Quantitative Analysis of Single and Mix Food Antiseptics Basing on SERS Spectra with PLSR Method

Usage and dosage of food antiseptics are very concerned due to their decisive influence in food safety. Surface-enhanced Raman scattering (SERS) effect was employed in this research to realize trace potassium sorbate (PS) and sodium benzoate (SB) detection. HfO2 ultrathin film-coated Ag NR array was fabricated as SERS substrate. Protected by HfO2 film, the SERS substrate possesses good acid resistance, which enables it to be applicable in acidic environment where PS and SB work. Regression relationship between SERS spectra of 0.3~10 mg/L PS solution and their concentration was calibrated by partial least squares regression (PLSR) method, and the concentration prediction performance was quite satisfactory. Furthermore, mixture solution of PS and SB was also quantitatively analyzed by PLSR method. Spectrum data of characteristic peak sections corresponding to PS and SB was used to establish the regression models of these two solutes, respectively, and their concentrations were determined accurately despite their characteristic peak sections overlapping. It is possible that the unique modeling process of PLSR method prevented the overlapped Raman signal from reducing the model accuracy.

[1]  John R. Lombardi,et al.  Theory of Enhance I Light Scattering from Molecules Adsorbed at the Metal-Solution Interface , 1979 .

[2]  M. Lin,et al.  Detection of melamine in gluten, chicken feed, and processed foods using surface enhanced Raman spectroscopy and HPLC. , 2008, Journal of food science.

[3]  B. Chiang,et al.  ANTIMICROBIAL AND PHYSICOCHEMICAL PROPERTIES OF METHYLCELLULOSE AND CHITOSAN FILMS CONTAINING A PRESERVATIVE , 1996 .

[4]  Huiliang Wen,et al.  Antifungal activities of anthocyanins from purple sweet potato in the presence of food preservatives , 2016, Food Science and Biotechnology.

[5]  Yuko S Yamamoto,et al.  Why and how do the shapes of surface-enhanced Raman scattering spectra change? Recent progress from mechanistic studies , 2016 .

[6]  S. George.  Atomic layer deposition: an overview. , 2010, Chemical reviews.

[7]  Mikko Ritala,et al.  Atomic layer deposition chemistry: recent developments and future challenges. , 2003, Angewandte Chemie.

[8]  B. Lendl,et al.  Surface enhanced Raman spectroscopic direct determination of low molecular weight biothiols in umbilical cord whole blood. , 2016, The Analyst.

[9]  Abraham Nitzan,et al.  Electromagnetic theory of enhanced Raman scattering by molecules adsorbed on rough surfaces , 1980 .

[10]  Duncan Graham,et al.  Surface-enhanced Raman scattering , 1998 .

[11]  Anne-Laure Boulesteix,et al.  Partial least squares: a versatile tool for the analysis of high-dimensional genomic data , 2006, Briefings Bioinform..

[12]  P. Nielsen,et al.  Effect of weak acid preservatives on growth of bakery product spoilage fungi at different water activities and pH values. , 2004, International journal of food microbiology.

[13]  M. Tuchman,et al.  Alternative pathway therapy for urea cycle disorders: twenty years later. , 2001, The Journal of pediatrics.

[14]  Kyung-Min Lee,et al.  Determination and Prediction of Fumonisin Contamination in Maize by Surface–Enhanced Raman Spectroscopy (SERS) , 2016, Food and Bioprocess Technology.

[15]  Mengjing Hou,et al.  Pinhole-Containing, Subnanometer-Thick Al2O3 Shell-Coated Ag Nanorods as Practical Substrates for Quantitative Surface-Enhanced Raman Scattering , 2016 .

[16]  P. Mahadevan,et al.  An overview , 2007, Journal of Biosciences.

[17]  S. S. Arya,et al.  Chemistry of sorbates—a basic perspective∗ , 1994 .

[18]  G. Schatz,et al.  Electromagnetic fields around silver nanoparticles and dimers. , 2004, The Journal of chemical physics.

[19]  Nuo Duan,et al.  Vibrio parahaemolyticus detection aptasensor using surface-enhanced Raman scattering , 2016 .

[20]  F E Würgler,et al.  The genotoxicity status of sorbic acid, potassium sorbate and sodium sorbate. , 1992, Mutation research.

[21]  Weifeng Zhang,et al.  A highly efficient flexible dye-sensitized solar cell based on nickel sulfide/platinum/titanium counter electrode , 2015, Nanoscale Research Letters.

[22]  Qing Huang,et al.  Highly Sensitive and Selective Surface-Enhanced Raman Spectroscopy Label-free Detection of 3,3',4,4'-Tetrachlorobiphenyl Using DNA Aptamer-Modified Ag-Nanorod Arrays. , 2016, ACS applied materials & interfaces.

[23]  D. McCall,et al.  Fabrication of SERS substrate for the detection of rhodamine 6G, glyphosate, melamine and salicylic acid ☆ , 2016 .

[24]  Mengjing Hou,et al.  Nanogap effects on near- and far-field plasmonic behaviors of metallic nanoparticle dimers. , 2015, Physical chemistry chemical physics : PCCP.

[25]  M. Doyle,et al.  Fate of enterohemorrhagic Escherichia coli O157:H7 in apple cider with and without preservatives , 1993, Applied and environmental microbiology.

[26]  Peng Zhang,et al.  Stealth surface modification of surface-enhanced Raman scattering substrates for sensitive and accurate detection in protein solutions. , 2015, ACS nano.

[27]  D. Straus,et al.  Efficacy of Chlorine Dioxide as a Gas and in Solution in the Inactivation of Two Trichothecene Mycotoxins , 2005, International journal of toxicology.

[28]  Gang Xiang,et al.  Detection of total protein in milk using phosphomolybdic acid-mediated surface-enhanced Raman spectroscopy , 2016 .

[29]  Stelios Psarakis,et al.  Multivariate statistical process control charts: an overview , 2007, Qual. Reliab. Eng. Int..

[30]  Lingxin Chen,et al.  A SERS-based lateral flow assay biosensor for highly sensitive detection of HIV-1 DNA. , 2016, Biosensors & bioelectronics.

[31]  Mengjing Hou,et al.  Ag Nanorods Coated with Ultrathin TiO2 Shells as Stable and Recyclable SERS Substrates , 2015, Scientific Reports.

[32]  Xinghui Zhang,et al.  SERS Detection of Dopamine Using Label-Free Acridine Red as Molecular Probe in Reduced Graphene Oxide/Silver Nanotriangle Sol Substrate , 2015, Nanoscale Research Letters.

[33]  G. Tremblay,et al.  The biochemistry and toxicology of benzoic acid metabolism and its relationship to the elimination of waste nitrogen. , 1993, Pharmacology & therapeutics.

[34]  J. Zhan,et al.  Hydrophobic gold nanostructures via electrochemical deposition for sensitive SERS detection of persistent toxic substances , 2015 .