A theoretical investigation of chirp insonification of ultrasound contrast agents.

A theoretical investigation of second harmonic imaging of an Ultrasound Contrast Agent (UCA) under chirp insonification is considered. By solving the UCA's dynamical equation analytically, the effect that the chirp signal parameters and the UCA shell parameters have on the amplitude of the second harmonic frequency are examined. This allows optimal parameter values to be identified which maximise the UCA's second harmonic response. A relationship is found for the chirp parameters which ensures that a signal can be designed to resonate a UCA for a given set of shell parameters. It is also shown that the shell thickness, shell viscosity and shell elasticity parameter should be as small as realistically possible in order to maximise the second harmonic amplitude. Keller-Herring, Second Harmonic, Chirp, Ultrasound Contrast Agent.

[1]  Detlef Lohse,et al.  A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture , 2005 .

[2]  Meng-Xing Tang,et al.  Physical Phenomena Affecting Quantitative Imaging of Ultrasound Contrast Agent , 2009 .

[3]  E. Unger,et al.  Therapeutic applications of microbubbles , 2001 .

[4]  Georg Schmitz,et al.  Phospholipid-stabilized microbubbles: Influence of shell chemistry on cavitation threshold and binding to giant uni-lamellar vesicles , 2009 .

[5]  T. Leighton.  The Acoustic Bubble , 1994 .

[6]  Ronald A. Roy,et al.  Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material. , 2001, Ultrasound in medicine & biology.

[7]  P. Dayton,et al.  Experimental and theoretical evaluation of microbubble behavior: effect of transmitted phase and bubble size , 2000, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[8]  P. Tortoli,et al.  Method for Microbubble Characterization Using Primary Radiation Force , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[9]  P. Dayton,et al.  High-frequency dynamics of ultrasound contrast agents , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[10]  A. Bouakaz,et al.  The resonance frequency of SonoVue/spl trade/ as observed by high-speed optical imaging , 2004, IEEE Ultrasonics Symposium, 2004.

[11]  A. Bouakaz,et al.  Harmonic chirp imaging method for ultrasound contrast agent , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[12]  N. Bom,et al.  Noninvasive measurement of the hydrostatic pressure in a fluid-filled cavity based on the disappearance time of micrometer-sized free gas bubbles. , 1999, Ultrasound in medicine & biology.

[13]  Junru Wu,et al.  Ultrasound-induced cell lysis and sonoporation enhanced by contrast agents. , 1999, The Journal of the Acoustical Society of America.

[14]  Yang Sun,et al.  Contrast imaging with chirped excitation , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[15]  Georg Schmitz,et al.  Discussion of the application of finite Volterra series for the modeling of the oscillation behavior of ultrasound contrast agents , 2009 .

[16]  E Stride,et al.  The influence of surface adsorption on microbubble dynamics , 2008, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[17]  Hairong Zheng,et al.  Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique , 2007, Physics in medicine and biology.

[18]  S. L. Bridal,et al.  Double passive cavitation detection of Optison shell rupture , 2005, IEEE Ultrasonics Symposium, 2005..

[19]  Georg Schmitz,et al.  Ultrasonic bubbles in medicine: influence of the shell. , 2007, Ultrasonics sonochemistry.

[20]  Vassilis Sboros,et al.  A numerical investigation of the resonance of gas-filled microbubbles: resonance dependence on acoustic pressure amplitude. , 2004, Ultrasonics.

[21]  M. Wan,et al.  Optimal design and experimental investigation of surfactant encapsulated microbubbles. , 2006, Ultrasonics.

[22]  Jørgen Arendt Jensen,et al.  Ultrasound imaging using coded signals , 2001 .

[23]  Junru Wu,et al.  Experimental comparison of sonoporation and electroporation in cell transfection applications , 2004 .

[24]  Andrea Prosperetti,et al.  Bubble dynamics in a compressible liquid. Part 1. First-order theory , 1986, Journal of Fluid Mechanics.

[25]  Nico de Jong,et al.  Experimental evaluation of a non-linear coded excitation method for contrast imaging. , 2004, Ultrasonics.

[26]  A. Bouakaz,et al.  New contrast imaging method using double frequency exposure , 2004, IEEE Ultrasonics Symposium, 2004.

[27]  Charles T. Lancée,et al.  Higher harmonics of vibrating gas-filled microspheres. Part one: simulations , 1994 .

[28]  A. Nordon,et al.  Analysis of the Rayleigh-Plesset equation with chirp excitation , 2008 .

[29]  P. Dayton,et al.  Observation of contrast agent response to chirp insonation with a simultaneous optical-acoustical system , 2006, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[30]  Charles C. Church,et al.  The effects of an elastic solid surface layer on the radial pulsations of gas bubbles , 1995 .