Alum Catalyzed Convenient Synthesis of Quino[2,3-b] [1,5]benzoxazepine α-Aminophosphonate Derivatives

We have described an efficient synthesis of quino[2,3-b][1,5]benzoxazepine α-aminophosphonate derivatives by the nucleophilic addition oftriethyl phosphite to substituted quino[2,3-b][1,5]benzoxazepines promoted by easily available, inexpensive and mild catalyst KAl(SO 4 ) 2 ·12H 2 0 (alum). The reactions proceed smoothly at room temperature under solvent-free reaction conditions and providing high yield of product in very short reaction time.

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