Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway

[1]  Huan Yang,et al.  The Akt/PKB pathway: molecular target for cancer drug discovery , 2005, Oncogene.

[2]  C. Thompson,et al.  Akt-dependent transformation: there is more to growth than just surviving , 2005, Oncogene.

[3]  F. Gallyas,et al.  Pivotal Role of Akt Activation in Mitochondrial Protection and Cell Survival by Poly(ADP-ribose)polymerase-1 Inhibition in Oxidative Stress* , 2005, Journal of Biological Chemistry.

[4]  M. Tatsuta,et al.  Cross talk between apoptosis and invasion signaling in cancer cells through caspase-3 activation. , 2005, Cancer research.

[5]  P. Sehgal,et al.  Transcriptional signaling from membrane raft-associated glucocorticoid receptor. , 2005, Biochemical and biophysical research communications.

[6]  J. Gurd,et al.  Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain , 2005, Journal of neuroscience research.

[7]  T. MacRae,et al.  The Small Heat Shock Proteins and Their Role in Human Disease , 2022 .

[8]  H. Kampinga,et al.  HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun. , 2005, Experimental hematology.

[9]  C. D'Arrigo,et al.  Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. , 2005, Cancer research.

[10]  J. C. Wilkinson,et al.  The Small Heat Shock Protein αB-crystallin Is a Novel Inhibitor of TRAIL-induced Apoptosis That Suppresses the Activation of Caspase-3* , 2005, Journal of Biological Chemistry.

[11]  E. Solary,et al.  Small heat shock proteins HSP27 and alphaB-crystallin: cytoprotective and oncogenic functions. , 2005, Antioxidants & redox signaling.

[12]  A. Arrigo In search of the molecular mechanism by which small stress proteins counteract apoptosis during cellular differentiation , 2005, Journal of cellular biochemistry.

[13]  H. Knutsen,et al.  Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat. , 2005, Cancer research.

[14]  S. Segal,et al.  The integrity of cholesterol-enriched microdomains is essential for the constitutive high activity of protein kinase B in tumour cells. , 2004, Biochemical Society transactions.

[15]  R. Gandour-Edwards,et al.  Heat shock protein 27 is expressed in normal and malignant human melanocytes in vivo , 2004, Journal of cutaneous pathology.

[16]  T. MacRae,et al.  Oligomerization, Chaperone Activity, and Nuclear Localization of p26, a Small Heat Shock Protein from Artemia franciscana* , 2004, Journal of Biological Chemistry.

[17]  M. Gleave,et al.  Heat Shock Protein 27 Increases after Androgen Ablation and Plays a Cytoprotective Role in Hormone-Refractory Prostate Cancer , 2004, Cancer Research.

[18]  Andrew D. Hamilton,et al.  Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt , 2004, Cancer Research.

[19]  T. Okumura,et al.  Serine/Threonine Kinase AKT Is Frequently Activated in Human Bile Duct Cancer and Is Associated with Increased Radioresistance , 2004, Cancer Research.

[20]  B. Hemmings,et al.  Advances in protein kinase B signalling: AKTion on multiple fronts. , 2004, Trends in biochemical sciences.

[21]  Peter Csermely,et al.  Response to Associate Editor , 2016 .

[22]  F. Gallyas,et al.  Protective Effect of Amiodarone but Not N- Desethylamiodarone on Postischemic Hearts through the Inhibition of Mitochondrial Permeability Transition , 2003, Journal of Pharmacology and Experimental Therapeutics.

[23]  L. Neckers,et al.  Heat shock protein 90 , 2003, Current opinion in oncology.

[24]  P. Csermely,et al.  Hsp90 Inhibition Accelerates Cell Lysis , 2003, Journal of Biological Chemistry.

[25]  S. Kiryu-Seo,et al.  Expression of the Activating Transcription Factor 3 Prevents c-Jun N-Terminal Kinase-Induced Neuronal Death by Promoting Heat Shock Protein 27 Expression and Akt Activation , 2003, The Journal of Neuroscience.

[26]  Takashi Tsuruo,et al.  Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal , 2003, Cancer science.

[27]  V. Fried,et al.  Interactions of STAT3 with Caveolin-1 and Heat Shock Protein 90 in Plasma Membrane Raft and Cytosolic Complexes , 2002, The Journal of Biological Chemistry.

[28]  V. Cryns,et al.  The Small Heat Shock Protein αB-crystallin Negatively Regulates Apoptosis during Myogenic Differentiation by Inhibiting Caspase-3 Activation* , 2002, The Journal of Biological Chemistry.

[29]  A. Waheed,et al.  Hsp90 Interactions and Acylation Target the G Protein Gα12 but Not Gα13 to Lipid Rafts* , 2002, The Journal of Biological Chemistry.

[30]  B. Hemmings,et al.  Identification of a Plasma Membrane Raft-Associated PKB Ser473 Kinase Activity that Is Distinct from ILK and PDK1 , 2002, Current Biology.

[31]  D. Golenbock,et al.  Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. , 2002, Journal of cell science.

[32]  M. Saji,et al.  Overexpression and overactivation of Akt in thyroid carcinoma. , 2001, Cancer research.

[33]  P. Dennis,et al.  Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. , 2001, Cancer research.

[34]  F. Chen,et al.  The Small Heat Shock Protein αB-Crystallin Negatively Regulates Cytochrome c- and Caspase-8-dependent Activation of Caspase-3 by Inhibiting Its Autoproteolytic Maturation* , 2001, The Journal of Biological Chemistry.

[35]  R. Morimoto,et al.  Role of the heat shock response and molecular chaperones in oncogenesis and cell death. , 2000, Journal of the National Cancer Institute.

[36]  H. Saibil,et al.  Hsp26: a temperature‐regulated chaperone , 1999, The EMBO journal.

[37]  Peter R. Baker,et al.  Role of accurate mass measurement (+/- 10 ppm) in protein identification strategies employing MS or MS/MS and database searching. , 1999, Analytical chemistry.

[38]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[39]  A. Shevchenko,et al.  Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. , 1996, Analytical chemistry.

[40]  J. Buchner,et al.  Transient Interaction of Hsp90 with Early Unfolding Intermediates of Citrate Synthase , 1995, The Journal of Biological Chemistry.

[41]  P. Mehlen,et al.  Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts. , 1995, Journal of immunology.

[42]  T. Smith,et al.  J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. , 1991, Biochemistry.

[43]  N. Sims Rapid Isolation of Metabolically Active Mitochondria from Rat Brain and Subregions Using Percoll Density Gradient Centrifugation , 1990, Journal of neurochemistry.

[44]  P. Csermely,et al.  Molecular chaperones in the etiology and therapy of cancer , 2008, Pathology & Oncology Research.

[45]  H. Xiang,et al.  Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis. , 2004, Cell death and differentiation.

[46]  J. Leunissen,et al.  The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. , 2003, Cell stress & chaperones.

[47]  J. Leunissen,et al.  The human genome encodes 10 α-crystallin–related small heat shock proteins: HspB1–10 , 2003 .

[48]  Olivier Sauvageot,et al.  Small stress proteins: modulation of intracellular redox state and protection against oxidative stress. , 2002, Progress in molecular and subcellular biology.

[49]  Donna R. Maglott,et al.  RefSeq and LocusLink: NCBI gene-centered resources , 2001, Nucleic Acids Res..

[50]  J. Buchner,et al.  Analysis of chaperone function using citrate synthase as nonnative substrate protein. , 1998, Methods in enzymology.