Experimental glucose regulation with a High-Order Sliding-Mode Controller

Theoretically High-Order Sliding-Mode Controllers are well suited to perform closed loop glucose regulation because they are insensitive to parameter uncertainties and robust to unknown dynamics that may perturb the system. The implementation of the controller based on the concept of practical relative degree is presented. The controller was tested in Sprague-Dawley rats with steptozotocin induced diabetes. The tests demonstrated high efficacy and robustness of the controller.

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