The Brain That Plays Music and Is Changed by It

Playing a musical instrument demands extensive procedural and motor learning that results in plastic reorganization of the human brain. These plastic changes seem to include the rapid unmasking of existing connections and the establishment of new ones. Therefore, both functional and structural changes take place in the brain of instrumentalists as they learn to cope with the demands of their activity. Neuroimaging techniques allow documentation of these plastic changes in the human brain. These plastic changes are fundamental to the accomplishment of skillful playing, but they pose a risk for the development of motor control dysfunctions that may give rise to overuse syndromes and focal, task-specific dystonia.

[1]  J. Fuster Memory in the cerebral cortex , 1994 .

[2]  J. Valls-Solé,et al.  Brain Cortical Activation during Guitar-Induced Hand Dystonia Studied by Functional MRI , 2000, NeuroImage.

[3]  Leslie G. Ungerleider,et al.  The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Decety,et al.  Brain structures participating in mental simulation of motor behavior: a neuropsychological interpretation. , 1990, Acta psychologica.

[5]  Mark Hallett,et al.  Abnormal somatosensory homunculus in dystonia of the hand , 1998, Annals of neurology.

[6]  S. Aou,et al.  Increases in excitability of neurons of the motor cortex of cats after rapid acquisition of eye blink conditioning , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[7]  J Valls-Solé,et al.  Rapid modulation of human cortical motor outputs following ischaemic nerve block. , 1993, Brain : a journal of neurology.

[8]  N. Byl,et al.  The neural consequences of repetition: clinical implications of a learning hypothesis. , 1997, Journal of hand therapy : official journal of the American Society of Hand Therapists.

[9]  D. Brooks,et al.  Motor sequence learning: a study with positron emission tomography , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  S. Stone-Elander,et al.  Motor learning in man: a positron emission tomographic study. , 1990, Neuroreport.

[11]  J P Donoghue,et al.  Immediate and delayed changes of rat motor cortical output representation with new forelimb configurations. , 1992, Cerebral cortex.

[12]  Á. Pascual-Leone,et al.  Applications of transcranial magnetic stimulation in studies on motor learning. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[13]  J. Fuster Memory in the cerebral cortex : an empirical approach to neural networks in the human and nonhuman primate , 1996 .

[14]  Á. Pascual-Leone,et al.  Abnormalities of spatial and temporal sensory discrimination in writer's cramp , 2001, Movement disorders : official journal of the Movement Disorder Society.

[15]  A. Keller,et al.  Long-term potentiation in the motor cortex. , 1989, Science.

[16]  J. Mazziotta,et al.  Mapping motor representations with positron emission tomography , 1994, Nature.

[17]  M. Hallett Is dystonia a sensory disorder? , 1995, Annals of neurology.

[18]  W. Greenough Structural correlates of information storage in the mammalian brain: a review and hypothesis , 1984, Trends in Neurosciences.

[19]  Á. Pascual-Leone,et al.  Study and modulation of human cortical excitability with transcranial magnetic stimulation. , 1998, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[20]  D. Ingvar,et al.  Distribution of cerebral blood flow in the dominant hemisphere during motor ideation and motor performance , 1977, Annals of neurology.

[21]  A. Keller,et al.  Long-term potentiation of thalamic input to the motor cortex induced by coactivation of thalamocortical and corticocortical afferents. , 1991, Journal of neurophysiology.

[22]  C. Woody Understanding the cellular basis of memory and learning. , 1986, Annual review of psychology.

[23]  Leslie G. Ungerleider,et al.  Functional MRI evidence for adult motor cortex plasticity during motor skill learning , 1995, Nature.

[24]  B. Rockstroh,et al.  Alteration of digital representations in somatosensory cortex in focal hand dystonia , 1998, Neuroreport.

[25]  M. Schieber,et al.  How somatotopic is the motor cortex hand area? , 1993, Science.

[26]  H Wichman,et al.  “Inner” Darts: Effects of Mental Practice on Performance of Dart Throwing , 1978, Perceptual and motor skills.

[27]  Scott T. Grafton,et al.  Functional imaging of procedural motor learning: Relating cerebral blood flow with individual subject performance , 1994, Human brain mapping.

[28]  M. Hallett The neurophysiology of dystonia. , 1998, Archives of neurology.

[29]  F. Wilson Acquisition and Loss of Skilled Movement in Musicians , 1989, Seminars in neurology.

[30]  M A Stadler,et al.  Explicit and implicit learning and maps of cortical motor output. , 1994, Science.

[31]  A. Rothstein,et al.  Mental and Physical Practice and the Learning and Retention of Open and Closed Skills , 1979 .

[32]  Á. Pascual-Leone,et al.  Transcranial magnetic stimulation: studying the brain-behaviour relationship by induction of 'virtual lesions'. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[33]  Scott T. Grafton,et al.  Functional Mapping of Sequence Learning in Normal Humans , 1995, Journal of Cognitive Neuroscience.

[34]  KM Jacobs,et al.  Reshaping the cortical motor map by unmasking latent intracortical connections , 1991, Science.

[35]  M. Hallett,et al.  Focal transcranial magnetic stimulation and response bias in a forced-choice task. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[36]  L Henry,et al.  Human Skills (2nd ed.). , 1990 .

[37]  M. Schieber How might the motor cortex individuate movements? , 1990, Trends in Neurosciences.

[38]  Karl J. Friston,et al.  Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[39]  W M Jenkins,et al.  A primate genesis model of focal dystonia and repetitive strain injury , 1996, Neurology.

[40]  M. Hallett,et al.  Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. , 1995, Journal of neurophysiology.

[41]  P E Roland,et al.  Does mental activity change the oxidative metabolism of the brain? , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[42]  M. Mishkin,et al.  Massive cortical reorganization after sensory deafferentation in adult macaques. , 1991, Science.

[43]  M. Denis Visual imagery and the use of mental practice in the development of motor skills. , 1985, Canadian journal of applied sport sciences. Journal canadien des sciences appliquees au sport.