Molecular mechanisms of selector gene function and evolution.

Selector proteins regulate the formation and identity of animal body regions, organs, tissues, and cell types. Recent studies have focused on the regulation of the DNA binding and transcriptional regulatory activity of this special class of transcription factors. Elucidation of the architecture of selector-regulated target gene enhancers and gene networks, and comparative studies of selector protein function are providing important insights into the evolution of development and morphology.

[1]  E. Olson,et al.  The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development. , 2001, Development.

[2]  R. Holmgren,et al.  Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer. , 1999, Development.

[3]  R. Mann,et al.  Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins. , 1996, Trends in genetics : TIG.

[4]  S. Carroll,et al.  Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites. , 2002, Development.

[5]  H. Krause,et al.  FTZ‐Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs , 2001, The EMBO journal.

[6]  A. Garcı́a-Bellido.  Genetic control of wing disc development in Drosophila. , 2008, Ciba Foundation symposium.

[7]  P. Dong,et al.  Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity. , 2000, Development.

[8]  G. Morata,et al.  The functions of pannier during Drosophila embryogenesis. , 2001, Development.

[9]  R. Mann,et al.  Legs, Eyes, or Wings--Selectors and Signals Make the Difference , 2001, Science.

[10]  L. Pick,et al.  The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains , 2001, Mechanisms of Development.

[11]  S. Carroll,et al.  Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. , 1993, Development.

[12]  D. Schmucker,et al.  Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. , 1997, Genes & development.

[13]  W. Gehring,et al.  Direct regulatory interaction of the eyeless protein with an eye-specific enhancer in the sine oculis gene during eye induction in Drosophila. , 1999, Development.

[14]  S. Carroll,et al.  Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere. , 1998, Genes & development.

[15]  William McGinnis,et al.  Hox protein mutation and macroevolution of the insect body plan , 2002, Nature.

[16]  M. Akam,et al.  Maternal expression and early zygotic regulation of the Hox3/zen gene in the grasshopper Schistocerca gregaria , 2000, Evolution & development.

[17]  G. Church,et al.  Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx , 2000, Current Biology.

[18]  J. Modolell,et al.  The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila. , 1999, Genes & development.

[19]  M. Frasch,et al.  Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. , 1997, Development.

[20]  W. Gehring,et al.  Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. , 1994, Science.

[21]  P. Beachy,et al.  Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. , 1995, The EMBO journal.

[22]  Richard S. Mann,et al.  Control of antennal versus leg development in Drosophila , 1998, Nature.

[23]  M. Laubichler.  Review of: Carroll, Sean B., Jennifer K. Grenier and Scott D. Weatherbee: From DNA to diversity : molecular genetics and the evolution of animal design. Malden, Mass [u.a.]: Blackwell Science 2001 , 2003 .

[24]  J. Botas,et al.  Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm. , 2001, Development.

[25]  Fulvio Mavilio,et al.  The Recruitment of SOX/OCT Complexes and the Differential Activity of HOXA1 and HOXB1 Modulate the Hoxb1Auto-regulatory Enhancer Function* , 2001, The Journal of Biological Chemistry.

[26]  S. Carroll,et al.  From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design , 2000 .

[27]  J. Botas,et al.  Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis , 1994, Cell.

[28]  M. Frasch,et al.  Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors. , 2001, Developmental biology.

[29]  M. Bate,et al.  twist: A Myogenic Switch in Drosophila , 1996, Science.

[30]  L. Pick,et al.  Drosophila fushi tarazu a gene on the border of homeotic function , 2001, Current Biology.

[31]  R. Mann,et al.  The Ground State of the Ventral Appendage in Drosophila , 2001, Science.

[32]  S. Carroll,et al.  Binding of the Vestigial co-factor switches the DNA-target selectivity of the Scalloped selector protein. , 2001, Development.

[33]  M. Akam,et al.  Evolution of Ftz protein function in insects , 2001, Current Biology.

[34]  M. Scott,et al.  Regulation of a decapentaplegic midgut enhancer by homeotic proteins. , 1994, Development.

[35]  A. Bagri,et al.  Salivary gland determination in Drosophila: a salivary-specific, fork head enhancer integrates spatial pattern and allows fork head autoregulation. , 2001, Developmental biology.

[36]  Richard S. Mann,et al.  Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx , 1995, Cell.

[37]  M. Frasch,et al.  Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. , 1998, Genes & development.

[38]  Juan Botas,et al.  Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less , 1992, Cell.

[39]  M. Rosenfeld,et al.  Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. , 2000, Science.

[40]  S. Mango,et al.  Regulation of Organogenesis by the Caenorhabditis elegans FoxA Protein PHA-4 , 2002, Science.

[41]  G. Struhl,et al.  A homoeotic mutation transforming leg to antenna in Drosophila , 1981, Nature.

[42]  W. Gehring,et al.  Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer. , 2002, Development.

[43]  G. Morata,et al.  Control of Drosophila adult pattern by extradenticle. , 1995, Development.

[44]  Urs Schmidt-Ott,et al.  A single Hox3 gene with composite bicoid and zerknüllt expression characteristics in non-Cyclorrhaphan flies , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Juan Botas,et al.  The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein , 1994, Cell.

[46]  M. Levine.  Evolutionary biology: How insects lose their limbs , 2002, Nature.

[47]  S. Carroll,et al.  Ultrabithorax function in butterfly wings and the evolution of insect wing patterns , 1999, Current Biology.

[48]  G. Jürgens,et al.  Proximal—distal pattern formation in Drosophila: cell autonomous requirement for Distal‐less gene activity in limb development , 1989, The EMBO journal.

[49]  R. Mann,et al.  The developmental and molecular biology of genes that subdivide the body of Drosophila. , 2000, Annual review of cell and developmental biology.

[50]  M. Frasch,et al.  biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila. , 2001, Genes & development.

[51]  T Marty,et al.  Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. , 1999, Development.

[52]  M. Telford,et al.  Of mites and zen: expression studies in a chelicerate arthropod confirm zen is a divergent Hox gene , 1998, Development Genes and Evolution.

[53]  B. Black,et al.  Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. , 1998, Annual review of cell and developmental biology.

[54]  K. Umesono,et al.  Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[55]  Hyung Don Ryoo,et al.  Nuclear Translocation of Extradenticle Requires homothorax , which Encodes an Extradenticle-Related Homeodomain Protein , 1997, Cell.

[56]  E. Sánchez-Herrero,et al.  Patterning mechanisms in the body trunk and the appendages of Drosophila. , 1999, Development.

[57]  Stephen S. Gisselbrecht,et al.  Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors , 2000, Cell.

[58]  M. Affolter,et al.  A HOX complex, a repressor element and a 50 bp sequence confer regional specificity to a DPP-responsive enhancer. , 2001, Development.

[59]  E. Sánchez-Herrero,et al.  Functional similarity in appendage specification by the Ultrabithorax and abdominal‐A Drosophila HOX genes. , 1996, The EMBO journal.

[60]  S. Carroll,et al.  Control of a Genetic Regulatory Network by a Selector Gene , 2001, Science.

[61]  K. White,et al.  Patterns of Gene Expression During Drosophila Mesoderm Development , 2001, Science.

[62]  D. Tautz,et al.  A Hox class 3 orthologue from the spider Cupiennius salei is expressed in a Hox-gene-like fashion , 1998, Development Genes and Evolution.

[63]  R. Mann,et al.  The control of trunk Hox specificity and activity by Extradenticle. , 1999, Genes & development.

[64]  W. A. Johnson,et al.  Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor. , 2000, Development.