Automated Classification of Focal and Non-Focal EEG Signals Based on Bivariate Empirical Mode Decomposition

The chapter presents a new approach of computer aided diagnosis of focal electroencephalogram (EEG) signals by applying bivariate empirical mode decomposition (BEMD). Firstly, the focal and non-focal EEG signals are decomposed using the BEMD, which results in intrinsic mode functions (IMFs) corresponding to each signal. Secondly, bivariate bandwidths namely, amplitude bandwidth, precession bandwidth, and deformation bandwidth are computed for each obtained IMF. Interquartile range (IQR) values of bivariate bandwidths of IMFs are employed as the features for classification. In order to perform classification least squares support vector machine (LS-SVM) is used. The results of the experiment suggest that the computed bivariate bandwidths are significantly useful to discriminate focal EEG signals. The resultant classification accuracy obtained using proposed methodology, applied on the Bern-Barcelona EEG database, is 84.01%. The obtained results are encouraging and the proposed methodology can be helpful for identification of epileptogenic focus.

[1]  Muhammad Sarfraz Intelligent Computer Vision and Image Processing: Innovation, Application, and Design , 2013 .

[2]  U. Rajendra Acharya,et al.  Application of Entropy Measures on Intrinsic Mode Functions for the Automated Identification of Focal Electroencephalogram Signals , 2015, Entropy.

[3]  K. Lehnertz,et al.  Spatial Distribution of Neuronal Complexity Loss in Neocortical Lesional Epilepsies , 2000, Epilepsia.

[4]  Sandipan Pati,et al.  Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies , 2010, Cleveland Clinic Journal of Medicine.

[5]  Yan Li,et al.  Clustering technique-based least square support vector machine for EEG signal classification , 2011, Comput. Methods Programs Biomed..

[6]  J Gutiérrez,et al.  Analysis and localization of epileptic events using wavelet packets. , 2001, Medical engineering & physics.

[7]  Ram Bilas Pachori,et al.  Classification of cardiac sound signals using constrained tunable-Q wavelet transform , 2014, Expert Syst. Appl..

[8]  Mark R. Bower,et al.  Synchrony in normal and focal epileptic brain: the seizure onset zone is functionally disconnected. , 2010, Journal of neurophysiology.

[9]  U. Rajendra Acharya,et al.  An automatic detection of focal EEG signals using new class of time-frequency localized orthogonal wavelet filter banks , 2017, Knowl. Based Syst..

[10]  Yoshitaka Sakurai,et al.  Adaptive Kansei Search Method Using User's Subjective Criterion Deviation , 2011, Int. J. Comput. Vis. Image Process..

[11]  Ram Bilas Pachori,et al.  Epileptic seizure classification in EEG signals using second-order difference plot of intrinsic mode functions , 2014, Comput. Methods Programs Biomed..

[12]  A.H. Khandoker,et al.  Wavelet-Based Feature Extraction for Support Vector Machines for Screening Balance Impairments in the Elderly , 2007, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[13]  Gabriel Rilling,et al.  Bivariate Empirical Mode Decomposition , 2007, IEEE Signal Processing Letters.

[14]  Danilo P. Mandic,et al.  Bivariate Empirical Mode Decomposition for Unbalanced Real-World Signals , 2013, IEEE Signal Processing Letters.

[15]  C. Elger,et al.  Spatio-temporal dynamics of the primary epileptogenic area in temporal lobe epilepsy characterized by neuronal complexity loss. , 1995, Electroencephalography and clinical neurophysiology.

[16]  H. Adeli,et al.  Analysis of EEG records in an epileptic patient using wavelet transform , 2003, Journal of Neuroscience Methods.

[17]  H. Lüders,et al.  Presurgical evaluation of epilepsy. , 2001, Brain : a journal of neurology.

[18]  U. Rajendra Acharya,et al.  An Integrated Index for the Identification of Focal Electroencephalogram Signals Using Discrete Wavelet Transform and Entropy Measures , 2015, Entropy.

[19]  U. Rajendra Acharya,et al.  Automated identification of normal and diabetes heart rate signals using nonlinear measures , 2013, Comput. Biol. Medicine.

[20]  Ram Bilas Pachori,et al.  Discrimination between Ictal and Seizure-Free EEG Signals Using Empirical Mode Decomposition , 2008, J. Electr. Comput. Eng..

[21]  N. Huang,et al.  The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis , 1998, Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[22]  M G Marciani,et al.  Lateralization of the epileptogenic focus by computerized EEG study and neuropsychological evaluation. , 1992, The International journal of neuroscience.

[23]  Ralph G Andrzejak,et al.  Nonrandomness, nonlinear dependence, and nonstationarity of electroencephalographic recordings from epilepsy patients. , 2012, Physical review. E, Statistical, nonlinear, and soft matter physics.

[24]  Dheeraj Sharma,et al.  Analysis of focal and non-focal EEG signals using bivariate empirical mode decomposition , 2016, 2016 IEEE Students' Conference on Electrical, Electronics and Computer Science (SCEECS).

[25]  C. A. Boneau,et al.  The effects of violations of assumptions underlying the test. , 1960, Psychological bulletin.

[26]  Anindya Bijoy Das,et al.  Discrimination and classification of focal and non-focal EEG signals using entropy-based features in the EMD-DWT domain , 2016, Biomed. Signal Process. Control..

[27]  Saeed Rahati Quchani,et al.  Evolutionary model selection in a wavelet-based support vector machine for automated seizure detection , 2011, Expert Syst. Appl..

[28]  Shufang Li,et al.  Feature extraction and recognition of ictal EEG using EMD and SVM , 2013, Comput. Biol. Medicine.

[29]  David J. Hewson,et al.  Univariate and Bivariate Empirical Mode Decomposition for Postural Stability Analysis , 2008, EURASIP J. Adv. Signal Process..

[30]  Jonathan M. Lilly,et al.  Wavelet ridge diagnosis of time-varying elliptical signals with application to an oceanic eddy , 2006 .

[31]  S. Manikandan,et al.  Measures of dispersion , 2011, Journal of pharmacology & pharmacotherapeutics.

[32]  Ahmad Taher Azar,et al.  Performance analysis of support vector machines classifiers in breast cancer mammography recognition , 2013, Neural Computing and Applications.

[33]  Ram Bilas Pachori,et al.  Automatic diagnosis of septal defects based on tunable-Q wavelet transform of cardiac sound signals , 2015, Expert Syst. Appl..

[34]  Johan A. K. Suykens,et al.  Least Squares Support Vector Machine Classifiers , 1999, Neural Processing Letters.

[35]  D. Looney,et al.  Time-Frequency Analysis of EEG Asymmetry Using Bivariate Empirical Mode Decomposition , 2011, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[36]  L. Bécu,et al.  Evidence for three-dimensional unstable flows in shear-banding wormlike micelles. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[37]  E. Carrette,et al.  Functional brain connectivity from EEG in epilepsy: Seizure prediction and epileptogenic focus localization , 2014, Progress in Neurobiology.

[38]  U. Rajendra Acharya,et al.  Tunable-Q Wavelet Transform Based Multivariate Sub-Band Fuzzy Entropy with Application to Focal EEG Signal Analysis , 2017, Entropy.

[39]  Rajeev Sharma,et al.  Empirical Mode Decomposition Based Classification of Focal and Non-focal Seizure EEG Signals , 2014, 2014 International Conference on Medical Biometrics.

[40]  Sofia C. Olhede,et al.  Bivariate Instantaneous Frequency and Bandwidth , 2009, IEEE Transactions on Signal Processing.

[41]  Pradip Sircar,et al.  A novel approach for automated detection of focal EEG signals using empirical wavelet transform , 2016, Neural Computing and Applications.

[42]  Yan Li,et al.  Epileptogenic focus detection in intracranial EEG based on delay permutation entropy , 2013 .

[43]  U. Rajendra Acharya,et al.  Application of Empirical Mode Decomposition (EMD) for Automated Detection of epilepsy using EEG signals , 2012, Int. J. Neural Syst..

[44]  Suzanne Kieffer,et al.  Feature extraction and selection for objective gait analysis and fall risk assessment by accelerometry , 2011, Biomedical engineering online.

[45]  Deba Prasad Dash,et al.  A nonlinear feature based epileptic seizure detection using least square support vector machine classifier , 2015, TENCON 2015 - 2015 IEEE Region 10 Conference.

[46]  I Kourakis,et al.  Nonlinear dust-acoustic solitary waves in strongly coupled dusty plasmas. , 2012, Physical review. E, Statistical, nonlinear, and soft matter physics.

[47]  J Gotman,et al.  Asymmetry in delta activity in patients with focal epilepsy. , 1990, Electroencephalography and clinical neurophysiology.

[48]  H. Adeli,et al.  A spatio-temporal wavelet-chaos methodology for EEG-based diagnosis of Alzheimer's disease , 2008, Neuroscience Letters.

[49]  Xinghua Liu,et al.  Diagnosis of Breast Tumours and Evaluation of Prognostic Risk by Using Machine Learning Approaches , 2007, ICIC.

[50]  Danilo P. Mandic,et al.  Empirical Mode Decomposition-Based Time-Frequency Analysis of Multivariate Signals: The Power of Adaptive Data Analysis , 2013, IEEE Signal Processing Magazine.

[51]  R. Goodman,et al.  Cortical abnormalities in epilepsy revealed by local EEG synchrony , 2007, NeuroImage.

[52]  Rami J Oweis,et al.  Seizure classification in EEG signals utilizing Hilbert-Huang transform , 2011, Biomedical engineering online.

[53]  Hojjat Adeli,et al.  Fractality and a Wavelet-Chaos-Neural Network Methodology for EEG-Based Diagnosis of Autistic Spectrum Disorder , 2010, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[54]  Rajeev Sharma,et al.  Classification of epileptic seizures in EEG signals based on phase space representation of intrinsic mode functions , 2015, Expert Syst. Appl..

[55]  K. Tsakalis,et al.  Information Flow and Application to Epileptogenic Focus Localization From Intracranial EEG , 2009, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[56]  B. Litt,et al.  High-frequency oscillations and seizure generation in neocortical epilepsy. , 2004, Brain : a journal of neurology.

[57]  Ram Bilas Pachori,et al.  Classification of seizure and seizure-free EEG signals using multi-level local patterns , 2014, 2014 19th International Conference on Digital Signal Processing.

[58]  Hans Hallez,et al.  Ictal‐onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy , 2013, Epilepsia.

[59]  Oren Sagher,et al.  Mapping and assessment of epileptogenic foci using frequency-entropy templates. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[60]  Abhishek Kumar,et al.  Machine learning approach for epileptic seizure detection using wavelet analysis of EEG signals , 2014, 2014 International Conference on Medical Imaging, m-Health and Emerging Communication Systems (MedCom).

[61]  Mark Newton,et al.  Changes in cortical excitability differentiate generalized and focal epilepsy , 2007, Annals of neurology.