Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

[1]  F. Alameda,et al.  Oxidative stress triggers the amyloidogenic pathway in human vascular smooth muscle cells , 2008, Neurobiology of Aging.

[2]  W. Henley,et al.  Supplementation with antioxidants and folinic acid for children with Down’s syndrome: randomised controlled trial , 2008, BMJ : British Medical Journal.

[3]  T. Bayer,et al.  Review on the APP/PS1KI mouse model: intraneuronal Aβ accumulation triggers axonopathy, neuron loss and working memory impairment , 2008, Genes, brain, and behavior.

[4]  S. Paul,et al.  Geranylgeranyl pyrophosphate stimulates γ‐secretase to increase the generation of Aβ and APP‐CTFγ , 2008 .

[5]  K. Yaffe.  Antioxidants and prevention of cognitive decline: does duration of use matter? , 2007, Archives of internal medicine.

[6]  W. Markesbery,et al.  Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease , 2007, Nucleic acids research.

[7]  K. Yamakawa,et al.  Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome. , 2006, Human molecular genetics.

[8]  Ahmad Salehi,et al.  Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration , 2006, Neuron.

[9]  Jun Tan,et al.  ADAM10 Activation Is Required for Green Tea (–)-Epigallocatechin-3-gallate-induced α-Secretase Cleavage of Amyloid Precursor Protein* , 2006, Journal of Biological Chemistry.

[10]  F. Pallardó,et al.  Multiple evidence for an early age pro-oxidant state in Down Syndrome patients , 2006, Biogerontology.

[11]  J. Wuu,et al.  Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease , 2006, Journal of neurochemistry.

[12]  S. Hall,et al.  Effects of increasing task load on memory impairment in adults with Down syndrome. , 2005, American journal of mental retardation : AJMR.

[13]  D. Bennett,et al.  Vitamin E and donepezil for the treatment of mild cognitive impairment. , 2005, The New England journal of medicine.

[14]  O. Isacson,et al.  Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice , 2005, Experimental Neurology.

[15]  G. Perry,et al.  β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways , 2005, Journal of neurochemistry.

[16]  C. Epstein,et al.  Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome , 2004, The Journal of comparative neurology.

[17]  A. Granholm,et al.  Minocycline prevents cholinergic loss in a mouse model of Down's syndrome , 2004, Annals of neurology.

[18]  Alberto C. S. Costa,et al.  Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome , 2004, Behavioural Brain Research.

[19]  A. Granholm,et al.  Behavioral and neurobiological markers of Alzheimer’s disease in Ts65Dn mice: effects of estrogen , 2004, Neurobiology of Aging.

[20]  In‐Seon Lee,et al.  Effects of vitamin E on oxidative stress and membrane fluidity in brain of streptozotocin-induced diabetic rats. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[21]  S. K. Zaidi,et al.  Antioxidant potential of vitamins A, E and C in modulating oxidative stress in rat brain. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[22]  Steven T. DeKosky,et al.  Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction , 2003, Journal of Chemical Neuroanatomy.

[23]  A. Azzi,et al.  The role of α-tocopherol in preventing disease: from epidemiology to molecular events , 2003 .

[24]  C. Colton,et al.  Redox regulation of neuronal migration in a Down Syndrome model. , 2003, Free radical biology & medicine.

[25]  C. Epstein,et al.  App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome , 2003, The Journal of Neuroscience.

[26]  P. Yarowsky,et al.  Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome , 2003, Journal of neuroscience research.

[27]  W. Willett,et al.  High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. , 2003, The American journal of clinical nutrition.

[28]  A. Granholm,et al.  Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome , 2003, Neuroscience Research.

[29]  A. Granholm,et al.  Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome , 2003, Behavioural Brain Research.

[30]  A. Granholm,et al.  Behavioral comparison of 4 and 6 month-old Ts65Dn mice: Age-related impairments in working and reference memory , 2003, Behavioural Brain Research.

[31]  C. Geula,et al.  Loss of calbindin‐D28k from aging human cholinergic basal forebrain: Relation to neuronal loss , 2003, The Journal of comparative neurology.

[32]  A. Granholm,et al.  Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome , 2002, Physiology & Behavior.

[33]  Kouichi Abe,et al.  Cognitive Impairment of Rats Caused by Oxidative Stress and Aging, and Its Prevention by Vitamin E , 2002, Annals of the New York Academy of Sciences.

[34]  Ahmad Salehi,et al.  Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  L. Onstead,et al.  Convertases other than furin cleave β‐secretase to its mature form , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  I. Bourdel-Marchasson,et al.  Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients. , 2001, Age and ageing.

[37]  A. Agmon,et al.  Diverse Types of Interneurons Generate Thalamus-Evoked Feedforward Inhibition in the Mouse Barrel Cortex , 2001, The Journal of Neuroscience.

[38]  S. Krinsky-McHale,et al.  Sequence of cognitive decline in dementia in adults with Down's syndrome. , 2000, Journal of intellectual disability research : JIDR.

[39]  E. Masliah,et al.  Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoproteinE‐deficient mice , 2000 .

[40]  V. Denenberg,et al.  In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze , 2000, Physiology & Behavior.

[41]  S. Schuchmann,et al.  THIS ARTICLE HAS BEEN RETRACTED: Diminished Glutathione Levels Cause Spontaneous and Mitochondria‐Mediated Cell Death in Neurons from Trisomy 16 Mice: , 2000, Journal of neurochemistry.

[42]  A. Granholm,et al.  Loss of Cholinergic Phenotype in Basal Forebrain Coincides with Cognitive Decline in a Mouse Model of Down's Syndrome , 2000, Experimental Neurology.

[43]  D. Cornblath,et al.  Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy , 2000, Neurology.

[44]  F. Gage,et al.  Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[45]  K. Macleod,et al.  Biomarkers of oxidative stress are significantly elevated in Down syndrome. , 1998, Free radical biology & medicine.

[46]  M. Mattson,et al.  Effects of amyloid precursor protein derivatives andoxidative stress on basal forebrain cholinergic systems inALZHEIMERS disease , 1998, International Journal of Developmental Neuroscience.

[47]  D. Rader,et al.  Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice , 1998, Nature Medicine.

[48]  P. Bickford,et al.  Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits , 1998, The Journal of Neuroscience.

[49]  A. M. Insausti,et al.  Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome , 1998, Neuroscience Letters.

[50]  M. Lynch,et al.  Dietary Supplementation with Vitamin E Reverses the Age-related Deficit in Long Term Potentiation in Dentate Gyrus* , 1998, The Journal of Biological Chemistry.

[51]  M. Dierssen,et al.  Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome , 1998, Neuroscience Letters.

[52]  M. Tabaton,et al.  Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress , 1998, Journal of neurochemistry.

[53]  M. Mattson,et al.  Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[54]  S. Rapoport,et al.  Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome , 1997, Neuropharmacology.

[55]  Mark A. Smith,et al.  4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease , 1997, Journal of neurochemistry.

[56]  P Woodbury,et al.  A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. , 1997, The New England journal of medicine.

[57]  D. Holtzman,et al.  Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[58]  A. Björklund,et al.  Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[59]  B. Yankner,et al.  Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro , 1995, Nature.

[60]  R. Bronson,et al.  A mouse model for Down syndrome exhibits learning and behaviour deficits , 1995, Nature Genetics.

[61]  W. D. Ehmann,et al.  Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease , 1995, Neurology.

[62]  E. Mufson,et al.  TrkA‐immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin , 1994, The Journal of comparative neurology.

[63]  M. Mattson,et al.  Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury , 1994, Experimental Neurology.

[64]  D. Holtzman,et al.  Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age‐related neurodegeneration , 1993, Neurology.

[65]  M. Somerville,et al.  Reduction of calbindin-28k mRNA levels in Alzheimer as compared to Huntington hippocampus. , 1993, Brain research. Molecular brain research.

[66]  B. R. Sastry,et al.  Induction of hippocampal long-term potentiation by α-tocopherol , 1993, Brain Research.

[67]  J. Shioi,et al.  Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells , 1992, Journal of neuroscience research.

[68]  G. Cole,et al.  Vitamin E protects nerve cells from amyloid βprotein toxicity , 1992 .

[69]  H. Gundersen,et al.  Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator , 1991, The Anatomical record.

[70]  T. Collier,et al.  Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment , 1989, Brain Research.

[71]  H. J. G. Gundersen,et al.  The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis , 1988, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[72]  M. Casanova,et al.  Abnormalities of the nucleus basalis in Down's syndrome , 1985, Annals of neurology.

[73]  H. Wiśniewski,et al.  Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome , 1985, Annals of neurology.

[74]  O. Steward,et al.  On the role of hippocampal connections in the performance of place and cue tasks: comparisons with damage to hippocampus. , 1984, Behavioral neuroscience.

[75]  C. J. Sells,et al.  Vitamin and mineral supplementation in Down's syndrome. , 1983, Pediatrics.

[76]  A. Levey,et al.  Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey , 1983, The Journal of comparative neurology.

[77]  J. Coyle,et al.  Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. , 1982, Science.

[78]  G. Blessed,et al.  NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA , 1977, The Lancet.

[79]  S. Paul,et al.  Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[80]  E. Mufson,et al.  Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease. , 2006, Progress in brain research.

[81]  J. Benito-León,et al.  Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease , 2005, Journal of Neural Transmission.

[82]  A. Azzi,et al.  The role of alpha-tocopherol in preventing disease: from epidemiology to molecular events. , 2003, Molecular aspects of medicine.

[83]  I. Klejbor,et al.  Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain. , 2002, Folia morphologica.

[84]  E. Masliah,et al.  Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice. , 2000, The European journal of neuroscience.

[85]  M. Mattson,et al.  Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. , 1994, Experimental neurology.

[86]  B. R. Sastry,et al.  Induction of hippocampal long-term potentiation by alpha-tocopherol. , 1993, Brain research.

[87]  G. Cole,et al.  Vitamin E protects nerve cells from amyloid beta protein toxicity. , 1992, Biochemical and biophysical research communications.

[88]  M. Davisson,et al.  Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome. , 1990, Progress in clinical and biological research.