IL6 gene-wide haplotype is associated with susceptibility to acute lung injury.

[1]  D. Talmor,et al.  Cytokine release following recruitment maneuvers. , 2007, Chest.

[2]  R. Kacmarek,et al.  A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis* , 2007, Critical care medicine.

[3]  A. Reiner,et al.  IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study , 2007, Human Genetics.

[4]  J. Michálek,et al.  Interleukin-6 gene variants and the risk of sepsis development in children. , 2007, Human immunology.

[5]  A. Reiner,et al.  Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. , 2007, American journal of human genetics.

[6]  A. Victor,et al.  Genetic and environmental contributions to plasma C-reactive protein and interleukin-6 levels – a study in twins , 2006, Genes and Immunity.

[7]  C. Flores,et al.  Genomics of acute lung injury. , 2006, Seminars in respiratory and critical care medicine.

[8]  Sharon R Browning,et al.  Multilocus association mapping using variable-length Markov chains. , 2006, American journal of human genetics.

[9]  M. Hollegaard,et al.  Cytokine gene polymorphism in human disease: on-line databases, Supplement 3 , 2006, Genes and Immunity.

[10]  N. Maca-Meyer,et al.  A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population , 2006, Genes and Immunity.

[11]  S. Gabriel,et al.  Efficiency and power in genetic association studies , 2005, Nature Genetics.

[12]  Diane P. Martin,et al.  Incidence and outcomes of acute lung injury. , 2005, The New England journal of medicine.

[13]  S. Humphries,et al.  Novel IL-6 haplotypes and disease association , 2005, Genes and Immunity.

[14]  L. Ware Prognostic determinants of acute respiratory distress syndrome in adults: Impact on clinical trial design , 2005, Critical care medicine.

[15]  K. Walley,et al.  The association of interleukin 6 haplotype clades with mortality in critically ill adults. , 2005, Archives of internal medicine.

[16]  Joe G. N. Garcia,et al.  Functional genomic insights into acute lung injury: role of ventilators and mechanical stress. , 2005, Proceedings of the American Thoracic Society.

[17]  Nicole Soranzo,et al.  A single-nucleotide polymorphism tagging set for human drug metabolism and transport , 2005, Nature Genetics.

[18]  N. Maca-Meyer,et al.  A Tale of Aborigines, Conquerors and Slaves: Alu Insertion Polymorphisms and the Peopling of Canary Islands , 2004, Annals of human genetics.

[19]  A. Cabrera de León,et al.  Leptin and altitude in the cardiovascular diseases. , 2004, Obesity research.

[20]  P. Sham,et al.  The future of association studies: gene-based analysis and replication. , 2004, American journal of human genetics.

[21]  O. Wagner,et al.  The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans. , 2004, Clinical chemistry.

[22]  Nathaniel Rothman,et al.  Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. , 2004, Journal of the National Cancer Institute.

[23]  John Quackenbush,et al.  Orthologous gene-expression profiling in multi-species models: search for candidate genes , 2004, Genome Biology.

[24]  Peter Donnelly,et al.  A comparison of bayesian methods for haplotype reconstruction from population genotype data. , 2003, American journal of human genetics.

[25]  G. O’Keefe,et al.  Interleukin-6 Promoter Haplotypes and Interleukin-6 Cytokine Responses , 2003, Shock.

[26]  Nicholas W Wood,et al.  Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping. , 2003, American journal of human genetics.

[27]  M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive care medicine.

[28]  E. Lander,et al.  Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease , 2003, Nature Genetics.

[29]  H. Kautiainen,et al.  A Prospective Study of Inflammation Markers in Patients at Risk of Indirect Acute Lung Injury , 2002, Shock.

[30]  S. Humphries,et al.  Genetic polymorphisms associated with susceptibility and outcome in ARDS. , 2002, Chest.

[31]  S. Weiss,et al.  Association studies in asthma genetics. , 2001, American journal of respiratory and critical care medicine.

[32]  J. Pugin,et al.  Cytokine balance in the lungs of patients with acute respiratory distress syndrome. , 2001, American journal of respiratory and critical care medicine.

[33]  D. Prows,et al.  Quantitative trait analysis of nickel-induced acute lung injury in mice. , 2001, American journal of respiratory cell and molecular biology.

[34]  Arthur S Slutsky,et al.  Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. , 2000, JAMA.

[35]  F. Green,et al.  Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation* , 2000, The Journal of Biological Chemistry.

[36]  F. Pociot,et al.  Cytokine gene polymorphism in human disease: on-line databases , 1999, Genes and Immunity.

[37]  J H Lubin,et al.  Power and sample size calculations in case-control studies of gene-environment interactions: comments on different approaches. , 1999, American journal of epidemiology.

[38]  P. Vineis,et al.  Bias and confounding in molecular epidemiological studies: special considerations. , 1998, Carcinogenesis.

[39]  C. Sprung,et al.  Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. , 1998, Critical care medicine.

[40]  J S Yudkin,et al.  The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. , 1998, The Journal of clinical investigation.

[41]  M. Daly,et al.  Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice , 1997, Nature Genetics.

[42]  J. Pittet,et al.  Biological markers of acute lung injury: prognostic and pathogenetic significance. , 1997, American journal of respiratory and critical care medicine.

[43]  Bente Klarlund Pedersen,et al.  Hypoxemia increases serum interleukin-6 in humans , 1997, European Journal of Applied Physiology and Occupational Physiology.

[44]  F. Stentz,et al.  Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. , 1995, Chest.

[45]  M. Lamy,et al.  The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. , 1994, American journal of respiratory and critical care medicine.

[46]  J. Villar,et al.  Multiple system organ failure in acute respiratory failure , 1991 .