Surface size, curvature analysis, and assessment of knee joint incongruity with MRI in vivo

The purpose of this study was to develop an MR‐based technique for quantitative analysis of joint surface size, surface curvature, and joint incongruity and to assess its reproducibility under in vivo imaging conditions. The surface areas were determined after 3D reconstruction of the joint by triangulation and the incongruity by Gaussian curvature analysis. The precision was tested by analyzing four replicated MRI datasets of human knees in 14 individuals. The algorithms were shown to produce accurate data in geometric test objects. The interscan precision was <4% (CV%) for surface area, 2.9–5.7 m−1 (SD) for the mean principal curvature, and 4.1–7.4 m−1 for congruence indices. Incongruity was highest in the femoropatellar joint (79.7 m−1) and lowest in the medial femorotibial joint (28.6 m−1). This technique will permit identification of the specific role of surface size, curvature, and incongruity as potential risk factors for osteoarthritis. Magn Reson Med 47:554–561, 2002. © 2002 Wiley‐Liss, Inc.

[1]  G. Ateshian.  A B-spline least-squares surface-fitting method for articular surfaces of diarthrodial joints. , 1993, Journal of biomechanical engineering.

[2]  V C Mow,et al.  Quantitation of articular surface topography and cartilage thickness in knee joints using stereophotogrammetry. , 1991, Journal of biomechanics.

[3]  T Stammberger,et al.  Interobserver reproducibility of quantitative cartilage measurements: comparison of B-spline snakes and manual segmentation. , 1999, Magnetic resonance imaging.

[4]  F. Cicuttini,et al.  Sex and site differences in cartilage development: a possible explanation for variations in knee osteoarthritis in later life. , 2000, Arthritis and rheumatism.

[5]  L. Sokoloff.  The Biology of Degenerative Joint Disease , 2015, Perspectives in biology and medicine.

[6]  Maximilian Reiser,et al.  Quantitative relationships of normal cartilage volumes of the human knee joint – assessment by magnetic resonance imaging , 1998, Anatomy and Embryology.

[7]  Leena Sharma,et al.  Varus-valgus alignment in the progression of knee OA , 2001 .

[8]  M. Reiser,et al.  Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging , 2001, Skeletal Radiology.

[9]  D. Felson,et al.  The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. , 1995, Arthritis and rheumatism.

[10]  T Stammberger,et al.  Optimization and validation of a rapid high-resolution T1-w 3D FLASH water excitation MRI sequence for the quantitative assessment of articular cartilage volume and thickness. , 2001, Magnetic resonance imaging.

[11]  F Eckstein,et al.  The distribution of cartilage thickness within the joints of the lower limb of elderly individuals , 1998, Journal of anatomy.

[12]  P. Wolf,et al.  The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. , 1994, American journal of public health.

[13]  T. Brown,et al.  Mechanical determinants of osteoarthrosis. , 1991, Seminars in arthritis and rheumatism.

[14]  P. Bullough,et al.  The morphology of the calcification front in articular cartilage. Its significance in joint function. , 1983, The Journal of bone and joint surgery. British volume.

[15]  L. Sharma,et al.  Laxity in healthy and osteoarthritic knees. , 1999, Arthritis and rheumatism.

[16]  J. O'Connor,et al.  Incongruent Surfaces in the Human Hip Joint , 1968, Nature.

[17]  V. Mow,et al.  Curvature characteristics and congruence of the thumb carpometacarpal joint: differences between female and male joints. , 1992, Journal of biomechanics.

[18]  Walter Herzog,et al.  An improved solution for the contact of two biphasic cartilage layers , 1997 .

[19]  T Stammberger,et al.  Validation of high-resolution water-excitation magnetic resonance imaging for quantitative assessment of thin cartilage layers. , 2000, Osteoarthritis and cartilage.

[20]  T D Brown,et al.  Chronic stress tolerance levels for human articular cartilage: two nonuniform contact models applied to long-term follow-up of CDH. , 1995, Journal of biomechanics.

[21]  W M Lai,et al.  An asymptotic solution for the contact of two biphasic cartilage layers. , 1994, Journal of biomechanics.

[22]  Kuo-Liang Chung,et al.  Parallel B-Spline Surface Fitting on Mesh-Connected Computers , 1996, J. Parallel Distributed Comput..

[23]  J. Arokoski,et al.  Effect of motion and load on articular cartilage in animal models , 1992 .

[24]  P. Bullough,et al.  The geometry of diarthrodial joints, its physiologic maintenance, and the possible significance of age-related changes in geometry-to-load distribution and the development of osteoarthritis. , 1981, Clinical orthopaedics and related research.

[25]  F. Cicuttini,et al.  Gender differences in knee cartilage volume as measured by magnetic resonance imaging. , 1999, Osteoarthritis and cartilage.

[26]  H. Dorfman,et al.  Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. , 1971, The Journal of bone and joint surgery. American volume.

[27]  T. Stammberger,et al.  Determination of 3D cartilage thickness data from MR imaging: Computational method and reproducibility in the living , 1999, Magnetic resonance in medicine.

[28]  Maximilian Reiser,et al.  In vivo morphometry and functional analysis of human articular cartilage with quantitative magnetic resonance imaging – from image to data, from data to theory , 2001, Anatomy and Embryology.

[29]  D. Felson,et al.  Epidemiology of hip and knee osteoarthritis. , 1988, Epidemiologic reviews.

[30]  M. F. Reiser,et al.  Geschlechtsspezifische Analyse der Knorpelvolumina des Kniegelenks — eine quantitative MRT-basierte Studie , 1998 .

[31]  V C Mow,et al.  Anatomy of the human patellofemoral joint articular cartilage: Surface curvature analysis , 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[32]  Z A C,et al.  Knee cartilage topography , thickness , and contact areas from MRI : in-vitro calibration and in-vivo measurements , 1999 .

[33]  H. Mankin,et al.  The response of articular cartilage to mechanical injury. , 1982, The Journal of bone and joint surgery. American volume.

[34]  E Hierholzer,et al.  Stress on the articular surface of the hip joint in healthy adults and persons with idiopathic osteoarthrosis of the hip joint. , 1981, Journal of biomechanics.

[35]  D W Piraino,et al.  Fat suppressed MRI of articular cartilage with a spatial‐spectral excitation pulse , 1998, Journal of magnetic resonance imaging : JMRI.

[36]  R Burgkart,et al.  Magnetic resonance imaging-based assessment of cartilage loss in severe osteoarthritis: accuracy, precision, and diagnostic value. , 2001, Arthritis and rheumatism.

[37]  C C Glüer,et al.  Quantification of articular cartilage in the knee with pulsed saturation transfer subtraction and fat-suppressed MR imaging: optimization and validation. , 1994, Radiology.