Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography.
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N. Vermeulen | J. Meerman | J. Kool | H. Irth | S. van Liempd | J. Reinen | T. Schenk | Jelle Reinen
[1] J. van der Greef,et al. Screening of Natural Products Extracts for the Presence of Phosphodiesterase Inhibitors Using Liquid Chromatography Coupled Online to Parallel Biochemical Detection and Chemical Characterization , 2003, Journal of biomolecular screening.
[2] J. Bolton,et al. Screening botanical extracts for quinoid metabolites. , 2001, Chemical research in toxicology.
[3] F. Guengerich,et al. Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. , 1999, Mutation research.
[4] T. Rose,et al. Determination of lonazolac and its hydroxy and O-sulfated metabolites by on-line sample preparation liquid chromatography with fluorescence detection. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[5] Vinod P. Shah,et al. Bioanalytical Method Validation—A Revisit with a Decade of Progress , 2000, Pharmaceutical Research.
[6] E. Hsu,et al. A novel multi‐coaxial hollow fiber bioreactor for adherent cell types. Part 1: Hydrodynamic studies , 2002, Biotechnology and bioengineering.
[7] F. Guengerich,et al. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. , 2001, Chemical research in toxicology.
[8] Rongda Xu,et al. Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries. , 2004, Journal of pharmaceutical and biomedical analysis.
[9] J. van der Greef,et al. Gradient reversed-phase liquid chromatography coupled on-line to receptor-affinity detection based on the urokinase receptor. , 1998, Journal of chromatography. B, Biomedical sciences and applications.
[10] N. Vermeulen,et al. Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates. , 2001, Chemical research in toxicology.
[11] N. Vermeulen,et al. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. , 1996, Biochemical pharmacology.
[12] J. van der Greef,et al. Reversed-phase liquid chromatography coupled on-line to receptor affinity detection based on the human estrogen receptor. , 1996, Analytical chemistry.
[13] T. Rose,et al. Determination of testosterone metabolites in human hepatocytes. I. Development of an on-line sample preparation liquid chromatography technique and mass spectroscopic detection of 6beta-hydroxytestosterone. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[14] N. Vermeulen,et al. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. , 1999, Critical reviews in toxicology.
[15] L. Griffith,et al. Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor. , 2002, Tissue engineering.
[16] R. Mayer,et al. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. , 1985, Biochemical pharmacology.
[17] R. Mayer,et al. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. , 1974, Drug metabolism and disposition: the biological fate of chemicals.
[18] Jun Kameoka,et al. Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection. , 2003, Analytical chemistry.
[19] M. Relling,et al. Pharmacogenomics: translating functional genomics into rational therapeutics. , 1999, Science.
[20] F. Oesch,et al. New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures , 2003, Drug metabolism reviews.
[21] J. Bolton,et al. Metabolic screening using on-line ultrafiltration mass spectrometry. , 1998, Drug metabolism and disposition: the biological fate of chemicals.
[22] H. Yamazaki,et al. Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes. , 1997, Drug metabolism and disposition: the biological fate of chemicals.
[23] B. Witholt,et al. Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis. , 2001, Current opinion in biotechnology.
[24] T. Rushmore,et al. Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites. , 2000, Metabolic engineering.
[25] N. Vermeulen,et al. Oxygen and xenobiotic reductase activities of cytochrome P450. , 1995, Critical reviews in toxicology.
[26] Christopher K Atterwill,et al. In vitro preclinical lead optimisation technologies (PLOTs) in pharmaceutical development. , 2002, Toxicology letters.
[27] C. Poole,et al. Contributions of theory to method development in solid-phase extraction. , 2000, Journal of chromatography. A.