Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway

[1]  G. Semenza,et al.  HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus , 2001, Cell.

[2]  Denis Mottet,et al.  Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation. , 2001, Free radical biology & medicine.

[3]  A. Harris,et al.  Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. , 2001, Cancer research.

[4]  J. Haddad,et al.  A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α , 2001 .

[5]  J. Gutkind,et al.  MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. , 2001, Biochemical and biophysical research communications.

[6]  A. Tomida,et al.  Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia , 2001, Oncogene.

[7]  R. Busse,et al.  Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells: Role of the p22phox-Containing NADPH Oxidase , 2001, Circulation research.

[8]  T. Hunter,et al.  Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. , 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[9]  L. del Peso,et al.  Hypoxia Induces the Activation of the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway in PC12 Cells , 2001, The Journal of Biological Chemistry.

[10]  E. Hur,et al.  Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha. , 2001 .

[11]  Michael I. Wilson,et al.  Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.

[12]  M. Ivan,et al.  HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing , 2001, Science.

[13]  A. Giaccia,et al.  Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. , 2001, Cancer research.

[14]  D. O’Rourke,et al.  Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia. , 2000, Cancer research.

[15]  J. Pouysségur,et al.  Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. , 2000, Biochemical pharmacology.

[16]  H. Chung,et al.  Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis , 2000, Oncogene.

[17]  J. Gutkind,et al.  The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. , 2000, Cancer research.

[18]  J. Pouysségur,et al.  Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. , 2000, The Journal of biological chemistry.

[19]  M. Gassmann,et al.  Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation , 2000 .

[20]  J. Caro,et al.  Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. , 2000, The Biochemical journal.

[21]  E. Van Obberghen,et al.  Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways* , 2000, The Journal of Biological Chemistry.

[22]  W. Jelkmann,et al.  Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells. , 2000, Kidney international.

[23]  G. Semenza,et al.  Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. , 2000, Cancer research.

[24]  D. Mottet,et al.  ERK activation upon hypoxia: involvement in HIF‐1 activation , 2000, FEBS letters.

[25]  A. Koong,et al.  Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.

[26]  J. Pouysségur,et al.  p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1* , 1999, The Journal of Biological Chemistry.

[27]  W. Jelkmann,et al.  Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1 , 1999 .

[28]  B. Shilo,et al.  Insulin induces transcription of target genes through the hypoxia‐inducible factor HIF‐1α/ARNT , 1998, The EMBO journal.

[29]  J. Pouysségur,et al.  p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts* , 1998, The Journal of Biological Chemistry.

[30]  F. Hobbs,et al.  Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase* , 1998, The Journal of Biological Chemistry.

[31]  A. Giaccia,et al.  Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. , 1997, Blood.

[32]  M. Gassmann,et al.  Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1* , 1997, The Journal of Biological Chemistry.

[33]  Philip R. Cohen,et al.  PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*) , 1995, The Journal of Biological Chemistry.

[34]  J. Pfeilschifter,et al.  Distinct signaling pathways mediate phorbol-ester-induced and cytokine-induced inhibition of erythropoietin gene expression. , 1994, European journal of biochemistry.

[35]  K Y Hui,et al.  A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). , 1994, The Journal of biological chemistry.

[36]  M A Goldberg,et al.  The regulated expression of erythropoietin by two human hepatoma cell lines. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[37]  T. Hunter,et al.  Phosphatidylinositol 3-Kinase Signaling Controls Levels of Hypoxia-inducible Factor 11 , 2000 .

[38]  F. White,et al.  VEGF mRNA is reversibly stabilized by hypoxia and persistently stabilized in VEGF-overexpressing human tumor cell lines. , 1995, Growth factors.

[39]  H. Scholz,et al.  Insulin-like growth factors decrease oxygen-regulated erythropoietin production by human hepatoma cells (Hep G2). , 1992, The American journal of physiology.