A specific amyloid-β protein assembly in the brain impairs memory

[1]  K. Duff,et al.  Untangling memory deficits , 2005, Nature Medicine.

[2]  B. Hyman,et al.  Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function , 2005, Science.

[3]  J. D. McGaugh,et al.  Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice , 2005, Neuron.

[4]  H. Orr Neurodegenerative disease: Neuron protection agency , 2004, Nature.

[5]  Edward A. Stern,et al.  Cortical Synaptic Integration In Vivo Is Disrupted by Amyloid-β Plaques , 2004, The Journal of Neuroscience.

[6]  C. Almeida,et al.  Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain , 2004, The Journal of Neuroscience.

[7]  H. J. Hansen,et al.  Pain in patients with multiple sclerosis: a population-based study. , 2003, Archives of neurology.

[8]  Carl W. Cotman,et al.  Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis , 2003, Science.

[9]  R Brookmeyer,et al.  Visual memory predicts Alzheimer’s disease more than a decade before diagnosis , 2003, Neurology.

[10]  A. Delacourte,et al.  Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP‐CTFs), associated with tau pathology stages, in Alzheimer's disease , 2002, Journal of neurochemistry.

[11]  W. K. Cullen,et al.  Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.

[12]  M. Albert Memory decline: The boundary between aging and age‐related disease , 2002, Annals of neurology.

[13]  George A. Carlson,et al.  The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease , 2002, The Journal of Neuroscience.

[14]  K. Ashe Learning and memory in transgenic mice modeling Alzheimer's disease. , 2001, Learning & memory.

[15]  C. Finch,et al.  Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? , 2001, Trends in Neurosciences.

[16]  Mikio Shoji,et al.  Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease , 2001, The Journal of Neuroscience.

[17]  Guiquan Chen,et al.  A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease , 2000, Nature.

[18]  Ralph A. Nixon,et al.  Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease , 2000, Nature.

[19]  Mark S. Cohen,et al.  Patterns of brain activation in people at risk for Alzheimer's disease. , 2000, The New England journal of medicine.

[20]  J. Mazziotta,et al.  Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[21]  W. Benzing,et al.  Evidence for glial-mediated inflammation in aged APPSW transgenic mice , 1999, Neurobiology of Aging.

[22]  R. Nicoll,et al.  Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[23]  J. Morrison,et al.  Life and death of neurons in the aging brain. , 1997, Science.

[24]  J. Buxbaum,et al.  Characterization of New Polyclonal Antibodies Specific for 40 and 42 Amino Acid-Long Amyloid β Peptides: Their Use to Examine the Cell Biology of Presenilins and the Immunohistochemistry of Sporadic Alzheimer’s Disease and Cerebral Amyloid Angiopathy Cases , 1997, Molecular medicine.

[25]  B. Hyman,et al.  APPSW Transgenic Mice Develop Age‐related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1 , 1997, Journal of neuropathology and experimental neurology.

[26]  S. Younkin,et al.  Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.

[27]  D. Selkoe,et al.  Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments , 1992, Nature.

[28]  J. Warren,et al.  Denaturation of globular proteins. 3. A comparative study of the interaction of urea with several proteins. , 1971, Biochimica et biophysica acta.

[29]  J. Warren,et al.  Denaturation of globular proteins. I. The interaction of urea and thiourea with bovine plasma albumin. , 1968, The Journal of biological chemistry.

[30]  Received , 1868, Buffalo medical and surgical journal.

[31]  Lei Chang,et al.  Femtomole immunodetection of synthetic and endogenous amyloid-β oligomers and its application to Alzheimer’s disease drug candidate screening , 2007, Journal of Molecular Neuroscience.

[32]  D. Dickson,et al.  Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[33]  Denise C. Park,et al.  Handbook of the Psychology of Aging , 1979 .