The relationship between white matter brain metabolites and cognition in normal aging: The GENIE study

[1]  J R Griffiths,et al.  Aging of the adult human brain: In vivo quantitation of metabolite content with proton magnetic resonance spectroscopy , 1999, Journal of magnetic resonance imaging : JMRI.

[2]  B. Pakkenberg,et al.  Age-Induced White Matter Changes in the Human Brain: A Stereological Investigation , 1997, Neurobiology of Aging.

[3]  A. Alavi,et al.  MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. , 1987, AJR. American journal of roentgenology.

[4]  L. J. Whalley,et al.  White matter integrity and cognition in childhood and old age , 2006, Neurology.

[5]  Clifford R Jack,et al.  1H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease , 2002, Journal of the International Neuropsychological Society.

[6]  S. Provencher.  Estimation of metabolite concentrations from localized in vivo proton NMR spectra , 1993, Magnetic resonance in medicine.

[7]  G J Barker,et al.  A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis. , 2000, Magnetic resonance imaging.

[8]  B B Reiss,et al.  The reliability and validity of the Mini-Mental State in a British community survey. , 1989, Journal of psychiatric research.

[9]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[10]  G J Barker,et al.  Quantitative analysis of short echo time 1H‐MRSI of cerebral gray and white matter , 2000, Magnetic resonance in medicine.

[11]  K. Berman,et al.  Context-dependent, neural system-specific neurophysiological concomitants of ageing: mapping PET correlates during cognitive activation. , 1999, Brain : a journal of neurology.

[12]  P. Landfield,et al.  Brain Creatine Kinase with Aging in F-344 Rats: Analysis by Saturation Transfer Magnetic Resonance Spectroscopy , 1997, Neurobiology of Aging.

[13]  T. Tombaugh,et al.  The Mini‐Mental State Examination: A Comprehensive Review , 1992, Journal of the American Geriatrics Society.

[14]  Karen J. Ferguson,et al.  Intracranial capacity and brain volumes are associated with cognition in healthy elderly men , 2002, Neurology.

[15]  Boris Suchan,et al.  Cortico-subcortical contributions to executive control. , 2004, Acta psychologica.

[16]  T Horinouchi,et al.  Development and aging of the cerebrum: assessment with proton MR spectroscopy. , 2001, AJNR. American journal of neuroradiology.

[17]  Perminder S. Sachdev,et al.  Cognitive correlates of 1H MRS measures in the healthy elderly brain , 2005, Brain Research Bulletin.

[18]  Klaas Nicolay,et al.  1H MR spectroscopy of the brain: absolute quantification of metabolites. , 2006, Radiology.

[19]  G J Blauw,et al.  Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[20]  R. Mrak,et al.  Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain , 1998, Acta Neuropathologica.

[21]  D. Leibfritz,et al.  Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. , 1993, Developmental neuroscience.

[22]  P. Hof,et al.  Cortical Microinfarcts and Demyelination Significantly Affect Cognition in Brain Aging , 2004, Stroke.

[23]  J. Morrison,et al.  Life and death of neurons in the aging brain. , 1997, Science.

[24]  K. R. Ridderinkhof,et al.  Age-related changes in the efficiency of cognitive processing across the life span. , 2004, Acta psychologica.

[25]  E. Rostrup,et al.  Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study , 2000, The Lancet.

[26]  M W Weiner,et al.  Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging , 2001, Magnetic resonance in medicine.

[27]  M. O’Sullivan,et al.  White matter damage on diffusion tensor imaging correlates with age-related cognitive decline , 2006, Neurology.

[28]  S. Provencher.  Automatic quantitation of localized in vivo 1H spectra with LCModel , 2001, NMR in biomedicine.

[29]  T. Erkinjuntti,et al.  White matter changes in healthy elderly persons correlate with attention and speed of mental processing. , 1993, Archives of neurology.

[30]  H. Brody,et al.  Structural Changes in the Aging Nervous System , 1970 .

[31]  T. Shirao,et al.  Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease. , 1999, Journal of neuropathology and experimental neurology.

[32]  Paul D. Coleman,et al.  Neuron numbers and dendritic extent in normal aging and Alzheimer's disease , 1987, Neurobiology of Aging.

[33]  Derek K. Jones,et al.  Evidence for cortical “disconnection” as a mechanism of age-related cognitive decline , 2001, Neurology.

[34]  M. Rieger,et al.  Inhibition of ongoing responses following frontal, nonfrontal, and basal ganglia lesions. , 2003, Neuropsychology.

[35]  L. Defebvre,et al.  A case of severe dysexecutive syndrome consecutive to chronic bilateral pallidal stimulation , 2000, Neuropsychologia.

[36]  B. Trapp,et al.  N‐acetylaspartate is an axon‐specific marker of mature white matter in vivo: A biochemical and immunohistochemical study on the rat optic nerve , 2002, Annals of neurology.

[37]  Niels D Prins,et al.  Cerebral small-vessel disease and decline in information processing speed, executive function and memory. , 2005, Brain : a journal of neurology.

[38]  B L Hart,et al.  Biochemical markers of cognition: a proton MR spectroscopy study of normal human brain. , 1999, Neuroreport.

[39]  G Helms,et al.  Analysis of 1.5 Tesla proton MR spectra of human brain using LCModel and an imported basis set. , 1999, Magnetic resonance imaging.

[40]  K O Lim,et al.  In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. , 1999, Archives of general psychiatry.

[41]  K. Lim,et al.  Estimating NAA in cortical gray matter with applications for measuring changes due to aging , 1997, Magnetic resonance in medicine.

[42]  Morris H. Baslow,et al.  N-Acetylaspartate in the Vertebrate Brain: Metabolism and Function , 2003, Neurochemical Research.

[43]  Chris Boesch,et al.  Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects , 2005, Magnetic resonance in medicine.

[44]  Anand R. Kumar,et al.  Brain Metabolites and Cognitive Function among Older Depressed and Healthy Individuals Using 2D MR Spectroscopy , 2004, Neuropsychopharmacology.

[45]  N Roberts,et al.  A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. , 2001, Cerebral cortex.

[46]  Ian Marshall,et al.  Magnetic resonance spectroscopy and cognitive function in healthy elderly men. , 2002, Brain : a journal of neurology.

[47]  H. Brodaty,et al.  Dual Voxel Proton Magnetic Resonance Spectroscopy in the Healthy Elderly: Subcortical-Frontal Axonal N-Acetylaspartate Levels Are Correlated with Fluid Cognitive Abilities Independent of Structural Brain Changes , 2000, NeuroImage.

[48]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[49]  D. Head,et al.  Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. , 1997, Cerebral cortex.

[50]  C. Gryfe.  Mechanical Concepts in Cardiovascular and Pulmonary Physiology. , 1978 .

[51]  Mark J. West,et al.  New stereological methods for counting neurons , 1993, Neurobiology of Aging.

[52]  J J Mallet,et al.  Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study. , 2001, AJNR. American journal of neuroradiology.

[53]  Ian J. Deary,et al.  The Stability of Individual Differences in Mental Ability from Childhood to Old Age: Follow-up of the 1932 Scottish Mental Survey , 2000 .

[54]  K O Lim,et al.  In vivo spectroscopic quantification of the N‐acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: Effects of normal aging , 1999, Magnetic resonance in medicine.

[55]  Cheryl L Grady,et al.  Age‐related differences in the functional connectivity of the hippocampus during memory encoding , 2003, Hippocampus.

[56]  H BRODY,et al.  Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex , 1955, The Journal of comparative neurology.

[57]  H S Markus,et al.  Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[58]  Matthijs Oudkerk,et al.  Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. , 2000 .