Vertebral spinal osteophytes

Osteoarthritis is a common complication in the elderly and is often associated with osteophyte growth on vertebral bodies. The clinical presentation of vertebral osteophytes is related to anatomical structures adjacent to the spinal column. For instance, cervical osteophytes potentially involve the pharynx and esophagus, leading to dysphagic symptoms that may be accompanied by food aspiration, vocal fold paralysis and obstructive sleep apnea. In addition to anterior cervical osteophytes, posterior and uncinate process osteophytes may form, compressing the spinal cord and vertebral artery blood supply, respectively. Cervical osteophytes have also been shown to form an accessory median atlanto-occipital joint when the relationship between the atlas, dens and basiocciput is involved. In the thorax, the esophagus is often affected by osteophytes and may result in dysphagia. Traumatic and non-traumatic thoracic aorta pseudoaneurysm formation has been attributed to sharp osteophytes lacerating the aorta, a direct complication of the relationship between the aorta anterior vertebral column. Additionally, aspiration pneumonia was reported in patients with compression of a main stem bronchus, due to mechanical compression by thoracic osteophytes. In the lumbar spinal region, the two major structures in close proximity to the spine are the inferior vena cava and abdominal aorta, both of which have been reported to be affected by osteophytes. Treatment of osteophytes is initially conservative with anti-inflammatory medications, followed by surgical removal. Increasing obesity and geriatric populations will continue to result in an array of osteoarthritic degenerative changes such as osteophyte formation.

[1]  M. Kanbay,et al.  DYSPHAGIA CAUSED BY CERVICAL OSTEOPHYTES: A RARE CASE , 2006, Journal of the American Geriatrics Society.

[2]  A. Seawright,et al.  Hypervitaminosis A and Hyperostosis of the Cat , 1965, Nature.

[3]  L. Riley,et al.  The results of anterior interbody fusion of the cervical spine. Review of ninety-three consecutive cases. , 1962, Journal of neurosurgery.

[4]  C. Coutelle,et al.  Lehrbuch der speziellen Pathologie , 1966 .

[5]  T. Sand,et al.  Neck Pain in the General Population , 1994, Spine.

[6]  Masashi Takahashi,et al.  Focal pulmonary interstitial opacities adjacent to thoracic spine osteophytes. , 2002, AJR. American journal of roentgenology.

[7]  N. Altinors,et al.  Dysphagia due to diffuse idiopathic skeletal hyperostosis , 2005, Acta Neurochirurgica.

[8]  D. Resnick Diffuse Idiopathic Skeletal Hyperostosis (DISH). , 1976, The Western journal of medicine.

[9]  Jr. Joseph Di Vito Cervical osteophytic dysphagia: single and combined mechanisms , 1998 .

[10]  M. Urist,et al.  Solubilized bone morphogenetic protein (BMP) from mouse osteosarcoma and rat demineralized bone matrix. , 1980, Clinical orthopaedics and related research.

[11]  Rosen Hj Dysphagia due to cervical spine osteophytes , 1985 .

[12]  D. Stuart Dysphagia due to cervical osteophytes , 1989, International Orthopaedics.

[13]  S. J. Brady,et al.  Dysphagia associated with lower thoracic spondylosis. , 2003, Rheumatology.

[14]  G. Ardran,et al.  Dysphagia due to cervical spondylosis , 1985, The Journal of Laryngology & Otology.

[15]  A. Wheatley,et al.  Transpharyngeal approach for the treatment of dysphagia due to Forestier's disease , 1999, The Journal of Laryngology & Otology.

[16]  L. Leibrock,et al.  Dysphagia and dysphonia secondary to anterior cervical osteophytes. , 1986, Neurosurgery.

[17]  Paul Clopton,et al.  Intervertebral disk calcification of the spine in an elderly population: radiographic prevalence, location, and distribution and correlation with spinal degeneration. , 2004, Radiology.

[18]  T. Jonung,et al.  Pseudoaneurysm of the abdominal aorta due to a needle-like osteophyte on the first lumbar vertebra. , 2007, Journal of vascular surgery.

[19]  M. Mafee,et al.  Dysphagia and Forestier's disease. , 1985, Archives of otolaryngology.

[20]  A. Prescher,et al.  The Median Atlanto-Occipital Joint in Advanced Age , 2006, Spine.

[21]  N. Rigual,et al.  Anterolateral Extrapharyngeal Approach for Cervical Osteophyte-Induced Dysphagia , 1984, The Annals of otology, rhinology, and laryngology.

[22]  P. Aronowitz,et al.  Anterior Cervical Osteophytes Causing Airway Compromise , 2003 .

[23]  J A León,et al.  Chronic obstructive pneumonia caused by a vertebral body osteophyte. , 2000, Mayo Clinic proceedings.

[24]  T. El Gammal,et al.  Thoracic osteophyte producing dysphagia in a case of diffuse idiopathic skeletal hypertrophy. , 1983, The American journal of gastroenterology.

[25]  D. Lucy,et al.  Comparative degenerative joint disease of the vertebral column in the medieval monastic cemetery of the Gilbertine priory of St. Andrew, Fishergate, York, England. , 1997, American journal of physical anthropology.

[26]  D. Denk,et al.  Cervical osteophytes impinging on the pharynx: importance of size and concurrent disorders for development of aspiration. , 2000, AJR. American journal of roentgenology.

[27]  P. Srinivas,et al.  Cervical osteoarthropathy: an unusual cause of dysphagia. , 1999, Age and ageing.

[28]  L. Riley,et al.  Cervical migraine. Not merely a pain in the neck. , 1969, The American journal of medicine.

[29]  H. Nathan Osteophytes of the Spine Compressing the Sympathetic Trunk and Splanchnic Nerves in the Thorax , 1987, Spine.

[30]  J. Edmeads Headaches and head pains associated with diseases of the cervical spine. , 1978, The Medical clinics of North America.

[31]  P. S. Bridges Vertebral arthritis and physical activities in the prehistoric southeastern United States. , 1994, American journal of physical anthropology.

[32]  M. Sage,et al.  Cervical osteophyte induced dysphagia. , 1989, Australasian radiology.

[33]  J. Balla,et al.  VERTEBRAL ARTERY COMPRESSION IN CERVICAL SPONDYLOSIS , 1967, The Medical journal of Australia.

[34]  C. Slipman,et al.  Vascular supply to the lumbar spine: an intimate look at the lumbosacral nerve roots. , 2002, Pain physician.

[35]  M. Tachdjian,et al.  Dysphagia and hypertrophic spurring of the cervical spine. , 1960, The New England journal of medicine.

[36]  N. Ebraheim,et al.  Anatomic Basis of Lag Screw Placement in the Anterior Column of the Acetabulum , 1997, Clinical orthopaedics and related research.

[37]  T. Renshaw,et al.  Vertebral osteophytosis and dysphagia. Two case reports of the syndrome recently termed ankylosing hyperostosis. , 1973, The Journal of bone and joint surgery. American volume.

[38]  J. S. Derevenski Sex differences in activity-related osseous change in the spine and the gendered division of labor at Ensay and Wharram Percy, UK. , 2000 .

[39]  A. Newman,et al.  Cervical spine disease and dysphagia. Four new cases and a review of the literature. , 1981, The American journal of gastroenterology.

[40]  A. Yoskovitch,et al.  Cervical osteophytes presenting as unilateral vocal fold paralysis and dysphagia , 2001, The Journal of Laryngology & Otology.

[41]  W. Kenn,et al.  Accessory joints between basiocciput and atlas/axis in the median plane , 2005, Clinical anatomy.

[42]  E. McCloskey,et al.  Vertebral osteophytosis and vertebral deformities in an elderly population sample. , 2000, Wiener klinische Wochenschrift.

[43]  J. Snodgrass,et al.  Sex differences and aging of the vertebral column. , 2004, Journal of forensic sciences.

[44]  R. Yeasting,et al.  Anatomic considerations for uncovertebral involvement in cervical spondylosis. , 1997, Clinical orthopaedics and related research.

[45]  R. Jackson HEADACHES ASSOCIATED WITH DISORDERS OF THE CERVICAL SPINE , 1967, Headache.

[46]  M. Urist,et al.  Solubilized and insolubilized bone morphogenetic protein. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[47]  P. Eysel,et al.  Retro-pharyngeal obstruction in association with osteophytes of the cervical spine. , 2004, The Journal of bone and joint surgery. British volume.

[48]  D Resnick,et al.  Traction osteophytes of the lumbar spine: radiographic-pathologic correlation. , 1988, Radiology.

[49]  D. Kiel,et al.  Abdominal Aortic Calcification and Exostoses at the Hand and Lumbar Spine: The Framingham Study , 2006, Calcified Tissue International.

[50]  D. Mikaelian,et al.  Dysphagia Caused by Cervical Osteophytes , 1996 .

[51]  P. Cluzel,et al.  Traumatic Pseudoaneurysm of the Descending Thoracic Aorta Inflicted by a Spinal Osteophyte , 2005, Annals of vascular surgery.

[52]  H. Fewer,et al.  Two cases of dysphagia due to cervical spine osteophytes successfully treated surgically. , 1985, Canadian Medical Association journal.

[53]  A. Silman,et al.  The distribution, determinants, and clinical correlates of vertebral osteophytosis: a population based survey. , 1999, The Journal of rheumatology.

[54]  H. Junghanns,et al.  The human spine in health and disease , 1971 .

[55]  B. Mazières,et al.  Stenosis of the Lumbar Spinal Canal in Vertebral Ankylosing Hyperostosis , 1992, Spine.

[56]  H. P. Mosher,et al.  Exostoses of the cervical vertebrae as a cause for difficulty in swallowing , 1926 .

[57]  A. Silman,et al.  Lumbar disc degeneration: association between osteophytes, end-plate sclerosis and disc space narrowing , 2006, Annals of the rheumatic diseases.

[58]  J. Meyer,et al.  Vertebral artery compression in cervical spondylosis , 1960, Neurology.

[59]  S. Iglauer LXII A Case of Dysphagia Due to an Osteochondroma of the Cervical Spine—Osteotomy—Recovery , 1938 .

[60]  H. Schmitt,et al.  Radiographic Changes in the Lumbar Spine in Former Elite Athletes , 2004, Spine.

[61]  F. Stancampiano,et al.  Anterior Cervical Osteophytes: A Rare Cause of Dysphagia and Upper Airway Obstruction in Older Patients , 2002, Journal of The American Geriatrics Society.

[62]  Y. Toyama,et al.  Extraforaminal Entrapment of the Fifth Lumbar Spinal Nerve by Osteophytes of the Lumbosacral Spine: Anatomic Study and a Report of Four Cases , 2002, Spine.

[63]  D. Resnick,et al.  Diffuse idiopathic skeletal hyperostosis (DISH) [ankylosing hyperostosis of Forestier and Rotes-Querol]. , 1978, Seminars in arthritis and rheumatism.

[64]  H. Sawada,et al.  Dysphagia caused by an anterior cervical osteophyte: case report , 2004, Neuroradiology.

[65]  D. Cambier,et al.  Extrinsic risk factors for compromised blood flow in the vertebral artery: anatomical observations of the transverse foramina from C3 to C7 , 2005, Surgical and Radiologic Anatomy.

[66]  A. Clifton,et al.  Appearances of posterior osteophytes after sound anterior interbody fusion in the cervical spine: a high-definition computed myelographic study , 2004, Neuroradiology.