cirrhosis Hrd 1 suppresses Nrf 2-mediated cellular protection during liver Material Supplemental

Material Supplemental http://genesdev.cshlp.org/content/suppl/2014/03/11/gad.238246.114.DC1.html References http://genesdev.cshlp.org/content/28/7/708.full.html#ref-list-1 This article cites 49 articles, 25 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ at Creative Commons License (Attribution-NonCommercial 4.0 International), as described ). After six months, it is available under a http://genesdev.cshlp.org/site/misc/terms.xhtml six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first

[1]  Donna D. Zhang,et al.  The emerging role of the Nrf2–Keap1 signaling pathway in cancer , 2013, Genes & development.

[2]  H. Perlman,et al.  Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis , 2013, The EMBO journal.

[3]  Z. Lu,et al.  Alcohol Cirrhosis Alters Nuclear Receptor and Drug Transporter Expression in Human Liver , 2013, Drug Metabolism and Disposition.

[4]  X. Chen,et al.  Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice. , 2013, Toxicology and applied pharmacology.

[5]  Tie Wu,et al.  The Protective Effect of Glycyrrhetinic Acid on Carbon Tetrachloride-Induced Chronic Liver Fibrosis in Mice via Upregulation of Nrf2 , 2013, PloS one.

[6]  K. Zou,et al.  The Ubiquitin Ligase Synoviolin Up-regulates Amyloid β Production by Targeting a Negative Regulator of γ-Secretase, Rer1, for Degradation* , 2012, The Journal of Biological Chemistry.

[7]  Q. Ma,et al.  Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2 , 2012, Pharmacological Reviews.

[8]  S. Aratani,et al.  RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis , 2012, International journal of molecular medicine.

[9]  Shelly C. Lu,et al.  Mechanism and Significance of Changes in Glutamate-Cysteine Ligase Expression during Hepatic Fibrogenesis* , 2012, The Journal of Biological Chemistry.

[10]  A. Cuadrado,et al.  Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. , 2012, Oncogene.

[11]  P. Rada,et al.  Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis , 2012, Molecular and Cellular Biology.

[12]  M. Droździk,et al.  Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease. , 2012, Environmental toxicology and pharmacology.

[13]  Longqin Hu,et al.  Small Molecule Modulators of Keap1‐Nrf2‐ARE Pathway as Potential Preventive and Therapeutic Agents , 2012, Medicinal research reviews.

[14]  T. Wynn,et al.  Mechanisms of fibrosis: therapeutic translation for fibrotic disease , 2012, Nature Medicine.

[15]  R. Silverman,et al.  The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule , 2012, Proceedings of the National Academy of Sciences.

[16]  Hongting Zheng,et al.  Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy , 2011, Diabetes.

[17]  Masayuki Yamamoto,et al.  Dual Regulation of the Transcriptional Activity of Nrf1 by β-TrCP- and Hrd1-Dependent Degradation Mechanisms , 2011, Molecular and Cellular Biology.

[18]  S. Friedman,et al.  Pathogenesis of liver fibrosis. , 2011, Annual review of pathology.

[19]  P. Rada,et al.  SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner , 2011, Molecular and Cellular Biology.

[20]  S. Friedman,et al.  E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis , 2010, PloS one.

[21]  E. Krüger,et al.  Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. , 2010, Molecular cell.

[22]  D. Chan,et al.  In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences , 2010, Journal of Cell Science.

[23]  G. Sykiotis,et al.  Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease , 2010, Science Signaling.

[24]  N. Kawada,et al.  Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine–choline-deficient diet , 2010, Laboratory Investigation.

[25]  Donna D. Zhang,et al.  Nrf2 protects against As(III)-induced damage in mouse liver and bladder. , 2009, Toxicology and applied pharmacology.

[26]  Donna D. Zhang,et al.  Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. , 2009, Molecular cell.

[27]  Donna D. Zhang,et al.  Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response , 2009, Molecular and Cellular Biology.

[28]  R. Kaufman,et al.  Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. , 2008, Journal of biochemistry.

[29]  Donna D. Zhang,et al.  Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen‐induced arthritis , 2008, EMBO reports.

[30]  Donna D. Zhang,et al.  Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2 , 2007, Molecular and Cellular Biology.

[31]  S. Yamasaki,et al.  Cytoplasmic destruction of p53 by the endoplasmic reticulum‐resident ubiquitin ligase ‘Synoviolin’ , 2007, The EMBO journal.

[32]  A. Kong,et al.  Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. , 2007, Toxicology letters.

[33]  Shyam Biswal,et al.  Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. , 2007, Annual review of pharmacology and toxicology.

[34]  Masayuki Yamamoto,et al.  Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. , 2006, The Biochemical journal.

[35]  Akira Kobayashi,et al.  Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism , 2006, Biological chemistry.

[36]  K. Itoh,et al.  Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism , 2006, Journal of Biological Chemistry.

[37]  Tom A. Rapoport,et al.  Distinct Ubiquitin-Ligase Complexes Define Convergent Pathways for the Degradation of ER Proteins , 2006, Cell.

[38]  Sakae Tanaka,et al.  Essential Role of Synoviolin in Embryogenesis* , 2005, Journal of Biological Chemistry.

[39]  Mark Hannink,et al.  Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex , 2004, Molecular and Cellular Biology.

[40]  Masayuki Yamamoto,et al.  Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 , 2004, Molecular and Cellular Biology.

[41]  Mark Hannink,et al.  Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress , 2003, Molecular and Cellular Biology.

[42]  S. Yamasaki,et al.  Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. , 2003, Genes & development.

[43]  Stevan R. Hubbard,et al.  IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA , 2002, Nature.

[44]  K. Mori,et al.  XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor , 2001, Cell.

[45]  Peter Walter,et al.  Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation , 2000, Cell.

[46]  Ze Zheng,et al.  Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. , 2011, Methods in enzymology.

[47]  川田 一仁 Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis , 2010 .

[48]  A. Mallat,et al.  Hepatic fibrosis: molecular mechanisms and drug targets. , 2005, Annual review of pharmacology and toxicology.

[49]  J. D. Engel,et al.  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.