospital traumatic cardiac arrest: the cost of futility. , 1993, The Journal of trauma.

[39]  R. Koehler,et al.  Blood-brain barrier disruption after cardiopulmonary resuscitation in immature swine. , 1991, Stroke.

[40]  C. Wade,et al.  Normal physiological values for conscious pigs used in biomedical research. , 1990, Laboratory animal science.

[41]  S. H. Ralston,et al.  Fluid loading with whole blood or Ringer's lactate solution during CPR in dogs. , 1987, Resuscitation.

[42]  G. Burrows.  Methylene blue: effects and disposition in sheep. , 1984, Journal of veterinary pharmacology and therapeutics.

[43]  D. Fung,et al.  Dyed but not dead--methylene blue overdose. , 1976, Anesthesiology.

[44]  A. Hoeft,et al.  Hypertonic saline during CPR: Feasibility and safety of a new protocol of fluid management during resuscitation. , 2007, Resuscitation.

[45]  J. Westman,et al.  Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290/51. , 1997, Annals of the New York Academy of Sciences.

[46]  J. Cervós-Navarro,et al.  Brain oedema and cellular changes induced by acute heat stress in young rats. , 1990, Acta neurochirurgica. Supplementum.

[47]  M. Kelner,et al.  Potential of methylene blue to block oxygen radical generation in reperfusion injury. , 1988, Basic life sciences.