Transplantation of hESC-derived hepatocytes protects mice from liver injury

[1]  J. Qian,et al.  WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors. , 2016, The Journal of clinical investigation.

[2]  Dave T. Gerrard,et al.  Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes , 2015, Journal of hepatology.

[3]  P. Rosenfeld,et al.  Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies , 2015, The Lancet.

[4]  R. Brunelli,et al.  Transplantation of human fetal biliary tree stem/progenitor cells into two patients with advanced liver cirrhosis , 2014, BMC Gastroenterology.

[5]  Jui-Yu Hsieh,et al.  Liver X receptor α (LXRα/NR1H3) regulates differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α. , 2014, Journal of hepatology.

[6]  S. Thorgeirsson,et al.  Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model. , 2014, The Journal of clinical investigation.

[7]  M. T. Donato,et al.  Neonatal Livers: A Source for the Isolation of Good-Performing Hepatocytes for Cell Transplantation , 2014, Cell transplantation.

[8]  W. Stremmel,et al.  Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse , 2014, BMC Gastroenterology.

[9]  Sangeeta N. Bhatia,et al.  Cell and tissue engineering for liver disease , 2014, Science Translational Medicine.

[10]  L. Combettes,et al.  Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells , 2014, Hepatology.

[11]  E. Gamazon,et al.  Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver. , 2014, Human molecular genetics.

[12]  Lisheng Wang,et al.  Immunogenicity and Tumorigenicity of Pluripotent Stem Cells and their Derivatives: Genetic and Epigenetic Perspectives , 2013, Current stem cell research & therapy.

[13]  O. Mirochnitchenko,et al.  Preclinical Studies for Induced Pluripotent Stem Cell-based Therapeutics* , 2013, The Journal of Biological Chemistry.

[14]  D. Gerber,et al.  Concise review: Clinical programs of stem cell therapies for liver and pancreas , 2013, Stem cells.

[15]  L. Vallier,et al.  Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors , 2013, BMC Biology.

[16]  Takanori Takebe,et al.  Vascularized and functional human liver from an iPSC-derived organ bud transplant , 2013, Nature.

[17]  J. Bowsher,et al.  Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts † , 2013, Hepatology.

[18]  Ludovic Vallier,et al.  Production of hepatocyte-like cells from human pluripotent stem cells , 2013, Nature Protocols.

[19]  C. Ju Damage‐associated molecular patterns: Their impact on the liver and beyond during acetaminophen overdose , 2012, Hepatology.

[20]  M. Gómez-Lechón,et al.  Clinical Outcome of Hepatocyte Transplantation in Four Pediatric Patients with Inherited Metabolic Diseases , 2012, Cell transplantation.

[21]  H. Onoe,et al.  Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC‐Derived Neural Cells in a Primate Model of Parkinson's Disease , 2012, Stem cells.

[22]  Hung-Chih Kuo,et al.  Rapid generation of mature hepatocyte‐like cells from human induced pluripotent stem cells by an efficient three‐step protocol , 2012, Hepatology.

[23]  Daniel J. Hoeppner,et al.  Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. , 2012, Gastroenterology.

[24]  A. Dhawan,et al.  Current status of hepatocyte transplantation. , 2012, Transplantation.

[25]  M. Ott,et al.  Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London , 2012, Cell transplantation.

[26]  M. T. Donato,et al.  Evaluation of cytochrome P450 activities in human hepatocytes in vitro. , 2012, Methods in molecular biology.

[27]  H. Baharvand,et al.  Differentiation and Transplantation of Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells , 2013, Stem Cell Reviews and Reports.

[28]  J. Carroll,et al.  Pioneer transcription factors: establishing competence for gene expression. , 2011, Genes & development.

[29]  G. Prestwich,et al.  Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche. , 2011, Biomaterials.

[30]  Sung‐Gyu Lee,et al.  Hepatic differentiation from human embryonic stem cells using stromal cells. , 2011, The Journal of surgical research.

[31]  L. Marchionni,et al.  In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins , 2011, Science Translational Medicine.

[32]  N. Benvenisty,et al.  The tumorigenicity of human embryonic and induced pluripotent stem cells , 2011, Nature Reviews Cancer.

[33]  Ludovic Vallier,et al.  Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. , 2010, The Journal of clinical investigation.

[34]  F. Nevens,et al.  Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like Cells , 2010, PloS one.

[35]  H. Baharvand,et al.  Enhanced Functions of Human Embryonic Stem Cell-derived Hepatocyte-like Cells on Three-dimensional Nanofibrillar Surfaces , 2010, Stem Cell Reviews and Reports.

[36]  D. Cyranoski Strange lesions after stem-cell therapy , 2010, Nature.

[37]  R. Pedersen,et al.  Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development , 2010, Hepatology.

[38]  A. Dhawan,et al.  Human hepatocyte transplantation: current experience and future challenges , 2010, Nature Reviews Gastroenterology &Hepatology.

[39]  D. Valbuena,et al.  Derivation, characterization, differentiation, and registration of seven human embryonic stem cell lines (VAL-3, -4, -5, -6M, -7, -8, and -9) on human feeder , 2010, In Vitro Cellular & Developmental Biology - Animal.

[40]  J. Castell,et al.  Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies , 2010, Analytical and bioanalytical chemistry.

[41]  A. Dhawan,et al.  Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation , 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[42]  Stephen Dalton,et al.  Highly efficient generation of human hepatocyte–like cells from induced pluripotent stem cells , 2010, Hepatology.

[43]  V. Vanneaux,et al.  The role of HGF on invasive properties and repopulation potential of human fetal hepatic progenitor cells. , 2009, Experimental cell research.

[44]  T. Ochiya,et al.  Cell Injury , Repair , Aging and Apoptosis A Mouse Model of Inducible Liver Injury Caused by TetOn Regulated Urokinase for Studies of Hepatocyte Transplantation , 2009 .

[45]  A. Dhawan,et al.  Human hepatocyte transplantation: state of the art , 2009, Journal of internal medicine.

[46]  Q. Yuan,et al.  Gastrointestinal , Hepatobiliary and Pancreatic Pathology Repopulation Efficiencies of Adult Hepatocytes , Fetal Liver Progenitor Cells , and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice , 2010 .

[47]  F. Lemaigre Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies. , 2009, Gastroenterology.

[48]  Roger A. Pedersen,et al.  Early Cell Fate Decisions of Human Embryonic Stem Cells and Mouse Epiblast Stem Cells Are Controlled by the Same Signalling Pathways , 2009, PloS one.

[49]  William M. Lee,et al.  Thinking through acetaminophen hepatotoxicity and liver transplantation: Choosing worthy recipients , 2009, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[50]  Alejandro Soto-Gutiérrez,et al.  Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. , 2009, Gastroenterology.

[51]  Gideon Rechavi,et al.  Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient , 2009, PLoS medicine.

[52]  Agustín Lahoz,et al.  Functional Assessment of the Quality of Human Hepatocyte Preparations for Cell Transplantation , 2008, Cell transplantation.

[53]  Catherine Payne,et al.  Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling , 2008, Proceedings of the National Academy of Sciences.

[54]  Ronald N Hines,et al.  The ontogeny of drug metabolism enzymes and implications for adverse drug events. , 2008, Pharmacology & therapeutics.

[55]  Ying Meng,et al.  Differentiation and Enrichment of Hepatocyte‐Like Cells from Human Embryonic Stem Cells In Vitro and In Vivo , 2007, Stem cells.

[56]  L. Reid,et al.  Identification and Characterization of Vitamin A‐Storing Cells in Fetal Liver: Implications for Functional Importance of Hepatic Stellate Cells in Liver Development and Hematopoiesis , 2007, Stem cells.

[57]  Nancy Cheng,et al.  Human hepatic stem cells from fetal and postnatal donors , 2007 .

[58]  J. Itskovitz‐Eldor,et al.  Directed differentiation of human embryonic stem cells into functional hepatic cells , 2007, Hepatology.

[59]  E. Kroon,et al.  Efficient differentiation of human embryonic stem cells to definitive endoderm , 2005, Nature Biotechnology.

[60]  R. Frydman,et al.  Repopulation of athymic mouse liver by cryopreserved early human fetal hepatoblasts. , 2004, Human gene therapy.

[61]  Li Li,et al.  Human Embryonic Stem Cells Possess Immune‐Privileged Properties , 2004, Stem cells.

[62]  C. Selden,et al.  Cellular therapies for liver replacement. , 2004, Transplant immunology.

[63]  Naohiro Terada,et al.  Embryoid‐body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes , 2002, Hepatology.

[64]  H. Malhi,et al.  Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes. , 2002, Journal of cell science.

[65]  P. Hayes,et al.  Animal models of fulminant hepatic failure: A critical evaluation , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.