Halothane macrophage migration inhibition factor test in halothane-associated hepatitis Halothane macrophage migration inhibition factor test in halothane-associated hepatitis Halothane macrophage migration inhibition factor test in halothane-associated hepatitis

SUMMARY As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis. Twenty-two subjects exposed to halothane, but with no evidence of jaundice, five 'healthy' hospital anaesthetists, nine jaundiced subjects without halothane exposure, and 10 healthy subjects with no history of exposure to halothane were also tested. The halothane-MIF test was positive in four of the five patients with halothane-induced hepatitis; the negative result was in a patient on steroid treatment. The test was negative in all other subjects. Our findings suggest that the halothane-MIF test may be of value in the diagnosis of halothane-induced hepatitis and as a screening procedure for the identification of susceptible subjects.

[1]  C. Kneepkens,et al.  [Recurrent hepatitis A]. , 1989, Tijdschrift voor kindergeneeskunde.

[2]  C. D. Price,et al.  Role of in vitro and in vivo tests of hypersensitivity in beryllium workers. , 1977, Journal of clinical pathology.

[3]  F. C. Shelley,et al.  Pathological parasites in food handlers , 1976, British medical journal.

[4]  R. Peto,et al.  CONTROLLED TRIAL OF REPEATED HALOTHANE ANAESTHETICS IN PATIENTS WITH CARCINOMA OF THE UTERINE CERVIX TREATED WITH RADIUM , 1975 .

[5]  O. Eade,et al.  CONTROLLED PROSPECTIVE STUDY OF THE EFFECT ON LIVER FUNCTION OF MULTIPLE EXPOSURES TO HALOTHANE , 1975, The Lancet.

[6]  W. Inman,et al.  Jaundice after Repeated Exposure to Halothane: An Analysis of Reports to the Committee on Safety of Medicines , 1974, British medical journal.

[7]  L. Strunin,et al.  Lymphocyte transformation. Absence of increased responses in alleged halothane jaundice. , 1973, JAMA.

[8]  B. Simpson,et al.  M.I.F. test in halothane jaundice. , 1972, British medical journal.

[9]  Williams Wj,et al.  The Kmif (Kveim-induced macrophage migration inhibition factor) test in sarcoidosis , 1972, Journal of clinical pathology.

[10]  E. V. Jones,et al.  Post-halothane Jaundice in Relation to Previous Administration of Halothane , 1971, British medical journal.

[11]  P. Sharpstone,et al.  Halothane Hepatitis—A Preventable Disease? , 1971, British medical journal.

[12]  F. Klion,et al.  Hepatitis after exposure to halothane. , 1971, Annals of internal medicine.

[13]  H. Popper,et al.  Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane. , 1970, The New England journal of medicine.

[14]  L. Powell,et al.  Recurrent hepatitis in patients receiving multiple halothane anesthetics for radium treatment of carcinoma of the cervix uteri. , 1970, Gastroenterology.

[15]  G. Klatskin,et al.  Recurrent hepatitis attributable to halothane sensitization in an anesthetist. , 1969, The New England journal of medicine.

[16]  M. H. Dykes,et al.  Postoperative Hepatic Necrosis. , 1964, Journal of the American Dental Society of Anesthesiology.

[17]  J. Lindenbaum,et al.  HEPATIC NECROSIS ASSOCIATED WITH HALOTHANE ANESTHESIA , 1963, The New England journal of medicine.

[18]  L. Vandam,et al.  ANESTHETIC, CIRCULATORY AND RESPIRATORY EFFECTS OF FLUOTHANE , 1958, Anesthesiology.

[19]  S. Sherlock,et al.  HALOTHANE-RELATED HEPATITIS , 1975 .

[20]  B. Bloom,et al.  1 – THE ASSAY OF INHIBITION OF MACROPHAGE MIGRATION AND THE PRODUCTION OF MIGRATION INHIBITORY FACTOR (MIF) AND SKIN REACTIVE FACTOR (SRF) IN THE GUINEA PIG* , 1971 .

[21]  POSTOPERATIVE death after fluothane. , 1958, Anesthesiology.