A Novel Method for Detection and Progress Assessment of Visual Distortion Caused by Macular Disorder: A Central Serous Chorioretinopathy (CSR) Case Study

This paper presents a new mathematical model along with a measurement platform for accurate detection and monitoring of various visual distortions (VD) caused by macular disorders such as central serous chorioretinopathy (CSR) and age-related macular degeneration (AMD). This platform projects a series of graphical patterns on the patient’s retina and calculates the severity of VDs accordingly. The accuracy of this technique relies on the accurate detection of distorted lines by the patient. We also propose a simple mathematical model to evaluate the VD created by CSR. The model is used as a control for the test results achieved from the proposed platform. The proposed platform consists of the required hardware and software for the generation and projection of patterns along with the collection and processing of patients against their standard optical coherence tomography (OCT) images. Based on these results, the OCT images agree with the VD test results, and the proposed platform can be used as an alternative home monitoring method for various macular disorders.

[1]  M. Ávila,et al.  Comparison of the original Amsler grid with the preferential hyperacuity perimeter for detecting choroidal neovascularization in age-related macular degeneration. , 2007, Arquivos brasileiros de oftalmologia.

[2]  R A Schuchard,et al.  Validity and interpretation of Amsler grid reports. , 1993, Archives of ophthalmology.

[3]  F. Wen,et al.  Poor Sleep Quality Is the Risk Factor for Central Serous Chorioretinopathy , 2018, Journal of ophthalmology.

[4]  Yu Tian,et al.  Design and Development of a Medical Big Data Processing System Based on Hadoop , 2015, Journal of Medical Systems.

[5]  P. Knox,et al.  Assessment of visual distortions in age-related macular degeneration: emergence of new approaches. , 2015, The British and Irish orthoptic journal.

[6]  P. Fitts The information capacity of the human motor system in controlling the amplitude of movement. , 1954, Journal of experimental psychology.

[7]  A. Grzybowski,et al.  M-charts as a tool for quantifying metamorphopsia in age-related macular degeneration treated with the bevacizumab injections , 2013, BMC Ophthalmology.

[8]  Yanchun Zhang,et al.  Medical Big Data: Neurological Diseases Diagnosis Through Medical Data Analysis , 2016, Data Science and Engineering.

[9]  Gary Rubin,et al.  The Amsler chart: absence of evidence is not evidence of absence , 2007, British Journal of Ophthalmology.

[10]  A. Loewenstein,et al.  Results of a Multicentered, Masked Clinical Trial to Evaluate the Macular Computerized Psychophysical Test (MCPT) for Detection of Age-related Macular Degeneration (AMD) , 2002 .

[11]  Navid Mohaghegh,et al.  Age-Related Macular Degeneration Diagnostic Tools: Hardware and Software Development , 2018, 2018 IEEE 61st International Midwest Symposium on Circuits and Systems (MWSCAS).

[12]  Benita J. O’Colmain,et al.  Prevalence of age-related macular degeneration in the United States. , 2004, Archives of ophthalmology.

[13]  Joseph C. Besharse,et al.  The retina and its disorders , 2011 .

[14]  Frcs,et al.  Central Serous Chorioretinopathy , 2012 .

[15]  M AMSLER,et al.  Earliest Symptoms of Diseases of the Macula *† , 1953, The British journal of ophthalmology.

[16]  P. Jong Prevalence of age-related macular degeneration in the United States. , 2004 .

[17]  R. Trevino Recent progress in macular function self‐assessment , 2008, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[18]  V. Lakshminarayanan,et al.  Vernier acuity and aging , 2004, International Ophthalmology.

[19]  J. Kaas,et al.  Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina. , 1990, Science.

[20]  A. Meduri,et al.  Fixation stability measurements in patients with neovascular age-related macular degeneration treated with ranibizumab. , 2013, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[21]  Jennifer K. Sun,et al.  CENTRAL SEROUS CHORIORETINOPATHY ASSOCIATED WITH STEROID ENEMA. , 2018, Retinal cases & brief reports.

[22]  Amitha Domalpally,et al.  Randomized trial of a home monitoring system for early detection of choroidal neovascularization home monitoring of the Eye (HOME) study. , 2014, Ophthalmology.

[23]  Wolfgang Fink,et al.  Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing , 2011, British Journal of Ophthalmology.

[24]  Joongheon Kim,et al.  Stochastic Decision Making for Adaptive Crowdsourcing in Medical Big-Data Platforms , 2015, IEEE Transactions on Systems, Man, and Cybernetics: Systems.