Acquisition of New Concepts by Two Amnesic Patients

Two Korsakoff amnesics (A.G. and G.S.) and two control subjects were taught six new concepts. Each concept was composed of three parts: the name of the concept, the context in which the concept originated and its definition. The learning procedure consisted of two phases: (1) learning the concept names and definitions by means of the vanishing-cues method; (2) practice on examples of the concepts through a classification task: examples were either set in the same context as that given in the original definition or in mixed contexts (same and new contexts). Subjects were then tested after 24 hours, a week and a month on their ability to identify new examples as belonging to one of the conceptual rules studied (transfer tests). Both patients showed substantial learning. Patient A.G. was slow and dependent of the first letter cues in the vanishing-cues learning phase but nevertheless, she acquired a large and flexible conceptual knowledge and this was especially true for concepts that were practised by means of mixed-context examples. Patient G.S. easily learned to associate the definitions with the concept names but her conceptual knowledge remained more limited. These results confirm the existence of a semantic learning ability in amnesic patients. They also suggest that under appropriate learning conditions, amnesics may eventually acquire a new flexible conceptual knowledge.

[1]  D. Schacter,et al.  When priming persists: Long-lasting implicit memory for a single episode in amnesic patients , 1987, Neuropsychologia.

[2]  E Tulving,et al.  Priming and human memory systems. , 1990, Science.

[3]  E. Warrington,et al.  Conditioning in amnesic patients , 1979, Neuropsychologia.

[4]  A. Baddeley,et al.  What can amnesic patients learn? , 1976, Neuropsychologia.

[5]  E Tulving,et al.  Learning and retention of computer-related vocabulary in memory-impaired patients: method of vanishing cues. , 1986, Journal of clinical and experimental neuropsychology.

[6]  Francis J. Di Vesta,et al.  The Effects of Encoding Variability, Processing Activity, and Rule-Examples Sequence on the Transfer of Conceptual Rules. , 1984 .

[7]  E. Tulving,et al.  Long-lasting perceptual priming and semantic learning in amnesia: a case experiment. , 1991, Journal of experimental psychology. Learning, memory, and cognition.

[8]  D. Schacter,et al.  Toward a Cognitive Neuropsychology of Complex Learning , 1988 .

[9]  M. Rapport,et al.  Immunologically induced behavioral and electrophysiological changes in the rat. , 1974, Neuropsychologia.

[10]  Neil Charness,et al.  Teaching an amnesic a complex cognitive skill , 1988, Brain and Cognition.

[11]  Jordan Grafman,et al.  Handbook of Neuropsychology , 1991 .

[12]  I. Daum,et al.  Classical conditioning in patients with severe memory problems. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[13]  Herman Buschke,et al.  Selective reminding for analysis of memory and learning , 1973 .

[14]  P. Lewinsohn,et al.  Effects of Left and Right Cerebral Lesions on the Naming Process , 1972, Perceptual and motor skills.

[15]  N. Cohen,et al.  The impaired learning of semantic knowledge following bilateral medial temporal-lobe resection , 1988, Brain and Cognition.

[16]  L. Squire Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. , 1992, Psychological review.

[17]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[18]  H. Buschke,et al.  Genuine memory deficits in dementia , 1987 .

[19]  Marcia K. Johnson,et al.  Amnesia and second language learning , 1988, Brain and Cognition.