Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition.

BACKGROUND Fatty acids in blood may be related to the risk of prostate cancer, but epidemiologic evidence is inconsistent. Blood fatty acids are correlated through shared food sources and common endogenous desaturation and elongation pathways. Studies of individual fatty acids cannot take this into account, but pattern analysis can. Treelet transform (TT) is a novel method that uses data correlation structures to derive sparse factors that explain variation. OBJECTIVE The objective was to gain further insight in the association between plasma fatty acids and risk of prostate cancer by applying TT to take data correlations into account. DESIGN We reanalyzed previously published data from a case-control study of prostate cancer nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. TT was used to derive factors explaining the variation in 26 plasma phospholipid fatty acids of 962 incident prostate cancer cases matched to 1061 controls. Multiple imputation was used to deal with missing data in covariates. ORs of prostate cancer according to factor scores were determined by using multivariable conditional logistic regression. RESULTS Four simple factors explained 38% of the variation in plasma fatty acids. A high score on a factor reflecting a long-chain n-3 PUFA pattern was associated with greater risk of prostate cancer (OR for highest compared with lowest quintile: 1.36; 95% CI: 0.99, 1.86; P-trend = 0.041). CONCLUSION Pattern analyses using TT groupings of correlated fatty acids indicate that intake or metabolism of long-chain n-3 PUFAs may be relevant to prostate cancer etiology.

[1]  Bruno Giraudeau,et al.  Diet, Cancer, and the Lipidome , 2006, Cancer Epidemiology Biomarkers & Prevention.

[2]  M. Stampfer,et al.  A Prospective Study of Polyunsaturated Fatty Acid Levels in Blood and Prostate Cancer Risk , 2007, Cancer Epidemiology Biomarkers & Prevention.

[3]  F. Grodstein,et al.  Prospective study of plasma fatty acids and risk of prostate cancer. , 1994, Journal of the National Cancer Institute.

[4]  Ann B. Lee,et al.  Treelets--An adaptive multi-scale basis for sparse unordered data , 2007, 0707.0481.

[5]  J. Michalek,et al.  Prostate cancer in US Air Force veterans of the Vietnam war , 2006, Journal of Exposure Science and Environmental Epidemiology.

[6]  M. Schulze,et al.  Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project , 2002, Public Health Nutrition.

[7]  J. Sundström,et al.  Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study. , 2008, The American journal of clinical nutrition.

[8]  A. Tjønneland,et al.  Adipose Tissue Fatty Acid Patterns and Changes in Anthropometry: A Cohort Study , 2011, PloS one.

[9]  Daniel Gervini,et al.  Criteria for Evaluating Dimension-Reducing Components for Multivariate Data , 2004 .

[10]  M. Roizen.  Fish consumption and prostate cancer risk: a review and meta-analysis , 2011 .

[11]  I. Thompson,et al.  Serum phospholipid fatty acids and prostate cancer risk: results from the prostate cancer prevention trial. , 2011, American journal of epidemiology.

[12]  S. Bingham,et al.  Biomarkers in nutritional epidemiology: applications, needs and new horizons , 2009, Human Genetics.

[13]  L. Niskanen,et al.  Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: A population‐based cohort study , 2004, International journal of cancer.

[14]  C. Couet,et al.  The lipidome as a composite biomarker of the modifiable part of the risk of breast cancer. , 2008, Prostaglandins, leukotrienes, and essential fatty acids.

[15]  C. Mathers,et al.  Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 , 2010, International journal of cancer.

[16]  W. Willett,et al.  A Prospective Study of Trans-Fatty Acid Levels in Blood and Risk of Prostate Cancer , 2008, Cancer Epidemiology Biomarkers & Prevention.

[17]  A. Dieffenbacher,et al.  Lexicon of lipid nutrition (IUPAC Technical Report) , 2001 .

[18]  E. Riboli,et al.  Fatty acid composition in serum phospholipids and risk of breast cancer: A prospective cohort study in northern sweden , 2007, Lipids.

[19]  Frank B. Hu,et al.  Dietary pattern analysis: a new direction in nutritional epidemiology , 2002, Current opinion in lipidology.

[20]  E. Riboli,et al.  The second expert report, Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective , 2007 .

[21]  A. Evans,et al.  Plasma free fatty acid patterns and their relationship with CVD risk in a male middle-aged population , 2010, European Journal of Clinical Nutrition.

[22]  B. Fielding,et al.  Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. , 2008, Progress in lipid research.

[23]  A. Wolk,et al.  Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. , 2001, The Journal of nutrition.

[24]  M. Stampfer,et al.  A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. , 2008, The American journal of clinical nutrition.

[25]  R. Jackson,et al.  Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case–control study , 1999, British Journal of Cancer.

[26]  L. Lind,et al.  Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. , 2006, The American journal of clinical nutrition.

[27]  M. Mori,et al.  Erythrocyte fatty acids and prostate cancer risk: a comparison of methods. , 2010, Prostaglandins, leukotrienes, and essential fatty acids.

[28]  L. Vatten,et al.  Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. , 1997, International journal of cancer.

[29]  J Beare Rogers,et al.  LEXICON OF LIPID NUTRITION , 2001 .

[30]  D. Albanes,et al.  Fatty acids and risk of prostate cancer in a nested case-control study in male smokers. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[31]  Anu W. Turunen,et al.  Dioxins, polychlorinated biphenyls, methyl mercury and omega-3 polyunsaturated fatty acids as biomarkers of fish consumption , 2010, European Journal of Clinical Nutrition.

[32]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[33]  Claus Dethlefsen,et al.  Exploring dietary patterns by using the treelet transform. , 2011, American journal of epidemiology.

[34]  L. Vatten,et al.  Prediagnostic level of fatty acids in serum phospholipids: Ω‐3 and Ω‐6 fatty acids and the risk of prostate cancer , 1997 .

[35]  Katherine L Tucker,et al.  Empirically derived eating patterns using factor or cluster analysis: a review. , 2004, Nutrition reviews.

[36]  J. Stanford,et al.  The association of fatty acids with prostate cancer risk , 2001, The Prostate.

[37]  B. Henderson,et al.  Circulating fatty acids and prostate cancer risk in a nested case–control study: the Multiethnic Cohort , 2009, Cancer Causes & Control.

[38]  M. K. Campbell,et al.  Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. , 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[39]  N E Day,et al.  European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection , 2002, Public Health Nutrition.

[40]  K. Chamie,et al.  Agent Orange exposure, Vietnam War veterans, and the risk of prostate cancer , 2008, Cancer.

[41]  E. Riboli,et al.  Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. , 2008, The American journal of clinical nutrition.