DDK promotes DNA replication initiation: Mechanistic and structural insights.
暂无分享,去创建一个
N. Gao | Ningning Li | Y. Zhai
[1] J. Diffley,et al. Mechanism of replication origin melting nucleated by CMG helicase assembly , 2022, Nature.
[2] J. Blow,et al. DDK: The Outsourced Kinase of Chromosome Maintenance , 2022, Biology.
[3] Marcin J. Skwark,et al. The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer , 2022, Nature Communications.
[4] S. Gygi,et al. CDC7-independent G1/S transition revealed by targeted protein degradation , 2022, Nature.
[5] B. Tye,et al. Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase , 2022, Nature Communications.
[6] J. Seebacher,et al. A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6 , 2022, Nature communications.
[7] J. Diffley,et al. The Initiation of Eukaryotic DNA Replication. , 2022, Annual review of biochemistry.
[8] B. Stillman. The remarkable gymnastics of ORC , 2022, eLife.
[9] J. Diffley,et al. Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase , 2021, Nature Structural & Molecular Biology.
[10] Joseph T. P. Yeeles,et al. Structure of a human replisome shows the organisation and interactions of a DNA replication machine , 2021, The EMBO journal.
[11] S. Bell,et al. A helicase-tethered ORC flip enables bidirectional helicase loading , 2021, bioRxiv.
[12] D. Barford,et al. Structural basis of human separase regulation by securin and CDK1–cyclin B1 , 2021, Nature.
[13] B. Stillman,et al. The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6 , 2021, Nature Communications.
[14] M. Botchan,et al. Structural Mechanisms for Replicating DNA in Eukaryotes. , 2021, Annual review of biochemistry.
[15] M. O’Donnell,et al. The DNA Replication Machine: Structure and Dynamic Function. , 2021, Sub-cellular biochemistry.
[16] B. Stillman,et al. Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6 , 2020, Proceedings of the National Academy of Sciences.
[17] V. E. Pye,et al. Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase , 2020, Structure.
[18] D. Remus,et al. Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53 , 2020, bioRxiv.
[19] G. Cannone,et al. Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork , 2019, bioRxiv.
[20] J. Diffley,et al. Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM , 2019, Nature.
[21] B. Tye,et al. Structure of the origin recognition complex bound to DNA replication origin , 2018, Nature.
[22] J. Diffley,et al. Cryo-EM structure of a licensed DNA replication origin , 2017, Nature Communications.
[23] Changhui Yan,et al. Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing , 2017, Genes & development.
[24] B. Stillman,et al. Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model , 2017, Proceedings of the National Academy of Sciences.
[25] A. Bhutkar,et al. DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways , 2017, Neoplasia.
[26] Hao Wu,et al. Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer , 2017, Nature Structural &Molecular Biology.
[27] B. Stillman,et al. Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 , 2017, Nature Structural &Molecular Biology.
[28] M. O’Donnell,et al. Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation , 2017, Proceedings of the National Academy of Sciences.
[29] R. Ghirlando,et al. ‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7 , 2016, Scientific Reports.
[30] S. Bell,et al. Chromosome Duplication in Saccharomyces cerevisiae , 2016, Genetics.
[31] J. Diffley,et al. Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation , 2016, The EMBO journal.
[32] B. Tye,et al. Structure of the eukaryotic MCM complex at 3.8 Å , 2015, Nature.
[33] David Shore,et al. Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7. , 2014, Cell reports.
[34] Anoushka Davé,et al. Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity , 2014, Cell reports.
[35] M. Raghuraman,et al. Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex , 2014, Genes & development.
[36] Seiji Tanaka,et al. Helicase activation and establishment of replication forks at chromosomal origins of replication. , 2013, Cold Spring Harbor perspectives in biology.
[37] S. Matthews,et al. Crystal structure of human CDC7 kinase in complex with its activator DBF4 , 2012, Nature Structural &Molecular Biology.
[38] L. Johnson,et al. The structural basis for control of eukaryotic protein kinases. , 2012, Annual review of biochemistry.
[39] A. Guarné,et al. Saccharomyces cerevisiae Dbf4 Has Unique Fold Necessary for Interaction with Rad53 Kinase* , 2011, The Journal of Biological Chemistry.
[40] C. Brandl,et al. A Synthetic Human Kinase Can Control Cell Cycle Progression in Budding Yeast , 2011, G3: Genes | Genomes | Genetics.
[41] David P. Toczyski,et al. Damage-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing , 2010, Nature.
[42] J. Diffley,et al. Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation , 2010, Nature.
[43] Bruce Stillman,et al. The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 , 2009, Nature.
[44] S. Bell,et al. Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation. , 2009, Genes & development.
[45] H. Masai,et al. Cdc7 as a potential new target for cancer therapy. , 2008, Drug news & perspectives.
[46] Charlotta Lindvall,et al. Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation. , 2008, Neoplasia.
[47] K. Arai,et al. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7‐ASK kinase complex , 2003, Genes to cells : devoted to molecular & cellular mechanisms.
[48] P. Pahl,et al. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[49] A. Jackson,et al. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein , 1993, Molecular and cellular biology.
[50] H. Yoon,et al. Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. , 1993, Molecular biology of the cell.