Habituation and sensitization in rat auditory evoked potentials: a single-trial analysis with wavelet denoising

In this work, systematic changes of single-trial auditory evoked potentials elicited in rats were studied. Single-trial evoked potentials were obtained with the help of wavelet denoising, a very recently proposed method that has already been shown to be useful in the analysis of scalp human evoked potentials. For the evoked components in the 13-24-ms range (i.e. P13, N18, P20 and N24), it was possible to identify slow exponential decreases in the peak amplitudes, most likely related to a slow habituation process, while for N18, an initial increase in amplitude was also found. On the contrary, the slower components (N38 and N52) habituated within a few trials, and we therefore propose that they are related to a different functional process. The outcomes of the present study show that wavelet denoising is a useful technique for analyzing evoked potentials in rats at the single-trial level. In fact, in the present study it was possible to obtain more information than the one described in previous related works. This allows the study of other forms of learning processes in rats with the aid of evoked potentials. Finally, the outcomes of this study may have some relevance for the comparison of human and rat evoked potentials.

[1]  A. Grossmann,et al.  DECOMPOSITION OF HARDY FUNCTIONS INTO SQUARE INTEGRABLE WAVELETS OF CONSTANT SHAPE , 1984 .

[2]  O. Bertrand,et al.  Time-frequency digital filtering based on an invertible wavelet transform: an application to evoked potentials , 1994, IEEE Transactions on Biomedical Engineering.

[3]  E. Garcia-Rill,et al.  Midlatency auditory evoked potentials and the startle response in the rat , 1996, Neuroscience.

[4]  J. Ali,et al.  Within-session changes in peak N160 amplitude of flash evoked potentials in rats , 1994, Physiology & Behavior.

[5]  N. Boutros,et al.  A Parametric Study of the N40 Auditory Evoked Response in Rats , 1997, Biological Psychiatry.

[6]  Ernst Fernando Lopes Da Silva Niedermeyer,et al.  Electroencephalography, basic principles, clinical applications, and related fields , 1982 .

[7]  M. Molnár,et al.  On the origin of the P3 event-related potential component. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[8]  R. F. Thompson,et al.  Habituation: a model phenomenon for the study of neuronal substrates of behavior. , 1966, Psychological review.

[9]  A. Coenen,et al.  Two types of electrocortical paroxysms in an inbred strain of rats , 1986, Neuroscience Letters.

[10]  E. Ba§ar,et al.  EEG-Brain dynamics: Relation between EEG and brain evoked potentials , 1982 .

[11]  W. Ritter,et al.  Orienting and habituation to auditory stimuli: a study of short term changes in average evoked responses. , 1968, Electroencephalography and clinical neurophysiology.

[12]  H. Fruhstorfer,et al.  Short-term habituation of the auditory evoked response in man. , 1970, Electroencephalography and clinical neurophysiology.

[13]  A. Cools,et al.  Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats , 1999, Psychopharmacology.

[14]  S. T. Buckland,et al.  An Introduction to the Bootstrap. , 1994 .

[15]  T W Picton,et al.  The P300 Wave of the Human Event‐Related Potential , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[16]  Gavin S. Lew,et al.  P300, habituation, and response mode , 1993, Physiology & Behavior.

[17]  Enoch Callaway,et al.  Habituation of Averaged Evoked Potentials in Man , 1973 .

[18]  E. Garcia-Rill,et al.  Midlatency auditory-evoked potentials in the rat: effects of interventions that modulate arousal , 1999, Brain Research Bulletin.

[19]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[20]  Charles K. Chui,et al.  An Introduction to Wavelets , 1992 .

[21]  R D Hall,et al.  Habituation of evoked potentials in the rat under conditions of behavioral control. , 1968, Electroencephalography and clinical neurophysiology.

[22]  E. Garcia-Rill,et al.  A middle-latency auditory-evoked potential in the rat , 1995, Brain Research Bulletin.

[23]  M Schürmann,et al.  Functions and sources of event-related EEG alpha oscillations studied with the Wavelet Transform , 1999, Clinical Neurophysiology.

[24]  L. Garcia-Larrea,et al.  On the validity of interblock averaging of P300 in clinical settings. , 1999, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[25]  V. Samar,et al.  Multiresolution Analysis of Event-Related Potentials by Wavelet Decomposition , 1995, Brain and Cognition.

[26]  I. Daubechies,et al.  Biorthogonal bases of compactly supported wavelets , 1992 .

[27]  H. Davis,et al.  The slow response of the human cortex to auditory stimuli: recovery process. , 1966, Electroencephalography and clinical neurophysiology.

[28]  J. Polich,et al.  Comparison of auditory P300 habituation from active and passive conditions. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[29]  J. Polich.  Habituation of P300 from auditory stimuli , 1989, Psychobiology.

[30]  Michael Unser,et al.  On the asymptotic convergence of B-spline wavelets to Gabor functions , 1992, IEEE Trans. Inf. Theory.

[31]  A. Coenen.  Neuronal activities underlying the electroencephalogram and evoked potentials of sleeping and waking: Implications for information processing , 1995, Neuroscience & Biobehavioral Reviews.

[32]  M Unser,et al.  Fast wavelet transformation of EEG. , 1994, Electroencephalography and clinical neurophysiology.

[33]  M. Kutas,et al.  Localizing the Neural Generators of Event-Related Brain Potentials , 2002 .

[34]  I. Daubechies.  Orthonormal bases of compactly supported wavelets , 1988 .

[35]  Michael Unser,et al.  A review of wavelets in biomedical applications , 1996, Proc. IEEE.

[36]  A. Belger,et al.  Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating , 1999, Biological Psychiatry.

[37]  Andrew Kertesz,et al.  Localization and neuroimaging in neuropsychology , 1994 .

[38]  A. Cools,et al.  Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval , 2001, Biological Psychology.

[39]  P. Badia,et al.  Habituation of P300 to target stimuli , 1989, Physiology & Behavior.

[40]  Stéphane Mallat,et al.  A Theory for Multiresolution Signal Decomposition: The Wavelet Representation , 1989, IEEE Trans. Pattern Anal. Mach. Intell..

[41]  P. Groves,et al.  Habituation: a dual-process theory. , 1970, Psychological review.

[42]  R.Quian Quiroga,et al.  Obtaining single stimulus evoked potentials with wavelet denoising , 2000, nlin/0006027.

[43]  F. H. Lopes da Silva,et al.  Event-related potentials: methodology and quantification , 1998 .

[44]  E Gordon,et al.  Does the N100 evoked potential really habituate? Evidence from a paradigm appropriate to a clinical setting. , 1992, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.