Global public health efforts to address HIV and related communicable disease

Global efforts to address the HIV/AIDS pandemic have been framed within a public health approach that aims to simplify and standardize treatment and care interventions to support delivery of treatment and care at scale [1]. Key approaches include the use of standardized treatment regimens and monitoring approaches, promote task sharing and community involvement, and implement simplified and integrated service delivery. Together these approaches support access to care across the health system and remove barriers to accessing care when relying on specialized staff and resources [2 && ]. The public health approach has enabled 24.5 million people to receive antiretroviral therapy (ART) as of mid-2019 (https:// www.unaids.org/en/resources/fact-sheet). People living with HIV (PLHIV) are at increased risk of acquiring illness from common comorbidities, such as tuberculosis (TB), viral hepatitis, sexually transmitted infections (STIs), as well as a range of opportunistic infections, because of either shared routes of transmission or increased susceptibility due to immunosuppression. Syndemics are defined as the aggregation of two or more epidemics in a population that interact to exacerbate the burden and prognosis of both diseases [3,4].

[1]  P. Easterbrook,et al.  Prevalence and burden of HBV co‐infection among people living with HIV: A global systematic review and meta‐analysis , 2019, Journal of viral hepatitis.

[2]  Maria H. Kim,et al.  Prioritising the most needed paediatric antiretroviral formulations: the PADO4 list. , 2019, The lancet. HIV.

[3]  M. Unemo,et al.  Diagnosing sexually transmitted infections in resource‐constrained settings: challenges and ways forward , 2019, Journal of the International AIDS Society.

[4]  S. Lockman,et al.  Neural-Tube Defects and Antiretroviral Treatment Regimens in Botswana. , 2019, The New England journal of medicine.

[5]  N. Ford,et al.  Optimizing responses to drug safety signals in pregnancy: the example of dolutegravir and neural tube defects , 2019, Journal of the International AIDS Society.

[6]  Monika Roy,et al.  A Review of Differentiated Service Delivery for HIV Treatment: Effectiveness, Mechanisms, Targeting, and Scale , 2019, Current HIV/AIDS Reports.

[7]  K. Dheda,et al.  What is new in the WHO consolidated guidelines on drug-resistant tuberculosis treatment? , 2019, The Indian journal of medical research.

[8]  D. Falzon,et al.  Towards all-oral and shorter treatment regimens for drug-resistant tuberculosis , 2018, Bulletin of the World Health Organization.

[9]  N. Ford,et al.  Sensitivity and specificity of WHO's recommended four-symptom screening rule for tuberculosis in people living with HIV: a systematic review and meta-analysis. , 2018, The lancet. HIV.

[10]  N. Ford,et al.  The transition to dolutegravir and other new antiretrovirals in low-income and middle-income countries: what are the issues? , 2018, AIDS.

[11]  R. Shapiro,et al.  Neural-Tube Defects with Dolutegravir Treatment from the Time of Conception. , 2018, The New England journal of medicine.

[12]  T. Klimkait,et al.  Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial , 2018, JAMA.

[13]  T. Le World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy , 2018 .

[14]  R. Peeling,et al.  Point-of-care tests for STIs: the way forward , 2017, Sexually Transmitted Infections.

[15]  N. Ford,et al.  The WHO public health approach to HIV treatment and care: looking back and looking ahead. , 2017, The Lancet. Infectious diseases.

[16]  N. Ford,et al.  When could new antiretrovirals be recommended for national treatment programmes in low-income and middle-income countries: results of a WHO Think Tank , 2017, Current opinion in HIV and AIDS.

[17]  N. Ford,et al.  The evolving role of CD4 cell counts in HIV care , 2017, Current opinion in HIV and AIDS.

[18]  P. Easterbrook,et al.  Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis. , 2016, The Lancet. Infectious diseases.

[19]  K. Looker,et al.  Impact of Opioid Substitution Therapy on Antiretroviral Therapy Outcomes: A Systematic Review and Meta-Analysis , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  N. Ford,et al.  Reimagining HIV service delivery: the role of differentiated care from prevention to suppression , 2016, Journal of the International AIDS Society.

[21]  G. Rutherford,et al.  Improving antiretroviral therapy scale-up and effectiveness through service integration and decentralization , 2014, AIDS.

[22]  N. Ford,et al.  Decentralising HIV treatment in lower- and middle-income countries , 2013, The Cochrane database of systematic reviews.

[23]  K. Venkatesh,et al.  Interactions of HIV, Other Sexually Transmitted Diseases, and Genital Tract Inflammation Facilitating Local Pathogen Transmission and Acquisition , 2011, American journal of reproductive immunology.

[24]  M. Singer,et al.  Generations of Suffering: Experiences of a Treatment Program for Substance Abuse During Pregnancy , 2010, Journal of health care for the poor and underserved.

[25]  S. Gove,et al.  The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings , 2006, The Lancet.

[26]  D. Fleming,et al.  From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. , 1999, Sexually transmitted infections.

[27]  A. Korobitsyn Lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis of active tuberculosis in people living with HIV , 2019 .

[28]  G. Indolfi Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection , 2018 .

[29]  Á. Száz Minimal structures , generalized topologies , and ascending systems should not be studied without generalized uniformities , 2007 .