Computational dosimetry and treatment planning for Boron Neutron Capture Therapy

The technology for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT) has advanced significantly over the past few years. Because of the more complex nature of the problem, the computational methods that work well for treatment planning in photon radiotherapy are not applicable to BNCT. The necessary methods have, however, been developed and have been successfully employed both for research applications as well as human trials, although further improvements in speed are needed for routine clinical applications. Computational geometry for BNCT applications can be constructed directly from tomographic medical imagery and computed radiation dose distributions can be readily displayed in formats that are familiar to the radiotherapy community.

[1]  M. Mendelsohn,et al.  Neutron capture therapy with boron in the treatment of glioblastoma multiforme. , 1954, The American journal of roentgenology, radium therapy, and nuclear medicine.

[2]  T. Griffin,et al.  Fast neutron radiotherapy: where have we been and where are we going? The jury is still out--regarding Maor et al., IJROBP 32:599-604; 1995. , 1995, International journal of radiation oncology, biology, physics.

[3]  W. Sweet,et al.  The uses of nuclear disintegration in the diagnosis and treatment of brain tumor. , 1951, The New England journal of medicine.

[4]  T. Buchholz,et al.  Boron neutron capture therapy: a mechanism for achieving a concomitant tumor boost in fast neutron radiotherapy. , 1994, International journal of radiation oncology, biology, physics.

[5]  Floyd J. Wheeler,et al.  Creating and using a type of free-form geometry in Monte Carlo particle transport , 1993 .

[6]  R. Bergland,et al.  Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: Trial design and early clinical results , 1997, Journal of Neuro-Oncology.

[7]  D W Nigg,et al.  Demonstration of three-dimensional deterministic radiation transport theory dose distribution analysis for boron neutron capture therapy. , 1991, Medical physics.

[8]  Robert G. Zamenhof,et al.  Treatment Planning for Neutron Capture Therapy of Glioblastoma Multiforme Using an Epithermal Neutron Beam from the Mitr-II Research Reactor and Monte Carlo Simulation , 1992 .

[9]  H. B. Liu,et al.  Enhancement of the epithermal neutron beam used for boron neutron capture therapy. , 1994, International journal of radiation oncology, biology, physics.

[10]  W. Sweet,et al.  The possible use of neutron-capturing isotopes such as boron 10 in the treatment of neoplasms. II. Computation of the radiation energies and estimates of effects in normal and neoplastic brain. , 1952, The Journal of clinical investigation.

[11]  D. Nigg.  Methods for radiation dose distribution analysis and treatment planning in boron neutron capture therapy. , 1994, International journal of radiation oncology, biology, physics.

[12]  R. S. Stone.  Neutron therapy and specific ionization. , 1948, The American journal of roentgenology and radium therapy.

[13]  Robert G. Zamenhof,et al.  Microdosimetry for boron neutron capture therapy: A review , 1997, Journal of Neuro-Oncology.

[14]  R. A. Forster,et al.  MCNP - a general Monte Carlo code for neutron and photon transport , 1985 .

[15]  J. Moran,et al.  Macroscopic geometric heterogeneity effects in radiation dose distribution analysis for boron neutron capture therapy. , 1992, Medical physics.

[16]  D. Nigg,et al.  Three-dimensional radiation dose distribution analysis for boron neutron capture therapy , 1992 .

[17]  D. Gabel,et al.  The Monte Carlo Simulation of the Biological Effect of the 10B(n,α)7Li Reaction in Cells and Tissue and Its Implication for Boron Neutron Capture Therapy , 1987 .

[18]  T. Blue,et al.  Removal-Diffusion Theory for Calculation of Neutron Distributions in BNCT , 1993 .

[19]  D. Gabel,et al.  The Monte Carlo simulation of the biological effect of the 10B(n, alpha)7Li reaction in cells and tissue and its implication for boron neutron capture therapy. , 1987, Radiation research.

[20]  Barry J. Allen,et al.  Progress in Neutron Capture Therapy for Cancer , 2012, Springer US.

[21]  C. Dunford,et al.  Data formats and procedures for the Evaluated Nuclear Data File, ENDF , 1975 .

[22]  W. Sweet,et al.  Pathological study of eight patients with glioblastoma multiforme treated by neutroncapture therapy using boron 10 , 1955, Cancer.

[23]  R. Zamenhof,et al.  A novel approach to the microdosimetry of neutron capture therapy. Part I. High-resolution quantitative autoradiography applied to microdosimetry in neutron capture therapy. , 1995, Radiation research.

[24]  Briesmeister.  MCNP: a general Monte Carlo code for neutron and photon transport. Version 3A. Revision 2 , 1986 .

[25]  P. Gavin,et al.  Computer Modeling the Boron Compound Factor in Brain Tumors , 1993 .

[26]  F. Wheeler.  Microdosimetric calculations of boron-drug compound factors for boron neutron capture therapy , 1992 .

[27]  M. A. Davis,et al.  Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds. , 1967, Journal of medicinal chemistry.

[28]  K. Frankel,et al.  Biological Effectiveness of Recoil Protons from Neutrons of Energy 5 keV to 5 MeV , 1993 .

[29]  B. Murray,et al.  The effect of geometry on capillary wall dose for boron neutron capture therapy. , 1976, Physics in medicine and biology.